{
  "url": "https://dantelabs.com/fi/genes/zmynd8",
  "gene": {
    "slug": "zmynd8",
    "symbol": "ZMYND8",
    "name": "zinc finger MYND-type containing 8",
    "hgnc": "HGNC:9397",
    "summary": null,
    "location": "20q13.12",
    "locusType": "gene with protein product",
    "aliases": [
      "RACK7",
      "KIAA1125"
    ],
    "previousSymbols": [
      "PRKCBP1"
    ],
    "ensemblId": "ENSG00000101040",
    "entrezId": 23613,
    "omim": [
      "615713"
    ],
    "uniprot": [
      "Q9ULU4"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "20",
      "start": 47209214,
      "end": 47356699,
      "strand": "-",
      "ensemblTranscript": "ENST00000471951.7",
      "refseqTranscript": "NM_001281775.3",
      "ensemblProtein": "ENSP00000420095.2",
      "refseqProtein": "NP_001268704.1",
      "exons": [
        {
          "start": 47209214,
          "end": 47210897
        },
        {
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        },
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        {
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        },
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      ],
      "cds": {
        "start": 47210761,
        "end": 47356670
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "20",
      "start": 45837859,
      "end": 45985567,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 46782957,
      "end": 47782956,
      "genes": [
        {
          "symbol": "EYA2",
          "ensemblId": "ENSG00000064655",
          "biotype": "protein_coding",
          "start": 46894587,
          "end": 47188844,
          "strand": "+",
          "slug": "eya2"
        },
        {
          "symbol": "NCOA3",
          "ensemblId": "ENSG00000124151",
          "biotype": "protein_coding",
          "start": 47501849,
          "end": 47656877,
          "strand": "+",
          "slug": "ncoa3"
        },
        {
          "symbol": "SULF2",
          "ensemblId": "ENSG00000196562",
          "biotype": "protein_coding",
          "start": 47656197,
          "end": 47786842,
          "strand": "-",
          "slug": "sulf2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "syndromic-complex-neurodevelopmental-disorder",
        "name": "Oireyhtymä, jolle on ominaista neurokehityksen häiriö",
        "diseases": [
          {
            "mondoId": "MONDO:0800439",
            "name": "Oireyhtymä, jolle on ominaista neurokehityksen häiriö",
            "genes": 23,
            "inheritance": null,
            "description": "Sairausryhmä, jossa kehitysviivettä esiintyy yhdessä aivojen ulkopuolisten oireiden kanssa. Kukin sairaus johtuu yhden geenin muutoksesta. Osa tässä mainituista geeneistä, kuten ANKRD17, ASH1L ja MYT1L, aiheuttaa sairauden, kun yksi kopio muuttuu, yleensä de novo -muutoksena; AFG2A-välitteinen sairaus edellyttää muutoksia molemmissa kopioissa.",
            "management": "Kehitykseen, koulunkäyntiin ja terapiaan liittyvää tukea sekä tutkimuksia kohtauksien, kasvun, näön, kuulon ja muiden elinten oireiden varalta geenistä riippuen. Geneettinen neuvonta riippuu geenistä: de novo -dominanttien muutosten kohdalla suositellaan vanhempien testausta ja resessiivisten muotojen kohdalla kantajatestausta.",
            "evidence": {
              "gencc": [
                "ClinGen"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/syndromic-complex-neurodevelopmental-disorder"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [
      {
        "slug": "afg2a",
        "symbol": "AFG2A",
        "name": "AAA ATPase AFG2A",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/afg2a"
      },
      {
        "slug": "ankrd17",
        "symbol": "ANKRD17",
        "name": "ankyrin repeat domain 17",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/ankrd17"
      },
      {
        "slug": "ap1s2",
        "symbol": "AP1S2",
        "name": "adaptor related protein complex 1 subunit sigma 2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/ap1s2"
      },
      {
        "slug": "ash1l",
        "symbol": "ASH1L",
        "name": "ASH1 like histone lysine methyltransferase",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/ash1l"
      },
      {
        "slug": "brpf1",
        "symbol": "BRPF1",
        "name": "bromodomain and PHD finger containing 1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/brpf1"
      },
      {
        "slug": "myt1l",
        "symbol": "MYT1L",
        "name": "myelin transcription factor 1 like",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/myt1l"
      },
      {
        "slug": "nfib",
        "symbol": "NFIB",
        "name": "nuclear factor I B",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/nfib"
      },
      {
        "slug": "pan2",
        "symbol": "PAN2",
        "name": "poly(A) specific ribonuclease subunit PAN2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/pan2"
      },
      {
        "slug": "qrich1",
        "symbol": "QRICH1",
        "name": "glutamine rich 1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/qrich1"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "name": "RNA, U4 small nuclear 2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/rnu4-2"
      },
      {
        "slug": "setd5",
        "symbol": "SETD5",
        "name": "SET domain containing 5",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/setd5"
      },
      {
        "slug": "tbck",
        "symbol": "TBCK",
        "name": "TBC1 domain containing kinase",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/tbck"
      }
    ],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}