{
  "url": "https://dantelabs.com/fi/genes/dnase1l3",
  "gene": {
    "slug": "dnase1l3",
    "symbol": "DNASE1L3",
    "name": "deoxyribonuclease 1L3",
    "hgnc": "HGNC:2959",
    "summary": null,
    "location": "3p14.3",
    "locusType": "gene with protein product",
    "aliases": [
      "DNAS1L3",
      "LSD",
      "D3"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000163687",
    "entrezId": 1776,
    "omim": [
      "602244"
    ],
    "uniprot": [
      "Q13609"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 58192257,
      "end": 58210972,
      "strand": "-",
      "ensemblTranscript": "ENST00000394549.7",
      "refseqTranscript": "NM_004944.4",
      "ensemblProtein": "ENSP00000378053.2",
      "refseqProtein": "NP_004935.1",
      "exons": [
        {
          "start": 58192257,
          "end": 58192803
        },
        {
          "start": 58193343,
          "end": 58193439
        },
        {
          "start": 58197821,
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        },
        {
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        },
        {
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          "end": 58204881
        },
        {
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        },
        {
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          "end": 58208306
        },
        {
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          "end": 58210972
        }
      ],
      "cds": {
        "start": 58192687,
        "end": 58210906
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 58177984,
      "end": 58200424,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 57701615,
      "end": 58701614,
      "genes": [
        {
          "symbol": "SLMAP",
          "ensemblId": "ENSG00000163681",
          "biotype": "protein_coding",
          "start": 57755450,
          "end": 57931461,
          "strand": "+",
          "slug": "slmap"
        },
        {
          "symbol": "FLNB",
          "ensemblId": "ENSG00000136068",
          "biotype": "protein_coding",
          "start": 58008398,
          "end": 58172251,
          "strand": "+",
          "slug": "flnb"
        },
        {
          "symbol": "ABHD6",
          "ensemblId": "ENSG00000163686",
          "biotype": "protein_coding",
          "start": 58237502,
          "end": 58296814,
          "strand": "+",
          "slug": "abhd6"
        },
        {
          "symbol": "RPP14",
          "ensemblId": "ENSG00000163684",
          "biotype": "protein_coding",
          "start": 58306239,
          "end": 58324695,
          "strand": "+",
          "slug": "rpp14"
        },
        {
          "symbol": "HTD2",
          "ensemblId": "ENSG00000255154",
          "biotype": "protein_coding",
          "start": 58306239,
          "end": 58324695,
          "strand": "+",
          "slug": "htd2"
        },
        {
          "symbol": "PXK",
          "ensemblId": "ENSG00000168297",
          "biotype": "protein_coding",
          "start": 58332579,
          "end": 58426867,
          "strand": "+",
          "slug": "pxk"
        },
        {
          "symbol": "PDHB",
          "ensemblId": "ENSG00000168291",
          "biotype": "protein_coding",
          "start": 58425143,
          "end": 58434012,
          "strand": "-",
          "slug": "pdhb"
        },
        {
          "symbol": "KCTD6",
          "ensemblId": "ENSG00000168301",
          "biotype": "protein_coding",
          "start": 58491078,
          "end": 58502584,
          "strand": "+",
          "slug": "kctd6"
        },
        {
          "symbol": "ACOX2",
          "ensemblId": "ENSG00000168306",
          "biotype": "protein_coding",
          "start": 58504544,
          "end": 58537400,
          "strand": "-",
          "slug": "acox2"
        },
        {
          "symbol": "FAM107A",
          "ensemblId": "ENSG00000168309",
          "biotype": "protein_coding",
          "start": 58564114,
          "end": 58627651,
          "strand": "-",
          "slug": "fam107a"
        },
        {
          "symbol": "FAM3D",
          "ensemblId": "ENSG00000198643",
          "biotype": "protein_coding",
          "start": 58633941,
          "end": 58666877,
          "strand": "-",
          "slug": "fam3d"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "autoimmune-disease",
        "name": "Autoimmuunisairaus",
        "diseases": [
          {
            "mondoId": "MONDO:0007179",
            "name": "Autoimmuunisairaus",
            "genes": 20,
            "inheritance": null,
            "description": "Sairaus, joka johtuu yhden tai useamman elimen toiminnan heikentymisestä tai kudosvauriosta. Se syntyy, kun yksilön humoraalinen tai solullinen immuunivaste kohdistuu hänen omiin kudosainesosiinsa. Sairaus voi olla systeeminen (esim. systeeminen lupus erythematosus) tai elinspesifinen (esim. tyreoidiitti).",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/autoimmune-disease"
      },
      {
        "slug": "systemic-lupus-erythematosus",
        "name": "Systeeminen lupus erythematosus",
        "diseases": [
          {
            "mondoId": "MONDO:0007915",
            "name": "Systeeminen lupus erythematosus",
