{
  "url": "https://dantelabs.com/traits/open-angle-glaucoma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "open-angle-glaucoma",
    "id": "HP:0012108",
    "name": "Open angle glaucoma",
    "definition": "A type of glaucoma defined by an open, normal appearing anterior chamber angle and raised intraocular pressure,",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "glaucoma",
        "name": "Glaucoma",
        "url": "https://dantelabs.com/traits/glaucoma"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "efemp1",
        "symbol": "EFEMP1",
        "hgnc": "HGNC:3218",
        "name": "EGF-like fibulin extracellular matrix protein 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/efemp1"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "cyp1b1",
        "symbol": "CYP1B1",
        "hgnc": "HGNC:2597",
        "name": "cytochrome P450 family 1 subfamily B member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp1b1"
      },
      {
        "slug": "myoc",
        "symbol": "MYOC",
        "hgnc": "HGNC:7610",
        "name": "myocilin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myoc"
      },
      {
        "slug": "lmx1b",
        "symbol": "LMX1B",
        "hgnc": "HGNC:6654",
        "name": "LIM homeobox transcription factor 1 beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmx1b"
      },
      {
        "slug": "fgf10",
        "symbol": "FGF10",
        "hgnc": "HGNC:3666",
        "name": "fibroblast growth factor 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf10"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "asb10",
        "symbol": "ASB10",
        "hgnc": "HGNC:17185",
        "name": "ankyrin repeat and SOCS box containing 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asb10"
      },
      {
        "slug": "ntf4",
        "symbol": "NTF4",
        "hgnc": "HGNC:8024",
        "name": "neurotrophin 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntf4"
      },
      {
        "slug": "optn",
        "symbol": "OPTN",
        "hgnc": "HGNC:17142",
        "name": "optineurin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/optn"
      },
      {
        "slug": "wdr36",
        "symbol": "WDR36",
        "hgnc": "HGNC:30696",
        "name": "WD repeat domain 36",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr36"
      }
    ]
  }
}