{
  "url": "https://dantelabs.com/traits/underfolded-helix",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "underfolded-helix",
    "id": "HP:0008577",
    "name": "Underfolded helix",
    "definition": "Underdevelopment of the helix that either affects the entire helix, or is localized.",
    "synonyms": [
      "Poorly folded helices"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "abnormally-folded-helix",
        "name": "Abnormally folded helix",
        "url": "https://dantelabs.com/traits/abnormally-folded-helix"
      }
    ],
    "narrower": [
      {
        "slug": "underfolded-superior-helices",
        "name": "Underfolded superior helices",
        "genes": 2,
        "url": "https://dantelabs.com/traits/underfolded-superior-helices"
      }
    ],
    "genes": [
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "fn1",
        "symbol": "FN1",
        "hgnc": "HGNC:3778",
        "name": "fibronectin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fn1"
      },
      {
        "slug": "scnm1",
        "symbol": "SCNM1",
        "hgnc": "HGNC:23136",
        "name": "sodium channel modifier 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnm1"
      },
      {
        "slug": "tmem94",
        "symbol": "TMEM94",
        "hgnc": "HGNC:28983",
        "name": "transmembrane protein 94",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem94"
      }
    ]
  }
}