            "genes": 6,
            "inheritance": null,
            "description": "Autoimmuunisairaus, joka vaikuttaa useisiin elimiin ja johon liittyy tyypillisesti verisuonimuutoksia ja autovasta-aineiden tuotantoa. Useimmilla potilailla on antinukleaarisia vasta-aineita (ANA). Anti-dsDNA- tai anti-Smith-vasta-aineiden esiintyminen on hyvin spesifistä.",
            "management": "Tavanomainen SLE: hydroksiklorokiini, mykofenolaatti, belimumabi, anifrolumabi; komplementtivajeeseen liittyvä lupus: tuoreen pakastetun plasman (FFP) korvaushoito; interferonopatia: anifrolumabi, JAK-estäjät; kaikille: auringonsuojaus, sydän- ja verisuoniriskin hallinta, raskauden suunnittelu",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/fi/conditions/systemic-lupus-erythematosus"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-heart-valve-morphology",
        "name": "Abnormal heart valve morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-heart-valve-morphology"
      },
      {
        "slug": "ascites",
        "name": "Accumulation of fluid in the abdomen",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ascites"
      },
      {
        "slug": "angioedema",
        "name": "Angioedema",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/angioedema"
      },
      {
        "slug": "anti-dsdna-antibody-positivity",
        "name": "Anti-dsDNA antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anti-dsdna-antibody-positivity"
      },
      {
        "slug": "antinuclear-antibody-positivity",
        "name": "Antinuclear antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/antinuclear-antibody-positivity"
      },
      {
        "slug": "arthritis",
        "name": "Arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arthritis"
      },
      {
        "slug": "ataxia",
        "name": "Ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ataxia"
      },
      {
        "slug": "autoimmunity",
        "name": "Autoimmunity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/autoimmunity"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "dyspnea",
        "name": "Breathing difficulty",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dyspnea"
      },
      {
        "slug": "lymphoma",
        "name": "Cancer of lymphatic system",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lymphoma"
      },
      {
        "slug": "cerebral-palsy",
        "name": "Cerebral palsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cerebral-palsy"
      },
      {
        "slug": "cough",
        "name": "Cough",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cough"
      },
      {
        "slug": "hemoptysis",
        "name": "Coughing up blood",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hemoptysis"
      },
      {
        "slug": "cranial-nerve-paralysis",
        "name": "Cranial nerve paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cranial-nerve-paralysis"
      },
      {
        "slug": "sensory-neuropathy",
        "name": "Damage to nerves that sense feeling",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sensory-neuropathy"
      },
      {
        "slug": "decreased-circulating-complement-c3-concentration",
        "name": "Decreased circulating complement C3 concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c3-concentration"
      },
      {
        "slug": "decreased-circulating-complement-c4-concentration",
        "name": "Decreased circulating complement C4 concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c4-concentration"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "diminished-deep-tendon-reflex",
        "name": "Diminished deep tendon reflex",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diminished-deep-tendon-reflex"
      },
      {
        "slug": "emphysema",
        "name": "Emphysema",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/emphysema"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "pericardial-effusion",
        "name": "Fluid around heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pericardial-effusion"
      },
      {
        "slug": "pleural-effusion",
        "name": "Fluid around lungs",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pleural-effusion"
      },
      {
        "slug": "glomerulopathy",
        "name": "Glomerulopathy",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/glomerulopathy"
      },
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/proteinuria"
      },
      {
        "slug": "immunologic-hypersensitivity",
        "name": "Immunologic hypersensitivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/immunologic-hypersensitivity"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "episcleritis",
        "name": "Inflammation of the thin layer on top of the white part of eye",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/episcleritis"
      },
      {
        "slug": "inflammatory-abnormality-of-the-eye",
        "name": "Inflammatory abnormality of the eye",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/inflammatory-abnormality-of-the-eye"
      },
      {
        "slug": "irregular-hyperpigmentation",
        "name": "Irregular hyperpigmentation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/irregular-hyperpigmentation"
