{
  "url": "https://dantelabs.com/traits/polysplenia",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "polysplenia",
    "id": "HP:0001748",
    "name": "Multiple small spleens",
    "label": "Polysplenia",
    "definition": "Polysplenia is a congenital disease manifested by multiple small accessory spleens.",
    "synonyms": [
      "Accessory spleens",
      "Multiple accessory spleens"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "supernumerary-spleens",
        "name": "Extra spleen",
        "url": "https://dantelabs.com/traits/supernumerary-spleens"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dand5",
        "symbol": "DAND5",
        "hgnc": "HGNC:26780",
        "name": "DAN domain BMP antagonist family member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dand5"
      },
      {
        "slug": "fryl",
        "symbol": "FRYL",
        "hgnc": "HGNC:29127",
        "name": "FRY like transcription coactivator",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fryl"
      },
      {
        "slug": "rfwd3",
        "symbol": "RFWD3",
        "hgnc": "HGNC:25539",
        "name": "ring finger and WD repeat domain 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfwd3"
      },
      {
        "slug": "acvr2b",
        "symbol": "ACVR2B",
        "hgnc": "HGNC:174",
        "name": "activin A receptor type 2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr2b"
      },
      {
        "slug": "cfap45",
        "symbol": "CFAP45",
        "hgnc": "HGNC:17229",
        "name": "cilia and flagella associated protein 45",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap45"
      },
      {
        "slug": "cfc1",
        "symbol": "CFC1",
        "hgnc": "HGNC:18292",
        "name": "cryptic, EGF-CFC family member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfc1"
      },
      {
        "slug": "clxn",
        "symbol": "CLXN",
        "hgnc": "HGNC:25678",
        "name": "calaxin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clxn"
      },
      {
        "slug": "yars1",
        "symbol": "YARS1",
        "hgnc": "HGNC:12840",
        "name": "tyrosyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars1"
      },
      {
        "slug": "zic3",
        "symbol": "ZIC3",
        "hgnc": "HGNC:12874",
        "name": "Zic family zinc finger 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic3"
      },
      {
        "slug": "ccdc39",
        "symbol": "CCDC39",
        "hgnc": "HGNC:25244",
        "name": "coiled-coil domain 39 molecular ruler complex subunit",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ccdc39"
      },
      {
        "slug": "ciroz",
        "symbol": "CIROZ",
        "hgnc": "HGNC:26730",
        "name": "ciliated left-right organizer protein containing ZP-N domains",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciroz"
      },
      {
        "slug": "dnaaf4",
        "symbol": "DNAAF4",
        "hgnc": "HGNC:21493",
        "name": "dynein axonemal assembly factor 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnaaf4"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "gpc4",
        "symbol": "GPC4",
        "hgnc": "HGNC:4452",
        "name": "glypican 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc4"
      },
      {
        "slug": "megf8",
        "symbol": "MEGF8",
        "hgnc": "HGNC:3233",
        "name": "multiple EGF like domains 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf8"
      },
      {
        "slug": "rab23",
        "symbol": "RAB23",
        "hgnc": "HGNC:14263",
        "name": "RAB23, member RAS oncogene family",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rab23"
      },
      {
        "slug": "brwd1",
        "symbol": "BRWD1",
        "hgnc": "HGNC:12760",
        "name": "bromodomain and WD repeat domain containing 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brwd1"
      },
      {
        "slug": "ccdc40",
        "symbol": "CCDC40",
        "hgnc": "HGNC:26090",
        "name": "coiled-coil domain 40 molecular ruler complex subunit",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc40"
      },
      {
        "slug": "ccno",
        "symbol": "CCNO",
        "hgnc": "HGNC:18576",
        "name": "cyclin O",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccno"
      },
      {
        "slug": "cfap221",
        "symbol": "CFAP221",
        "hgnc": "HGNC:33720",
        "name": "cilia and flagella associated protein 221",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap221"
      },
      {
        "slug": "cfap298",
        "symbol": "CFAP298",
        "hgnc": "HGNC:1301",
        "name": "cilia and flagella associated protein 298",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap298"
      },
      {
        "slug": "cfap300",
        "symbol": "CFAP300",
        "hgnc": "HGNC:28188",
        "name": "cilia and flagella associated protein 300",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap300"
      },
      {
        "slug": "cfap74",
        "symbol": "CFAP74",
