{
  "url": "https://dantelabs.com/traits/abnormal-circulating-igg-concentration",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-igg-concentration",
    "id": "HP:0410242",
    "name": "Abnormal circulating IgG concentration",
    "definition": "An abnormal deviation from normal levels of IgG immunoglobulin in blood.",
    "synonyms": [
      "Abnormal circulating IgG level",
      "Abnormal IgG level in blood"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-immunoglobulin-concentration",
        "name": "Abnormal circulating immunoglobulin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-immunoglobulin-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-circulating-igg-concentration",
        "name": "Decreased circulating IgG concentration",
        "genes": 105,
        "url": "https://dantelabs.com/traits/decreased-circulating-igg-concentration"
      },
      {
        "slug": "increased-circulating-igg-concentration",
        "name": "Increased circulating IgG concentration",
        "genes": 29,
        "url": "https://dantelabs.com/traits/increased-circulating-igg-concentration"
      }
    ],
    "genes": [
      {
        "slug": "alg12",
        "symbol": "ALG12",
        "hgnc": "HGNC:19358",
        "name": "ALG12 alpha-1,6-mannosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg12"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkg"
      }
    ]
  }
}