      },
      {
        "slug": "pruritus",
        "name": "Itching",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pruritus"
      },
      {
        "slug": "joint-dislocation",
        "name": "Joint dislocation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/joint-dislocation"
      },
      {
        "slug": "lupus-nephritis",
        "name": "Lupus nephritis",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/lupus-nephritis"
      },
      {
        "slug": "meningitis",
        "name": "Meningitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/meningitis"
      },
      {
        "slug": "myalgia",
        "name": "Muscle ache",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myalgia"
      },
      {
        "slug": "nausea-and-vomiting",
        "name": "Nausea and vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nausea-and-vomiting"
      },
      {
        "slug": "airway-obstruction",
        "name": "Obstructive lung disease",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/airway-obstruction"
      },
      {
        "slug": "hemiplegia-hemiparesis",
        "name": "Paralysis or weakness of one side of body",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hemiplegia-hemiparesis"
      },
      {
        "slug": "perinuclear-antineutrophil-antibody-positivity",
        "name": "Perinuclear antineutrophil antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/perinuclear-antineutrophil-antibody-positivity"
      },
      {
        "slug": "peripheral-neuropathy",
        "name": "Peripheral neuropathy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peripheral-neuropathy"
      },
      {
        "slug": "conjunctivitis",
        "name": "Pink eye",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/conjunctivitis"
      },
      {
        "slug": "recurrent-bacterial-infections",
        "name": "Recurrent bacterial infections",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-bacterial-infections"
      },
      {
        "slug": "reduced-circulating-complement-concentration",
        "name": "Reduced circulating complement concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/reduced-circulating-complement-concentration"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "skin-rash",
        "name": "Skin rash",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/skin-rash"
      },
      {
        "slug": "small-vessel-vasculitis",
        "name": "Small vessel vasculitis",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/small-vessel-vasculitis"
      },
      {
        "slug": "restrictive-ventilatory-defect",
        "name": "Stiff lung or chest wall causing decreased lung volume",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/restrictive-ventilatory-defect"
      },
      {
        "slug": "lymphadenopathy",
        "name": "Swollen lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lymphadenopathy"
      },
      {
        "slug": "systemic-lupus-erythematosus",
        "name": "Systemic lupus erythematosus",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/systemic-lupus-erythematosus"
      },
      {
        "slug": "uveitis",
        "name": "Uveitis",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/uveitis"
      }
    ],
    "related": [
      {
        "slug": "c1qa",
        "symbol": "C1QA",
        "name": "complement C1q A chain",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/c1qa"
      },
      {
        "slug": "prkcd",
        "symbol": "PRKCD",
        "name": "protein kinase C delta",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/prkcd"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/sat1"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "name": "three prime repair exonuclease 1",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/trex1"
      },
      {
        "slug": "unc93b1",
        "symbol": "UNC93B1",
        "name": "unc-93B1 regulator of TLR signaling",
        "shared": 2,
        "url": "https://dantelabs.com/fi/genes/unc93b1"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "name": "autoimmune regulator",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/aire"
      },
      {
        "slug": "atp2c1",
        "symbol": "ATP2C1",
        "name": "ATPase secretory pathway Ca2+ transporting 1",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/atp2c1"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "name": "caspase 10",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/casp10"
      },
      {
        "slug": "casp8",
        "symbol": "CASP8",
        "name": "caspase 8",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/casp8"
      },
      {
        "slug": "cblb",
        "symbol": "CBLB",
        "name": "Cbl proto-oncogene B",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/cblb"
      },
      {
        "slug": "chrng",
        "symbol": "CHRNG",
        "name": "cholinergic receptor nicotinic gamma subunit",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/chrng"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "shared": 1,
        "url": "https://dantelabs.com/fi/genes/ctla4"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}