{
  "url": "https://dantelabs.com/fi/genes/mark2",
  "gene": {
    "slug": "mark2",
    "symbol": "MARK2",
    "name": "microtubule affinity regulating kinase 2",
    "hgnc": "HGNC:3332",
    "summary": null,
    "location": "11q13.1",
    "locusType": "gene with protein product",
    "aliases": [
      "PAR-1",
      "Par1b",
      "PAR-1B"
    ],
    "previousSymbols": [
      "EMK1"
    ],
    "ensemblId": "ENSG00000072518",
    "entrezId": 2011,
    "omim": [
      "600526"
    ],
    "uniprot": [
      "Q7KZI7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 63839110,
      "end": 63911020,
      "strand": "+",
      "ensemblTranscript": "ENST00000402010.8",
      "refseqTranscript": "NM_001039469.3",
      "ensemblProtein": "ENSP00000385751.2",
      "refseqProtein": "NP_001034558.2",
      "exons": [
        {
          "start": 63839110,
          "end": 63839560
        },
        {
          "start": 63895159,
          "end": 63895338
        },
        {
          "start": 63895580,
          "end": 63895633
        },
        {
          "start": 63898232,
          "end": 63898280
        },
        {
          "start": 63898608,
          "end": 63898673
        },
        {
          "start": 63898763,
          "end": 63898833
        },
        {
          "start": 63899052,
          "end": 63899108
        },
        {
          "start": 63899874,
          "end": 63900110
        },
        {
          "start": 63900559,
          "end": 63900678
        },
        {
          "start": 63900780,
          "end": 63900879
        },
        {
          "start": 63900957,
          "end": 63901069
        },
        {
          "start": 63902198,
          "end": 63902330
        },
        {
          "start": 63902601,
          "end": 63902782
        },
        {
          "start": 63903061,
          "end": 63903158
        },
        {
          "start": 63903986,
          "end": 63904147
        },
        {
          "start": 63904786,
          "end": 63905043
        },
        {
          "start": 63906088,
          "end": 63906114
        },
        {
          "start": 63908260,
          "end": 63908304
        },
        {
          "start": 63908877,
          "end": 63911020
        }
      ],
      "cds": {
        "start": 63839507,
        "end": 63909237
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 63606400,
      "end": 63678491,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 63375065,
      "end": 64375064,
      "genes": [
        {
          "symbol": "SLC22A9",
          "ensemblId": "ENSG00000149742",
          "biotype": "protein_coding",
          "start": 63369217,
          "end": 63411798,
          "strand": "+",
          "slug": "slc22a9"
        },
        {
          "symbol": "PLAAT5",
          "ensemblId": "ENSG00000168004",
          "biotype": "protein_coding",
          "start": 63461404,
          "end": 63491228,
          "strand": "-",
          "slug": "plaat5"
        },
        {
          "symbol": "LGALS12",
          "ensemblId": "ENSG00000133317",
          "biotype": "protein_coding",
          "start": 63505966,
          "end": 63519767,
          "strand": "+",
          "slug": "lgals12"
        },
        {
          "symbol": "PLAAT4",
          "ensemblId": "ENSG00000133321",
          "biotype": "protein_coding",
          "start": 63529451,
          "end": 63549076,
          "strand": "+",
          "slug": "plaat4"
        },
        {
          "symbol": "PLAAT2",
          "ensemblId": "ENSG00000133328",
          "biotype": "protein_coding",
          "start": 63552770,
          "end": 63564157,
          "strand": "-",
          "slug": "plaat2"
        },
        {
          "symbol": "PLAAT3",
          "ensemblId": "ENSG00000176485",
          "biotype": "protein_coding",
          "start": 63569750,
          "end": 63616901,
          "strand": "-",
          "slug": "plaat3"
        },
        {
          "symbol": "ATL3",
          "ensemblId": "ENSG00000184743",
          "biotype": "protein_coding",
          "start": 63624087,
          "end": 63671921,
          "strand": "-",
          "slug": "atl3"
        },
        {
          "symbol": "RTN3",
          "ensemblId": "ENSG00000133318",
          "biotype": "protein_coding",
          "start": 63681444,
          "end": 63759909,
          "strand": "+",
          "slug": "rtn3"
        },
        {
          "symbol": "ZFTA",
          "ensemblId": "ENSG00000188070",
          "biotype": "protein_coding",
          "start": 63759892,
          "end": 63769752,
          "strand": "-",
          "slug": "zfta"
        },
        {
          "symbol": "SPINDOC",
          "ensemblId": "ENSG00000168005",
          "biotype": "protein_coding",
          "start": 63813405,
          "end": 63827718,
          "strand": "+",
          "slug": "spindoc"
        },
        {
          "symbol": "RCOR2",
          "ensemblId": "ENSG00000167771",
          "biotype": "protein_coding",
          "start": 63910992,
          "end": 63919787,
          "strand": "-",
          "slug": "rcor2"
        },
        {
          "symbol": "NAA40",
          "ensemblId": "ENSG00000110583",
