{
  "url": "https://dantelabs.com/fi/genes/loxhd1",
  "gene": {
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    "symbol": "LOXHD1",
    "name": "lipoxygenase homology PLAT domains 1",
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      "cds": {
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "18",
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      "strand": "-"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "PSTPIP2",
          "ensemblId": "ENSG00000152229",
          "biotype": "protein_coding",
          "start": 45983536,
          "end": 46072367,
          "strand": "-",
          "slug": "pstpip2"
        },
        {
          "symbol": "ATP5F1A",
          "ensemblId": "ENSG00000152234",
          "biotype": "protein_coding",
          "start": 46080248,
          "end": 46104334,
          "strand": "-",
          "slug": "atp5f1a"
        },
        {
          "symbol": "HAUS1",
          "ensemblId": "ENSG00000152240",
          "biotype": "protein_coding",
          "start": 46104326,
          "end": 46129589,
          "strand": "+",
          "slug": "haus1"
        },
        {
          "symbol": "ARK2N",
          "ensemblId": "ENSG00000152242",
          "biotype": "protein_coding",
          "start": 46173497,
          "end": 46321788,
          "strand": "+",
          "slug": "ark2n"
        },
        {
          "symbol": "ARK2C",
          "ensemblId": "ENSG00000141622",
          "biotype": "protein_coding",
          "start": 46326809,
          "end": 46463140,
          "strand": "+",
          "slug": "ark2c"
        },
        {
          "symbol": "ST8SIA5",
          "ensemblId": "ENSG00000101638",
          "biotype": "protein_coding",
          "start": 46667821,
          "end": 46759257,
          "strand": "-",
          "slug": "st8sia5"
        },
        {
          "symbol": "PIAS2",
          "ensemblId": "ENSG00000078043",
          "biotype": "protein_coding",
          "start": 46803218,
          "end": 46920160,
          "strand": "-",
          "slug": "pias2"
        },
        {
          "symbol": "KATNAL2",
          "ensemblId": "ENSG00000167216",
          "biotype": "protein_coding",
          "start": 46917180,
          "end": 47103478,
          "strand": "+",
          "slug": "katnal2"
        },
        {
          "symbol": "ELOA2",
          "ensemblId": "ENSG00000206181",
          "biotype": "protein_coding",
          "start": 47032527,
          "end": 47035621,
          "strand": "-",
          "slug": "eloa2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Kuulonalenema ja kuurous",
        "diseases": [
          {
            "mondoId": "MONDO:0019497",
            "name": "Oireeton geneettinen kuulonalenema",
            "genes": 97,
            "inheritance": null,
            "description": "Perinnöllinen kuulonalenema ilman muita lääketieteellisiä oireita. Siihen kuuluvat yleiset resessiiviset muodot, joita aiheuttavat GJB2, OTOF, SLC26A4, STRC ja monet muut geenit, sekä dominantit, X-kromosomiin liittyvät ja mitokondriaaliset muodot.",
            "management": "Geneettisen syyn tunteminen voi ohjata kuulotukea ja sisäkorvaistutteen valintaa, auttaa arvioimaan osallistumismahdollisuutta geenihoitokokeisiin (esimerkiksi OTOF) ja tukea perheneuvontaa.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "Natera",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "bilateral-sensorineural-hearing-impairment",
        "name": "Bilateral sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bilateral-sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/actg1"
      },
      {
        "slug": "afg2b",
        "symbol": "AFG2B",
        "name": "AAA ATPase AFG2B",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/afg2b"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/aifm1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/atp2b2"
      },
      {
        "slug": "cabp2",
        "symbol": "CABP2",
        "name": "calcium binding protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cabp2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cd164"
      },
      {
        "slug": "cdc14a",
        "symbol": "CDC14A",
        "name": "cell division cycle 14A",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cdc14a"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "name": "cadherin related 23",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cdh23"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/ceacam16"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "name": "calcium and integrin binding family member 2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cib2"
      },
      {
        "slug": "cldn14",
        "symbol": "CLDN14",
        "name": "claudin 14",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cldn14"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}