{
  "url": "https://dantelabs.com/fi/genes/klf11",
  "gene": {
    "slug": "klf11",
    "symbol": "KLF11",
    "name": "KLF transcription factor 11",
    "hgnc": "HGNC:11811",
    "summary": null,
    "location": "2p25.1",
    "locusType": "gene with protein product",
    "aliases": [
      "Tieg3",
      "MODY7",
      "FKLF"
    ],
    "previousSymbols": [
      "TIEG2"
    ],
    "ensemblId": "ENSG00000172059",
    "entrezId": 8462,
    "omim": [
      "603301"
    ],
    "uniprot": [
      "O14901"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "2",
      "start": 10043550,
      "end": 10054836,
      "strand": "+",
      "ensemblTranscript": "ENST00000305883.6",
      "refseqTranscript": "NM_003597.5",
      "ensemblProtein": "ENSP00000307023.1",
      "refseqProtein": "NP_003588.1",
      "exons": [
        {
          "start": 10043550,
          "end": 10043758
        },
        {
          "start": 10046150,
          "end": 10046419
        },
        {
          "start": 10047650,
          "end": 10048595
        },
        {
          "start": 10052227,
          "end": 10054836
        }
      ],
      "cds": {
        "start": 10043717,
        "end": 10052507
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "2",
      "start": 10182976,
      "end": 10194963,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 9549193,
      "end": 10549192,
      "genes": [
        {
          "symbol": "ADAM17",
          "ensemblId": "ENSG00000151694",
          "biotype": "protein_coding",
          "start": 9488482,
          "end": 9556732,
          "strand": "-",
          "slug": "adam17"
        },
        {
          "symbol": "YWHAQ",
          "ensemblId": "ENSG00000134308",
          "biotype": "protein_coding",
          "start": 9583334,
          "end": 9639472,
          "strand": "-",
          "slug": "ywhaq"
        },
        {
          "symbol": "TAF1B",
          "ensemblId": "ENSG00000115750",
          "biotype": "protein_coding",
          "start": 9843340,
          "end": 9934994,
          "strand": "+",
          "slug": "taf1b"
        },
        {
          "symbol": "GRHL1",
          "ensemblId": "ENSG00000134317",
          "biotype": "protein_coding",
          "start": 9951678,
          "end": 10002355,
          "strand": "+",
          "slug": "grhl1"
        },
        {
          "symbol": "CYS1",
          "ensemblId": "ENSG00000205795",
          "biotype": "protein_coding",
          "start": 10056473,
          "end": 10080944,
          "strand": "-",
          "slug": "cys1"
        },
        {
          "symbol": "RRM2",
          "ensemblId": "ENSG00000171848",
          "biotype": "protein_coding",
          "start": 10120698,
          "end": 10213114,
          "strand": "+",
          "slug": "rrm2"
        },
        {
          "symbol": "HPCAL1",
          "ensemblId": "ENSG00000115756",
          "biotype": "protein_coding",
          "start": 10297410,
          "end": 10427835,
          "strand": "+",
          "slug": "hpcal1"
        },
        {
          "symbol": "ODC1",
          "ensemblId": "ENSG00000115758",
          "biotype": "protein_coding",
          "start": 10435417,
          "end": 10450116,
          "strand": "-",
          "slug": "odc1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "diseases": [
          {
            "mondoId": "MONDO:0005015",
            "name": "Diabetes mellitus",
            "genes": 31,
            "inheritance": null,
            "description": "Metabolinen sairaus, jolle on ominaista poikkeuksellisen korkea verensokeri. Sen taustalla on insuliinin tuotannon väheneminen tai insuliiniresistenssi ja herkistymisen heikentyminen.",
            "management": "Teplizumabi (Tzield) vaiheen 2 oireettoman tyypin 1 diabeteksen hoitoon (FDA:n hyväksymä vuonna 2022); insuliinikorvaushoito kliinisen tyypin 1 diabeteksen alkaessa; TrialNet-vasta-aineseulonta suuren riskin sukulaisille; suljetun kierron insuliininantojärjestelmät",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/diabetes-mellitus"
      },
      {
        "slug": "maturity-onset-diabetes-of-the-young",
        "name": "Nuorten aikuisiän diabetes (MODY)",
        "diseases": [
          {
            "mondoId": "MONDO:0018911",
            "name": "Nuorten aikuisiän diabetes (MODY)",
            "genes": 12,
            "inheritance": "autosomal-dominant",
            "description": "MODY (maturity-onset diabetes of the young) on harvinainen, suvussa esiintyvä diabetesmuoto, joka on kliinisesti ja geneettisesti heterogeeninen. Sille on ominaista nuori sairastumisikä (yleensä 10–45 vuotta), oman insuliinituotannon säilyminen, haimasolujen autoimmuniteetin puuttuminen, lihavuuden ja insuliiniresistenssin puuttuminen sekä joissakin alatyypeissä haimän ulkopuoliset oireet.",
            "management": "GCK-MODY: hoitoa ei yleensä tarvita; HNF1A/HNF4A-MODY: pieniannoksiset sulfonyyliureat; HNF1B-MODY: insuliini ja munuaisten seuranta; monigeeninen tyypin 2 diabetes: elintapamuutos, metformiini, GLP-1-agonistit tai SGLT2-estäjät sairauksien yhteisvaikutusten mukaan",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/maturity-onset-diabetes-of-the-young"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-circulating-c-peptide-concentration",
        "name": "Abnormal circulating C-peptide concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-c-peptide-concentration"
      },
      {
        "slug": "abnormal-circulating-insulin-concentration",
        "name": "Abnormal circulating insulin concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-insulin-concentration"
      },
      {
        "slug": "abnormal-oral-glucose-tolerance",
        "name": "Abnormal oral glucose tolerance",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-oral-glucose-tolerance"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "systems": [],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      },
      {