          "biotype": "protein_coding",
          "start": 63938669,
          "end": 63957324,
          "strand": "+",
          "slug": "naa40"
        },
        {
          "symbol": "COX8A",
          "ensemblId": "ENSG00000176340",
          "biotype": "protein_coding",
          "start": 63974579,
          "end": 63976543,
          "strand": "+",
          "slug": "cox8a"
        },
        {
          "symbol": "OTUB1",
          "ensemblId": "ENSG00000167770",
          "biotype": "protein_coding",
          "start": 63985853,
          "end": 64001811,
          "strand": "+",
          "slug": "otub1"
        },
        {
          "symbol": "MACROD1",
          "ensemblId": "ENSG00000133315",
          "biotype": "protein_coding",
          "start": 63998553,
          "end": 64166501,
          "strand": "-",
          "slug": "macrod1"
        },
        {
          "symbol": "FLRT1",
          "ensemblId": "ENSG00000126500",
          "biotype": "protein_coding",
          "start": 64035757,
          "end": 64119403,
          "strand": "+",
          "slug": "flrt1"
        },
        {
          "symbol": "STIP1",
          "ensemblId": "ENSG00000168439",
          "biotype": "protein_coding",
          "start": 64185272,
          "end": 64204549,
          "strand": "+",
          "slug": "stip1"
        },
        {
          "symbol": "FERMT3",
          "ensemblId": "ENSG00000149781",
          "biotype": "protein_coding",
          "start": 64205926,
          "end": 64223896,
          "strand": "+",
          "slug": "fermt3"
        },
        {
          "symbol": "TRPT1",
          "ensemblId": "ENSG00000149743",
          "biotype": "protein_coding",
          "start": 64223799,
          "end": 64226823,
          "strand": "-",
          "slug": "trpt1"
        },
        {
          "symbol": "NUDT22",
          "ensemblId": "ENSG00000149761",
          "biotype": "protein_coding",
          "start": 64225941,
          "end": 64230686,
          "strand": "+",
          "slug": "nudt22"
        },
        {
          "symbol": "DNAJC4",
          "ensemblId": "ENSG00000110011",
          "biotype": "protein_coding",
          "start": 64230158,
          "end": 64234286,
          "strand": "+",
          "slug": "dnajc4"
        },
        {
          "symbol": "VEGFB",
          "ensemblId": "ENSG00000173511",
          "biotype": "protein_coding",
          "start": 64234406,
          "end": 64239264,
          "strand": "+",
          "slug": "vegfb"
        },
        {
          "symbol": "FKBP2",
          "ensemblId": "ENSG00000173486",
          "biotype": "protein_coding",
          "start": 64241003,
          "end": 64244583,
          "strand": "+",
          "slug": "fkbp2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000286264",
          "biotype": "protein_coding",
          "start": 64241095,
          "end": 64244583,
          "strand": "+"
        },
        {
          "symbol": "PPP1R14B",
          "ensemblId": "ENSG00000173457",
          "biotype": "protein_coding",
          "start": 64244478,
          "end": 64246956,
          "strand": "-",
          "slug": "ppp1r14b"
        },
        {
          "symbol": "PLCB3",
          "ensemblId": "ENSG00000149782",
          "biotype": "protein_coding",
          "start": 64251498,
          "end": 64269424,
          "strand": "+",
          "slug": "plcb3"
        },
        {
          "symbol": "BAD",
          "ensemblId": "ENSG00000002330",
          "biotype": "protein_coding",
          "start": 64269828,
          "end": 64291946,
          "strand": "-",
          "slug": "bad"
        },
        {
          "symbol": "GPR137",
          "ensemblId": "ENSG00000173264",
          "biotype": "protein_coding",
          "start": 64270062,
          "end": 64290690,
          "strand": "+",
          "slug": "gpr137"
        },
        {
          "symbol": "KCNK4",
          "ensemblId": "ENSG00000182450",
          "biotype": "protein_coding",
          "start": 64291302,
          "end": 64300031,
          "strand": "+",
          "slug": "kcnk4"
        },
        {
          "symbol": "CATSPERZ",
          "ensemblId": "ENSG00000219435",
          "biotype": "protein_coding",
          "start": 64300338,
          "end": 64304770,
          "strand": "+",
          "slug": "catsperz"
        },
        {
          "symbol": "ESRRA",
          "ensemblId": "ENSG00000173153",
          "biotype": "protein_coding",
          "start": 64305080,
          "end": 64317859,
          "strand": "+",
          "slug": "esrra"
        },
        {
          "symbol": "TRMT112",
          "ensemblId": "ENSG00000173113",
          "biotype": "protein_coding",
          "start": 64316460,
          "end": 64318086,
          "strand": "-",
          "slug": "trmt112"
        },
        {
          "symbol": "PRDX5",
          "ensemblId": "ENSG00000126432",
          "biotype": "protein_coding",
          "start": 64317977,
          "end": 64321827,
          "strand": "+",
          "slug": "prdx5"
        },
        {
          "symbol": "CCDC88B",
          "ensemblId": "ENSG00000168071",
          "biotype": "protein_coding",
          "start": 64340197,
