{
  "url": "https://dantelabs.com/fi/genes/prss1",
  "gene": {
    "slug": "prss1",
    "symbol": "PRSS1",
    "name": "serine protease 1",
    "hgnc": "HGNC:9475",
    "summary": null,
    "location": "7q34",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "TRY1"
    ],
    "ensemblId": "ENSG00000204983",
    "entrezId": 5644,
    "omim": [
      "276000"
    ],
    "uniprot": [
      "P07477"
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    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "7",
      "start": 142749472,
      "end": 142753072,
      "strand": "+",
      "ensemblTranscript": "ENST00000311737.12",
      "refseqTranscript": "NM_002769.5",
      "ensemblProtein": "ENSP00000308720.7",
      "refseqProtein": "NP_002760.1",
      "exons": [
        {
          "start": 142749472,
          "end": 142749524
        },
        {
          "start": 142750555,
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        {
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        {
          "start": 142752431,
          "end": 142752567
        },
        {
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          "end": 142753072
        }
      ],
      "cds": {
        "start": 142749485,
        "end": 142753020
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
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      "end": 142460923,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 142251272,
      "end": 143251271,
      "genes": [
        {
          "symbol": "PRSS58",
          "ensemblId": "ENSG00000258223",
          "biotype": "protein_coding",
          "start": 142252141,
          "end": 142258062,
          "strand": "-",
          "slug": "prss58"
        },
        {
          "symbol": "TRBV11-2",
          "ensemblId": "ENSG00000241657",
          "biotype": "protein_coding",
          "start": 142433895,
          "end": 142434394,
          "strand": "+",
          "slug": "trbv11-2"
        },
        {
          "symbol": "PRSS2",
          "ensemblId": "ENSG00000275896",
          "biotype": "protein_coding",
          "start": 142760398,
          "end": 142774564,
          "strand": "+",
          "slug": "prss2"
        },
        {
          "symbol": "EPHB6",
          "ensemblId": "ENSG00000106123",
          "biotype": "protein_coding",
          "start": 142854809,
          "end": 142872810,
          "strand": "+",
          "slug": "ephb6"
        },
        {
          "symbol": "TRPV6",
          "ensemblId": "ENSG00000165125",
          "biotype": "protein_coding",
          "start": 142871208,
          "end": 142885781,
          "strand": "-",
          "slug": "trpv6"
        },
        {
          "symbol": "TRPV5",
          "ensemblId": "ENSG00000127412",
          "biotype": "protein_coding",
          "start": 142904277,
          "end": 142933746,
          "strand": "-",
          "slug": "trpv5"
        },
        {
          "symbol": "SOFU1",
          "ensemblId": "ENSG00000165131",
          "biotype": "protein_coding",
          "start": 142939343,
          "end": 142949915,
          "strand": "+",
          "slug": "sofu1"
        },
        {
          "symbol": "KEL",
          "ensemblId": "ENSG00000197993",
          "biotype": "protein_coding",
          "start": 142941114,
          "end": 142962369,
          "strand": "-",
          "slug": "kel"
        },
        {
          "symbol": "OR9A2",
          "ensemblId": "ENSG00000179468",
          "biotype": "protein_coding",
          "start": 143026200,
          "end": 143027132,
          "strand": "-",
          "slug": "or9a2"
        },
        {
          "symbol": "OR6V1",
          "ensemblId": "ENSG00000225781",
          "biotype": "protein_coding",
          "start": 143052341,
          "end": 143053282,
          "strand": "+",
          "slug": "or6v1"
        },
        {
          "symbol": "PIP",
          "ensemblId": "ENSG00000159763",
          "biotype": "protein_coding",
          "start": 143132077,
          "end": 143139746,
          "strand": "+",
          "slug": "pip"
        },
        {
          "symbol": "TAS2R39",
          "ensemblId": "ENSG00000236398",
          "biotype": "protein_coding",
          "start": 143183419,
          "end": 143184435,
          "strand": "+",
          "slug": "tas2r39"
        },
        {
          "symbol": "TAS2R40",
          "ensemblId": "ENSG00000221937",
          "biotype": "protein_coding",
          "start": 143222037,
          "end": 143223079,
          "strand": "+",
          "slug": "tas2r40"
        },
        {
          "symbol": "GSTK1",
          "ensemblId": "ENSG00000197448",
          "biotype": "protein_coding",
          "start": 143244093,
          "end": 143272483,
          "strand": "+",
          "slug": "gstk1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "pancreatitis",
        "name": "Haimatulehdus",
        "diseases": [
          {
            "mondoId": "MONDO:0004982",
            "name": "Haimatulehdus",
            "genes": 5,
            "inheritance": null,
            "description": "Haiman tulehdus.",
            "management": "Kivunhoito; haimaentsyymikorvaushoito eksokriinisen vajaatoiminnan vuoksi; diabeteksen hoito; vuosittainen EUS/MRCP-seuranta haimasyövän varalta 40 ikävuodesta alkaen; koko haiman poisto ja saarekesolujen autosiirto (TPIAT) hoitoresistenteissä tapauksissa",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Illumina",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/pancreatitis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-thrombosis",
        "name": "Abnormal blood clot",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/abnormal-thrombosis"
      },
      {
        "slug": "abnormal-circulating-enzyme-concentration-or-activity",
        "name": "Abnormal circulating enzyme concentration or activity",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-enzyme-concentration-or-activity"
      },
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diabetes-mellitus"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "steatorrhea",
        "name": "Fat in feces",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/steatorrhea"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "pleural-effusion",
        "name": "Fluid around lungs",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/pleural-effusion"
      },
      {
        "slug": "exocrine-pancreatic-insufficiency",
        "name": "Inability to properly digest food due to lack of pancreatic digestive enzymes",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/exocrine-pancreatic-insufficiency"
      },
      {
        "slug": "jaundice",
        "name": "Jaundice",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/jaundice"
      },
      {
        "slug": "pancreatic-calcification",
        "name": "Pancreatic calcification",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pancreatic-calcification"
      },
      {
        "slug": "pancreatitis",
        "name": "Pancreatic inflammation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/pancreatitis"
      },
      {
        "slug": "pancreatic-pseudocyst",
        "name": "Pancreatic pseudocyst",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/pancreatic-pseudocyst"
      },
      {
        "slug": "recurrent-pancreatitis",
        "name": "Recurring pancreas inflammation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-pancreatitis"
      },
      {
        "slug": "splanchnic-vein-thrombosis",
        "name": "Splanchnic vein thrombosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/splanchnic-vein-thrombosis"
      }
    ],
    "related": [
      {
        "slug": "cpa1",
        "symbol": "CPA1",
        "name": "carboxypeptidase A1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cpa1"
      },
      {
        "slug": "ctrc",
        "symbol": "CTRC",
        "name": "chymotrypsin C",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/ctrc"
      },
      {
        "slug": "spink1",
        "symbol": "SPINK1",
        "name": "serine peptidase inhibitor Kazal type 1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/spink1"
      },
      {
        "slug": "trpv6",
        "symbol": "TRPV6",
        "name": "transient receptor potential cation channel subfamily V member 6",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/trpv6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}