        "hgnc": "HGNC:29368",
        "name": "cilia and flagella associated protein 74",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap74"
      },
      {
        "slug": "daw1",
        "symbol": "DAW1",
        "hgnc": "HGNC:26383",
        "name": "dynein assembly factor with WD repeats 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daw1"
      },
      {
        "slug": "dnaaf1",
        "symbol": "DNAAF1",
        "hgnc": "HGNC:30539",
        "name": "dynein axonemal assembly factor 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf1"
      },
      {
        "slug": "dnaaf11",
        "symbol": "DNAAF11",
        "hgnc": "HGNC:16725",
        "name": "dynein axonemal assembly factor 11",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf11"
      },
      {
        "slug": "dnaaf19",
        "symbol": "DNAAF19",
        "hgnc": "HGNC:32700",
        "name": "dynein axonemal assembly factor 19",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf19"
      },
      {
        "slug": "dnaaf2",
        "symbol": "DNAAF2",
        "hgnc": "HGNC:20188",
        "name": "dynein axonemal assembly factor 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf2"
      },
      {
        "slug": "dnaaf3",
        "symbol": "DNAAF3",
        "hgnc": "HGNC:30492",
        "name": "dynein axonemal assembly factor 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf3"
      },
      {
        "slug": "dnaaf5",
        "symbol": "DNAAF5",
        "hgnc": "HGNC:26013",
        "name": "dynein axonemal assembly factor 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf5"
      },
      {
        "slug": "dnaaf6",
        "symbol": "DNAAF6",
        "hgnc": "HGNC:28570",
        "name": "dynein axonemal assembly factor 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf6"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "hgnc": "HGNC:2940",
        "name": "dynein axonemal heavy chain 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah1"
      },
      {
        "slug": "dnah11",
        "symbol": "DNAH11",
        "hgnc": "HGNC:2942",
        "name": "dynein axonemal heavy chain 11",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah11"
      },
      {
        "slug": "dnah5",
        "symbol": "DNAH5",
        "hgnc": "HGNC:2950",
        "name": "dynein axonemal heavy chain 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah5"
      },
      {
        "slug": "dnah7",
        "symbol": "DNAH7",
        "hgnc": "HGNC:18661",
        "name": "dynein axonemal heavy chain 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah7"
      },
      {
        "slug": "dnah9",
        "symbol": "DNAH9",
        "hgnc": "HGNC:2953",
        "name": "dynein axonemal heavy chain 9",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah9"
      },
      {
        "slug": "dnai1",
        "symbol": "DNAI1",
        "hgnc": "HGNC:2954",
        "name": "dynein axonemal intermediate chain 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai1"
      },
      {
        "slug": "dnai2",
        "symbol": "DNAI2",
        "hgnc": "HGNC:18744",
        "name": "dynein axonemal intermediate chain 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai2"
      },
      {
        "slug": "dnajb13",
        "symbol": "DNAJB13",
        "hgnc": "HGNC:30718",
        "name": "DnaJ heat shock protein family (Hsp40) member B13",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb13"
      },
      {
        "slug": "dnal1",
        "symbol": "DNAL1",
        "hgnc": "HGNC:23247",
        "name": "dynein axonemal light chain 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnal1"
      },
      {
        "slug": "drc1",
        "symbol": "DRC1",
        "hgnc": "HGNC:24245",
        "name": "dynein regulatory complex subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc1"
      },
      {
        "slug": "drc2",
        "symbol": "DRC2",
        "hgnc": "HGNC:29937",
        "name": "dynein regulatory complex subunit 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc2"
      },
      {
        "slug": "drc4",
        "symbol": "DRC4",
        "hgnc": "HGNC:4166",
        "name": "dynein regulatory complex subunit 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc4"
      },
      {
        "slug": "foxj1",
        "symbol": "FOXJ1",
        "hgnc": "HGNC:3816",
        "name": "forkhead box J1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxj1"
      },
      {
        "slug": "gas2l2",
        "symbol": "GAS2L2",
        "hgnc": "HGNC:24846",
        "name": "growth arrest specific 2 like 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gas2l2"
      },
      {
        "slug": "hydin",
        "symbol": "HYDIN",
        "hgnc": "HGNC:19368",
        "name": "HYDIN axonemal central pair apparatus protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hydin"
      },
      {
        "slug": "lrrc56",
        "symbol": "LRRC56",
        "hgnc": "HGNC:25430",
        "name": "leucine rich repeat containing 56",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc56"
