{
  "url": "https://dantelabs.com/fi/genes/homer2",
  "gene": {
    "slug": "homer2",
    "symbol": "HOMER2",
    "name": "homer scaffold protein 2",
    "hgnc": "HGNC:17513",
    "summary": null,
    "location": "15q25.2",
    "locusType": "gene with protein product",
    "aliases": [
      "CPD",
      "Cupidin",
      "Vesl-2",
      "HOMER-2B",
      "HOMER-2",
      "HOMER-2A",
      "DFNA68"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000103942",
    "entrezId": 9455,
    "omim": [
      "604799"
    ],
    "uniprot": [
      "Q9NSB8"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 82848983,
      "end": 82952720,
      "strand": "-",
      "ensemblTranscript": "ENST00000450735.7",
      "refseqTranscript": "NM_004839.4",
      "ensemblProtein": "ENSP00000407634.2",
      "refseqProtein": "NP_004830.2",
      "exons": [
        {
          "start": 82848983,
          "end": 82849903
        },
        {
          "start": 82851151,
          "end": 82851231
        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
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        },
        {
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        },
        {
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        }
      ],
      "cds": {
        "start": 82849715,
        "end": 82952535
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 83509838,
      "end": 83654661,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 82400852,
      "end": 83400851,
      "genes": [
        {
          "symbol": "GOLGA6L9",
          "ensemblId": "ENSG00000197978",
          "biotype": "protein_coding",
          "start": 82429816,
          "end": 82439153,
          "strand": "+",
          "slug": "golga6l9"
        },
        {
          "symbol": "RPS17",
          "ensemblId": "ENSG00000182774",
          "biotype": "protein_coding",
          "start": 82536592,
          "end": 82540622,
          "strand": "-",
          "slug": "rps17"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000260836",
          "biotype": "protein_coding",
          "start": 82536788,
          "end": 82573194,
          "strand": "-"
        },
        {
          "symbol": "CPEB1",
          "ensemblId": "ENSG00000214575",
          "biotype": "protein_coding",
          "start": 82543201,
          "end": 82648861,
          "strand": "-",
          "slug": "cpeb1"
        },
        {
          "symbol": "AP3B2",
          "ensemblId": "ENSG00000103723",
          "biotype": "protein_coding",
          "start": 82659281,
          "end": 82710112,
          "strand": "-",
          "slug": "ap3b2"
        },
        {
          "symbol": "FSD2",
          "ensemblId": "ENSG00000186628",
          "biotype": "protein_coding",
          "start": 82755362,
          "end": 82806148,
          "strand": "-",
          "slug": "fsd2"
        },
        {
          "symbol": "WHAMM",
          "ensemblId": "ENSG00000156232",
          "biotype": "protein_coding",
          "start": 82809581,
          "end": 82836108,
          "strand": "+",
          "slug": "whamm"
        },
        {
          "symbol": "RAMAC",
          "ensemblId": "ENSG00000169612",
          "biotype": "protein_coding",
          "start": 82986199,
          "end": 82991057,
          "strand": "+",
          "slug": "ramac"
        },
        {
          "symbol": "C15orf40",
          "ensemblId": "ENSG00000169609",
          "biotype": "protein_coding",
          "start": 82988364,
          "end": 83011647,
          "strand": "-",
          "slug": "c15orf40"
        },
        {
          "symbol": "BTBD1",
          "ensemblId": "ENSG00000064726",
          "biotype": "protein_coding",
          "start": 83016423,
          "end": 83067412,
          "strand": "-",
          "slug": "btbd1"
        },
        {
          "symbol": "TM6SF1",
          "ensemblId": "ENSG00000136404",
          "biotype": "protein_coding",
          "start": 83107369,
          "end": 83161068,
          "strand": "+",
          "slug": "tm6sf1"
        },
        {
          "symbol": "HDGFL3",
          "ensemblId": "ENSG00000166503",
          "biotype": "protein_coding",
          "start": 83112738,
          "end": 83208424,
          "strand": "-",
          "slug": "hdgfl3"
        },
        {
          "symbol": "BNC1",
          "ensemblId": "ENSG00000169594",
          "biotype": "protein_coding",
          "start": 83255884,
          "end": 83284664,
          "strand": "-",
          "slug": "bnc1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Kuulonalenema ja kuurous",
        "diseases": [
          {
            "mondoId": "MONDO:0019587",
            "name": "Autosomaalisesti dominantti, ei-oireyhtymään kuuluva kuulonalenema",
            "genes": 39,
            "inheritance": "autosomal-dominant",
            "description": "Ei-oireyhtymään kuuluvan kuurouden autosomaalisesti dominantti muoto.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0019497",
            "name": "Oireeton geneettinen kuulonalenema",
            "genes": 97,
            "inheritance": null,
            "description": "Perinnöllinen kuulonalenema ilman muita lääketieteellisiä oireita. Siihen kuuluvat yleiset resessiiviset muodot, joita aiheuttavat GJB2, OTOF, SLC26A4, STRC ja monet muut geenit, sekä dominantit, X-kromosomiin liittyvät ja mitokondriaaliset muodot.",
            "management": "Geneettisen syyn tunteminen voi ohjata kuulotukea ja sisäkorvaistutteen valintaa, auttaa arvioimaan osallistumismahdollisuutta geenihoitokokeisiin (esimerkiksi OTOF) ja tukea perheneuvontaa.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/actg1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/atp2b2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/cd164"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/ceacam16"
      },
      {
        "slug": "coch",
        "symbol": "COCH",
        "name": "cochlin",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/coch"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "name": "collagen type XI alpha 1 chain",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/col11a1"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "name": "collagen type XI alpha 2 chain",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/col11a2"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "name": "diaphanous related formin 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/diaph1"
      },
      {
        "slug": "eya4",
        "symbol": "EYA4",
        "name": "EYA transcriptional coactivator and phosphatase 4",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/eya4"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "name": "gap junction protein beta 2",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "name": "gap junction protein beta 6",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/gjb6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}