{
  "url": "https://dantelabs.com/traits/shock",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "shock",
    "id": "HP:0031273",
    "name": "Shock",
    "definition": "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiovascular-system-physiology",
        "name": "Abnormal cardiovascular system physiology",
        "url": "https://dantelabs.com/traits/abnormal-cardiovascular-system-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "cardiogenic-shock",
        "name": "Cardiogenic shock",
        "genes": 9,
        "url": "https://dantelabs.com/traits/cardiogenic-shock"
      },
      {
        "slug": "hypovolemic-shock",
        "name": "Hypovolemic shock",
        "genes": 5,
        "url": "https://dantelabs.com/traits/hypovolemic-shock"
      }
    ],
    "genes": [
      {
        "slug": "rfc4",
        "symbol": "RFC4",
        "hgnc": "HGNC:9972",
        "name": "replication factor C subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfc4"
      },
      {
        "slug": "spout1",
        "symbol": "SPOUT1",
        "hgnc": "HGNC:26933",
        "name": "SPOUT domain containing methyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spout1"
      },
      {
        "slug": "tnf",
        "symbol": "TNF",
        "hgnc": "HGNC:11892",
        "name": "tumor necrosis factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnf"
      },
      {
        "slug": "trdn",
        "symbol": "TRDN",
        "hgnc": "HGNC:12261",
        "name": "triadin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trdn"
      }
    ]
  }
}