      },
      {
        "slug": "mcidas",
        "symbol": "MCIDAS",
        "hgnc": "HGNC:40050",
        "name": "multiciliate differentiation and DNA synthesis associated cell cycle protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcidas"
      },
      {
        "slug": "nek10",
        "symbol": "NEK10",
        "hgnc": "HGNC:18592",
        "name": "NIMA related kinase 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek10"
      },
      {
        "slug": "nme5",
        "symbol": "NME5",
        "hgnc": "HGNC:7853",
        "name": "NME/NM23 family member 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nme5"
      },
      {
        "slug": "nme8",
        "symbol": "NME8",
        "hgnc": "HGNC:16473",
        "name": "NME/NM23 family member 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nme8"
      },
      {
        "slug": "odad1",
        "symbol": "ODAD1",
        "hgnc": "HGNC:26560",
        "name": "outer dynein arm docking complex subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad1"
      },
      {
        "slug": "odad2",
        "symbol": "ODAD2",
        "hgnc": "HGNC:25583",
        "name": "outer dynein arm docking complex subunit 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad2"
      },
      {
        "slug": "odad3",
        "symbol": "ODAD3",
        "hgnc": "HGNC:28303",
        "name": "outer dynein arm docking complex subunit 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad3"
      },
      {
        "slug": "odad4",
        "symbol": "ODAD4",
        "hgnc": "HGNC:25280",
        "name": "outer dynein arm docking complex subunit 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad4"
      },
      {
        "slug": "ofd1",
        "symbol": "OFD1",
        "hgnc": "HGNC:2567",
        "name": "OFD1 centriole and centriolar satellite protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ofd1"
      },
      {
        "slug": "rpgr",
        "symbol": "RPGR",
        "hgnc": "HGNC:10295",
        "name": "retinitis pigmentosa GTPase regulator",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgr"
      },
      {
        "slug": "rsph1",
        "symbol": "RSPH1",
        "hgnc": "HGNC:12371",
        "name": "radial spoke head component 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph1"
      },
      {
        "slug": "rsph3",
        "symbol": "RSPH3",
        "hgnc": "HGNC:21054",
        "name": "radial spoke head 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph3"
      },
      {
        "slug": "rsph4a",
        "symbol": "RSPH4A",
        "hgnc": "HGNC:21558",
        "name": "radial spoke head component 4A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph4a"
      },
      {
        "slug": "rsph9",
        "symbol": "RSPH9",
        "hgnc": "HGNC:21057",
        "name": "radial spoke head component 9",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph9"
      },
      {
        "slug": "spag1",
        "symbol": "SPAG1",
        "hgnc": "HGNC:11212",
        "name": "sperm associated antigen 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spag1"
      },
      {
        "slug": "spef2",
        "symbol": "SPEF2",
        "hgnc": "HGNC:26293",
        "name": "sperm flagellar and cilia associated 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spef2"
      },
      {
        "slug": "stk36",
        "symbol": "STK36",
        "hgnc": "HGNC:17209",
        "name": "serine/threonine kinase 36",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk36"
      },
      {
        "slug": "ttc12",
        "symbol": "TTC12",
        "hgnc": "HGNC:23700",
        "name": "tetratricopeptide repeat domain 12",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc12"
      },
      {
        "slug": "zmynd10",
        "symbol": "ZMYND10",
        "hgnc": "HGNC:19412",
        "name": "zinc finger MYND-type containing 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmynd10"
      },
      {
        "slug": "cdon",
        "symbol": "CDON",
        "hgnc": "HGNC:17104",
        "name": "cell adhesion associated, oncogene regulated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdon"
      },
      {
        "slug": "gdf1",
        "symbol": "GDF1",
        "hgnc": "HGNC:4214",
        "name": "growth differentiation factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf1"
      },
      {
        "slug": "mmp21",
        "symbol": "MMP21",
        "hgnc": "HGNC:14357",
        "name": "matrix metallopeptidase 21",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp21"
      },
      {
        "slug": "mycn",
        "symbol": "MYCN",
        "hgnc": "HGNC:7559",
        "name": "MYCN proto-oncogene, bHLH transcription factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mycn"
      },
      {
        "slug": "nphp3",
        "symbol": "NPHP3",
        "hgnc": "HGNC:7907",
        "name": "nephrocystin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphp3"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      }
    ]
  }
}