{
  "url": "https://dantelabs.com/traits/abnormal-alpha-granules",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-alpha-granules",
    "id": "HP:0012483",
    "name": "Abnormal alpha granules",
    "definition": "Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-platelet-granules",
        "name": "Abnormal platelet granules",
        "url": "https://dantelabs.com/traits/abnormal-platelet-granules"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-alpha-granule-content",
        "name": "Abnormal alpha granule content",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-alpha-granule-content"
      },
      {
        "slug": "abnormal-number-of-alpha-granules",
        "name": "Abnormal number of alpha granules",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-number-of-alpha-granules"
      }
    ],
    "genes": [
      {
        "slug": "vipas39",
        "symbol": "VIPAS39",
        "hgnc": "HGNC:20347",
        "name": "VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vipas39"
      },
      {
        "slug": "vps33b",
        "symbol": "VPS33B",
        "hgnc": "HGNC:12712",
        "name": "VPS33B late endosome and lysosome associated",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33b"
      }
    ]
  }
}