          "end": 64357534,
          "strand": "+",
          "slug": "ccdc88b"
        },
        {
          "symbol": "RPS6KA4",
          "ensemblId": "ENSG00000162302",
          "biotype": "protein_coding",
          "start": 64359134,
          "end": 64372215,
          "strand": "+",
          "slug": "rps6ka4"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "hip-dysplasia",
        "name": "Abnormal formation of the hip",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hip-dysplasia"
      },
      {
        "slug": "abnormal-helix-morphology",
        "name": "Abnormal helix morphology",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-helix-morphology"
      },
      {
        "slug": "microphthalmia",
        "name": "Abnormally small eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/microphthalmia"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "age-inappropriate-oppositional-behavior",
        "name": "Age-inappropriate oppositional behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/age-inappropriate-oppositional-behavior"
      },
      {
        "slug": "aggressive-behavior",
        "name": "Aggressive behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/aggressive-behavior"
      },
      {
        "slug": "agitation",
        "name": "Agitation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/agitation"
      },
      {
        "slug": "anxiety",
        "name": "Anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anxiety"
      },
      {
        "slug": "astigmatism",
        "name": "Astigmatism",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/astigmatism"
      },
      {
        "slug": "attention-deficit-hyperactivity-disorder",
        "name": "Attention deficit",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/attention-deficit-hyperactivity-disorder"
      },
      {
        "slug": "autistic-behavior",
        "name": "Autism spectrum disorder",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/autistic-behavior"
      },
      {
        "slug": "esophageal-atresia",
        "name": "Birth defect in which part of esophagus did not develop",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/esophageal-atresia"
      },
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "brisk-reflexes",
        "name": "Brisk reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/brisk-reflexes"
      },
      {
        "slug": "broad-hallux",
        "name": "Broad big toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/broad-hallux"
      },
      {
        "slug": "broad-forehead",
        "name": "Broad forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/broad-forehead"
      },
      {
        "slug": "broad-philtrum",
        "name": "Broad philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/broad-philtrum"
      },
      {
        "slug": "bulbous-nose",
        "name": "Bulbous nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bulbous-nose"
      },
      {
        "slug": "chronic-constipation",
        "name": "Chronic constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/chronic-constipation"
      },
      {
        "slug": "myopia",
        "name": "Close sighted",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myopia"
      },
      {
        "slug": "cognitive-regression",
        "name": "Cognitive regression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cognitive-regression"
      },
      {
        "slug": "telecanthus",
        "name": "Corners of eye widely separated",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/telecanthus"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "deep-philtrum",
        "name": "Deep philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/deep-philtrum"
      },
      {
        "slug": "deeply-set-eye",
        "name": "Deeply set eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/deeply-set-eye"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "sleep-disturbance",
        "name": "Difficulty sleeping",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sleep-disturbance"
      },
      {
        "slug": "insomnia",
        "name": "Difficulty staying or falling asleep",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/insomnia"
      },
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      },
      {
        "slug": "downslanted-palpebral-fissures",
        "name": "Downward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/downslanted-palpebral-fissures"
      },
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "posteriorly-rotated-ears",
        "name": "Ears rotated toward back of head",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/posteriorly-rotated-ears"
      },
      {
        "slug": "eeg-abnormality",
        "name": "EEG abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/eeg-abnormality"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "episodic-vomiting",
        "name": "Episodic vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/episodic-vomiting"
      },
      {
        "slug": "hypertrichosis",
        "name": "Excessive hair growth",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypertrichosis"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "hypermetropia",