        "slug": "abnormality-of-the-kidney",
        "name": "Abnormality of the kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormality-of-the-kidney"
      },
      {
        "slug": "autoimmune-antibody-positivity",
        "name": "Autoimmune antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/autoimmune-antibody-positivity"
      },
      {
        "slug": "large-for-gestational-age",
        "name": "Birth weight > 90th percentile",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/large-for-gestational-age"
      },
      {
        "slug": "renal-cyst",
        "name": "Cystic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/renal-cyst"
      },
      {
        "slug": "acanthosis-nigricans",
        "name": "Darkened and thickened skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/acanthosis-nigricans"
      },
      {
        "slug": "diabetic-ketoacidosis",
        "name": "Diabetic ketoacidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/diabetic-ketoacidosis"
      },
      {
        "slug": "elevated-hemoglobin-a1c",
        "name": "Elevated hemoglobin A1c",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-hemoglobin-a1c"
      },
      {
        "slug": "glycosuria",
        "name": "Glucose in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/glycosuria"
      },
      {
        "slug": "glucose-intolerance",
        "name": "Glucose intolerance",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/glucose-intolerance"
      },
      {
        "slug": "hepatocellular-adenoma",
        "name": "Hepatocellular adenoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hepatocellular-adenoma"
      },
      {
        "slug": "hyperglycemia",
        "name": "High blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperglycemia"
      },
      {
        "slug": "hyperinsulinemic-hypoglycemia",
        "name": "Hyperinsulinemic hypoglycemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperinsulinemic-hypoglycemia"
      },
      {
        "slug": "hypoinsulinemia",
        "name": "Hypoinsulinemia",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoinsulinemia"
      },
      {
        "slug": "exocrine-pancreatic-insufficiency",
        "name": "Inability to properly digest food due to lack of pancreatic digestive enzymes",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/exocrine-pancreatic-insufficiency"
      },
      {
        "slug": "insulin-resistant-diabetes-mellitus",
        "name": "Insulin resistant diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/insulin-resistant-diabetes-mellitus"
      },
      {
        "slug": "nephropathy",
        "name": "Kidney damage",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nephropathy"
      },
      {
        "slug": "neonatal-hypoglycemia",
        "name": "Low blood sugar in newborn",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neonatal-hypoglycemia"
      },
      {
        "slug": "maturity-onset-diabetes-of-the-young",
        "name": "Maturity-onset diabetes of the young",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/maturity-onset-diabetes-of-the-young"
      },
      {
        "slug": "retinopathy",
        "name": "Noninflammatory retina disease",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinopathy"
      },
      {
        "slug": "type-ii-diabetes-mellitus",
        "name": "Noninsulin-dependent diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/type-ii-diabetes-mellitus"
      },
      {
        "slug": "obesity",
        "name": "Obesity",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/obesity"
      },
      {
        "slug": "overweight",
        "name": "Overweight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/overweight"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "transient-neonatal-diabetes-mellitus",
        "name": "Transient neonatal diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/transient-neonatal-diabetes-mellitus"
      },
      {
        "slug": "pancreatic-hypoplasia",
        "name": "Underdeveloped pancreas",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pancreatic-hypoplasia"
      }
    ],
    "related": [
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "name": "ATP binding cassette subfamily C member 8",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/abcc8"
      },
      {
        "slug": "appl1",
        "symbol": "APPL1",
        "name": "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/appl1"
      },
      {
        "slug": "cel",
        "symbol": "CEL",
        "name": "carboxyl ester lipase",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/cel"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "name": "glucokinase",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/gck"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "name": "HNF1 homeobox A",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/hnf1a"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "name": "HNF1 homeobox B",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/hnf1b"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "name": "hepatocyte nuclear factor 4 alpha",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/hnf4a"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "name": "insulin",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/ins"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/kcnj11"
      },
      {
        "slug": "neurod1",
        "symbol": "NEUROD1",
        "name": "neuronal differentiation 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/neurod1"
      },
      {
        "slug": "pdx1",
        "symbol": "PDX1",
        "name": "pancreatic and duodenal homeobox 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/pdx1"
      },
      {
        "slug": "akt2",
        "symbol": "AKT2",
        "name": "AKT serine/threonine kinase 2",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/akt2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}