{
  "url": "https://dantelabs.com/fi/genes/nthl1",
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        {
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        {
          "symbol": "ATP6V0C",
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        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000259784",
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        {
          "symbol": "AMDHD2",
          "ensemblId": "ENSG00000162066",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "CEMP1",
          "ensemblId": "ENSG00000205923",
          "biotype": "protein_coding",
          "start": 2530035,
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          "strand": "-",
          "slug": "cemp1"
        },
        {
          "symbol": "PDPK1",
          "ensemblId": "ENSG00000140992",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "pdpk1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "colorectal-cancer-polyposis",
        "name": "Paksusuolen ja peräsuolen syöpä sekä polypoosi",
        "diseases": [
          {
            "mondoId": "MONDO:0021057",
            "name": "Suvussa esiintyvä adenomatoottinen polypoosi (klassinen tai lievä muoto)",
            "genes": 6,
            "inheritance": "autosomal-dominant",
            "description": "Satoja tai tuhansia paksusuolen adenoomia, ja hoitamattomana paksusuolisyövän riski on lähes varma. Ryhmään kuuluvat APC-geeniin liittyvä FAP sekä MUTYH-, NTHL1- ja MSH3-geeneihin liittyvä polypoosi.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/colorectal-cancer-polyposis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "adenomatous-colonic-polyposis",
        "name": "Adenomatous colonic polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/adenomatous-colonic-polyposis"
      },
      {
        "slug": "basal-cell-carcinoma",
        "name": "Basal cell carcinoma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/basal-cell-carcinoma"
      },
      {
        "slug": "bladder-neoplasm",
        "name": "Bladder neoplasm",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bladder-neoplasm"
      },
      {
        "slug": "breast-carcinoma",
        "name": "Breast cancer",
        "systems": [
          "abnormality-of-the-breast",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/breast-carcinoma"
      },
      {
        "slug": "colon-cancer",
        "name": "Colon cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/colon-cancer"
      },
      {
        "slug": "duodenal-adenocarcinoma",
        "name": "Duodenal adenocarcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/duodenal-adenocarcinoma"
      },
      {
        "slug": "endometrial-carcinoma",
        "name": "Endometrial carcinoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/endometrial-carcinoma"
      },
      {
        "slug": "non-hodgkin-lymphoma",
        "name": "Non-Hodgkin lymphoma",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/non-hodgkin-lymphoma"
      },
      {
        "slug": "meningioma",
        "name": "Noncancerous growth of membranes covering brain",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/meningioma"
      },
      {
        "slug": "ovarian-cyst",
        "name": "Ovarian cyst",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ovarian-cyst"
      },
      {
        "slug": "pancreatic-adenocarcinoma",
        "name": "Pancreatic adenocarcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pancreatic-adenocarcinoma"
      },
      {
        "slug": "prostate-cancer",
        "name": "Prostate cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prostate-cancer"
      },
      {
        "slug": "neoplasm-of-the-rectum",
        "name": "Rectal tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-rectum"
      },
      {
        "slug": "seborrheic-keratosis",
        "name": "Senile wart",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seborrheic-keratosis"
      },
      {
        "slug": "neoplasm-of-the-skin",
        "name": "Skin cancer",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-skin"
      },
      {
        "slug": "squamous-cell-carcinoma",
        "name": "Squamous cell carcinoma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/squamous-cell-carcinoma"
      }
    ],
    "related": [
      {
        "slug": "apc",
        "symbol": "APC",
        "name": "APC regulator of Wnt signaling pathway",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/apc"
      },
      {
        "slug": "msh3",
        "symbol": "MSH3",
        "name": "mutS homolog 3",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/msh3"
      },
      {
        "slug": "mutyh",
        "symbol": "MUTYH",
        "name": "mutY DNA glycosylase",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/mutyh"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/pold1"
      },
      {
        "slug": "pole",
        "symbol": "POLE",
        "name": "DNA polymerase epsilon, catalytic subunit",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/pole"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}