        "name": "Farsightedness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hypermetropia"
      },
      {
        "slug": "thick-vermilion-border",
        "name": "Full lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thick-vermilion-border"
      },
      {
        "slug": "glanular-hypospadias",
        "name": "Glanular hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/glanular-hypospadias"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "hypercalcemia",
        "name": "High blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypercalcemia"
      },
      {
        "slug": "high-forehead",
        "name": "High forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/high-forehead"
      },
      {
        "slug": "hooded-upper-eyelid",
        "name": "Hooded upper eyelid",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hooded-upper-eyelid"
      },
      {
        "slug": "kyphosis",
        "name": "Hunched back",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/kyphosis"
      },
      {
        "slug": "generalized-joint-hypermobility",
        "name": "Hypermobility of all joints",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/generalized-joint-hypermobility"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "macrotia",
        "name": "Large ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/macrotia"
      },
      {
        "slug": "long-eyelashes",
        "name": "Long eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/long-eyelashes"
      },
      {
        "slug": "long-philtrum",
        "name": "Long philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/long-philtrum"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "low-set-ears",
        "name": "Low-set ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/low-set-ears"
      },
      {
        "slug": "synophrys",
        "name": "Monobrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/synophrys"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "narrow-face",
        "name": "Narrow face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/narrow-face"
      },
      {
        "slug": "anteverted-nares",
        "name": "Nasal tip, upturned",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anteverted-nares"
      },
      {
        "slug": "overfolded-helix",
        "name": "Overfolded ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/overfolded-helix"
      },
      {
        "slug": "sleep-apnea",
        "name": "Pauses in breathing while sleeping",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sleep-apnea"
      },
      {
        "slug": "phimosis",
        "name": "Phimosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/phimosis"
      },
      {
        "slug": "protruding-ear",
        "name": "Prominent ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/protruding-ear"
      },
      {
        "slug": "prominent-forehead",
        "name": "Prominent forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prominent-forehead"
      },
      {
        "slug": "prominent-nasal-tip",
        "name": "Prominent nasal tip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prominent-nasal-tip"
      },
      {
        "slug": "prominent-nose",
        "name": "Prominent nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prominent-nose"
      },
      {
        "slug": "relative-macrocephaly",
        "name": "Relatively large head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/relative-macrocephaly"
      },
      {
        "slug": "motor-stereotypy",
        "name": "Repetitive movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/motor-stereotypy"
      },
      {
        "slug": "short-palpebral-fissure",
        "name": "Short opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/short-palpebral-fissure"
      },
      {
        "slug": "short-philtrum",
        "name": "Short philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-philtrum"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "slender-nose",
        "name": "Slender nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/slender-nose"
      },
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      },
      {
        "slug": "stellate-iris",
        "name": "Stellate iris",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/stellate-iris"
      },
      {
        "slug": "thickened-helices",
        "name": "Thickened helices",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thickened-helices"
      },
      {
        "slug": "thoracic-scoliosis",
        "name": "Thoracic scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thoracic-scoliosis"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "hemiparesis",
        "name": "Weakness of one side of body",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hemiparesis"
      },
      {
        "slug": "syndactyly",
        "name": "Webbed fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/syndactyly"
      },
      {
        "slug": "wide-nasal-bridge",
        "name": "Wide nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/wide-nasal-bridge"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}