{
  "url": "https://dantelabs.com/traits/vertebral-wedging",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "vertebral-wedging",
    "id": "HP:0008422",
    "name": "Wedge-shaped vertebrae",
    "label": "Vertebral wedging",
    "definition": "An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other.",
    "synonyms": [
      "anterior wedging",
      "Wedged vertebrae"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-vertebral-body-morphology",
        "name": "Abnormal vertebral body morphology",
        "url": "https://dantelabs.com/traits/abnormal-vertebral-body-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "anterior-wedging-of-t11",
        "name": "Anterior wedging of T11",
        "genes": 2,
        "url": "https://dantelabs.com/traits/anterior-wedging-of-t11"
      },
      {
        "slug": "anterior-wedging-of-t12",
        "name": "Anterior wedging of T12",
        "genes": 2,
        "url": "https://dantelabs.com/traits/anterior-wedging-of-t12"
      },
      {
        "slug": "posterior-wedging-of-vertebral-bodies",
        "name": "Posterior wedging of vertebral bodies",
        "genes": 2,
        "url": "https://dantelabs.com/traits/posterior-wedging-of-vertebral-bodies"
      },
      {
        "slug": "anterior-wedging-of-l1",
        "name": "Anterior wedging of L1",
        "genes": 1,
        "url": "https://dantelabs.com/traits/anterior-wedging-of-l1"
      },
      {
        "slug": "anterior-wedging-of-l2",
        "name": "Anterior wedging of L2",
        "genes": 1,
        "url": "https://dantelabs.com/traits/anterior-wedging-of-l2"
      }
    ],
    "genes": [
      {
        "slug": "cant1",
        "symbol": "CANT1",
        "hgnc": "HGNC:19721",
        "name": "calcium activated nucleotidase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cant1"
      },
      {
        "slug": "fkbp10",
        "symbol": "FKBP10",
        "hgnc": "HGNC:18169",
        "name": "FKBP prolyl isomerase 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fkbp10"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "slc13a1",
        "symbol": "SLC13A1",
        "hgnc": "HGNC:10916",
        "name": "solute carrier family 13 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc13a1"
      },
      {
        "slug": "ccn6",
        "symbol": "CCN6",
        "hgnc": "HGNC:12771",
        "name": "cellular communication network factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccn6"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "cul7",
        "symbol": "CUL7",
        "hgnc": "HGNC:21024",
        "name": "cullin 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul7"
      },
      {
        "slug": "ift43",
        "symbol": "IFT43",
        "hgnc": "HGNC:29669",
        "name": "intraflagellar transport 43",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift43"
      },
      {
        "slug": "npr2",
        "symbol": "NPR2",
        "hgnc": "HGNC:7944",
        "name": "natriuretic peptide receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npr2"
      },
      {
        "slug": "ptch1",
        "symbol": "PTCH1",
        "hgnc": "HGNC:9585",
        "name": "patched 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ptch1"
      },
      {
        "slug": "ptch2",
        "symbol": "PTCH2",
        "hgnc": "HGNC:9586",
        "name": "patched 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptch2"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "hgnc": "HGNC:16466",
        "name": "SUFU negative regulator of hedgehog signaling",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sufu"
      },
      {
        "slug": "fn1",
        "symbol": "FN1",
        "hgnc": "HGNC:3778",
        "name": "fibronectin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fn1"
      },
      {
        "slug": "ifitm5",
        "symbol": "IFITM5",
        "hgnc": "HGNC:16644",
        "name": "interferon induced transmembrane protein 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifitm5"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv4"
      }
    ]
  }
}