{
  "url": "https://dantelabs.com/fi/genes/vegfc",
  "gene": {
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    "name": "vascular endothelial growth factor C",
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    "location": "4q34.3",
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    "aliases": [
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    "previousSymbols": [],
    "ensemblId": "ENSG00000150630",
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    "uniprot": [
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      "release": "v1.5",
      "chrom": "4",
      "start": 176683538,
      "end": 176792922,
      "strand": "-",
      "ensemblTranscript": "ENST00000618562.2",
      "refseqTranscript": "NM_005429.5",
      "ensemblProtein": "ENSP00000480043.1",
      "refseqProtein": "NP_005420.1",
      "exons": [
        {
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
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      "end": 177713881,
      "strand": "-"
    },
    "neighbourhood": {
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      "start": 176238230,
      "end": 177238229,
      "genes": [
        {
          "symbol": "ASB5",
          "ensemblId": "ENSG00000164122",
          "biotype": "protein_coding",
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          "end": 176277571,
          "strand": "-",
          "slug": "asb5"
        },
        {
          "symbol": "SPCS3",
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          "biotype": "protein_coding",
          "start": 176319960,
          "end": 176333045,
          "strand": "+",
          "slug": "spcs3"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "primary-lymphoedema-lymphatic-malformations",
        "name": "Ensisijainen lymfedeema ja lymfaattiset malformaatiot",
        "diseases": [
          {
            "mondoId": "MONDO:0014393",
            "name": "Lymfaattinen malformaatio 4",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "VEGFC-geenin muutosten aiheuttama perinnöllinen lymfedeema.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
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            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/primary-lymphoedema-lymphatic-malformations"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "toenail-dysplasia",
        "name": "Abnormal toenail development",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/toenail-dysplasia"
      },
      {
        "slug": "cellulitis",
        "name": "Bacterial infection of skin",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cellulitis"
      },
      {
        "slug": "pedal-edema",
        "name": "Fluid accumulation in lower limbs",
        "systems": [
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          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pedal-edema"
      },
      {
        "slug": "hydrocele-testis",
        "name": "Hydrocele testis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hydrocele-testis"
      },
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      },
      {
        "slug": "prominent-superficial-veins",
        "name": "Prominent veins",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/prominent-superficial-veins"
      },
      {
        "slug": "lymphedema",
        "name": "Swelling caused by excess lymph fluid under skin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/lymphedema"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}