{
  "url": "https://dantelabs.com/fi/genes/tmprss15",
  "gene": {
    "slug": "tmprss15",
    "symbol": "TMPRSS15",
    "name": "transmembrane serine protease 15",
    "hgnc": "HGNC:9490",
    "summary": null,
    "location": "21q21.1",
    "locusType": "gene with protein product",
    "aliases": [
      "ENTK",
      "MGC133046"
    ],
    "previousSymbols": [
      "PRSS7"
    ],
    "ensemblId": "ENSG00000154646",
    "entrezId": 5651,
    "omim": [
      "606635"
    ],
    "uniprot": [
      "P98073"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "21",
      "start": 18269116,
      "end": 18403785,
      "strand": "-",
      "ensemblTranscript": "ENST00000284885.8",
      "refseqTranscript": "NM_002772.3",
      "ensemblProtein": "ENSP00000284885.3",
      "refseqProtein": "NP_002763.3",
      "exons": [
        {
          "start": 18269116,
          "end": 18270124
        },
        {
          "start": 18275197,
          "end": 18275336
        },
        {
          "start": 18278964,
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        },
        {
          "start": 18281040,
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        },
        {
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        {
          "start": 18294603,
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        },
        {
          "start": 18297734,
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        },
        {
          "start": 18312945,
          "end": 18313077
        },
        {
          "start": 18315146,
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        },
        {
          "start": 18326432,
          "end": 18326572
        },
        {
          "start": 18329169,
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        },
        {
          "start": 18332084,
          "end": 18332173
        },
        {
          "start": 18341413,
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        {
          "start": 18343506,
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        {
          "start": 18343955,
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        },
        {
          "start": 18352903,
          "end": 18353052
        },
        {
          "start": 18353723,
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        },
        {
          "start": 18359757,
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        {
          "start": 18365140,
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        },
        {
          "start": 18372193,
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        },
        {
          "start": 18379283,
          "end": 18379318
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        {
          "start": 18383627,
          "end": 18383778
        },
        {
          "start": 18397879,
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        },
        {
          "start": 18398199,
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        },
        {
          "start": 18403478,
          "end": 18403785
        }
      ],
      "cds": {
        "start": 18269969,
        "end": 18403622
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "21",
      "start": 19641433,
      "end": 19858197,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 17836451,
      "end": 18836450,
      "genes": [
        {
          "symbol": "CHODL",
          "ensemblId": "ENSG00000154645",
          "biotype": "protein_coding",
          "start": 17901263,
          "end": 18270231,
          "strand": "+",
          "slug": "chodl"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-diarrhoeas-and-enteropathies",
        "name": "Synnynnäinen ripuli ja enteropatiat",
        "diseases": [
          {
            "mondoId": "MONDO:0009173",
            "name": "Enteropeptidaasin puutteesta johtuva synnynnäinen enteropatia",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Suolen entsyymin enteropeptidaasin puute, jonka aiheuttavat TMPRSS15-variantit. Puute estää haimaentsyymien digestiivisten entsyymien aktivoitumisen.",
            "management": "Haimaentsyymikorvaushoito on tehokas.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/congenital-diarrhoeas-and-enteropathies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "hypoproteinemia",
        "name": "Decreased protein levels in blood",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hypoproteinemia"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "hypoproteinemic-edema",
        "name": "Hypoproteinemic edema",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hypoproteinemic-edema"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}