{
  "url": "https://dantelabs.com/traits/oligozoospermia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "oligozoospermia",
    "id": "HP:0000798",
    "name": "Low sperm count",
    "label": "Oligozoospermia",
    "definition": "Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen.",
    "synonyms": [
      "Oligospermia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      }
    ],
    "narrower": [
      {
        "slug": "cryptozoospermia",
        "name": "Cryptozoospermia",
        "genes": 6,
        "url": "https://dantelabs.com/traits/cryptozoospermia"
      },
      {
        "slug": "severe-oligozoospermia",
        "name": "Severe oligozoospermia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/severe-oligozoospermia"
      }
    ],
    "genes": [
      {
        "slug": "catsper1",
        "symbol": "CATSPER1",
        "hgnc": "HGNC:17116",
        "name": "cation channel sperm associated 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/catsper1"
      },
      {
        "slug": "catsper2",
        "symbol": "CATSPER2",
        "hgnc": "HGNC:18810",
        "name": "cation channel sperm associated 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/catsper2"
      },
      {
        "slug": "ccdc34",
        "symbol": "CCDC34",
        "hgnc": "HGNC:25079",
        "name": "coiled-coil domain containing 34",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc34"
      },
      {
        "slug": "cep19",
        "symbol": "CEP19",
        "hgnc": "HGNC:28209",
        "name": "centrosomal protein 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep19"
      },
      {
        "slug": "cfap47",
        "symbol": "CFAP47",
        "hgnc": "HGNC:26708",
        "name": "cilia and flagella associated protein 47",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap47"
      },
      {
        "slug": "cfap54",
        "symbol": "CFAP54",
        "hgnc": "HGNC:26456",
        "name": "cilia and flagella associated protein 54",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap54"
      },
      {
        "slug": "cfap65",
        "symbol": "CFAP65",
        "hgnc": "HGNC:25325",
        "name": "cilia and flagella associated protein 65",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap65"
      },
      {
        "slug": "cfap70",
        "symbol": "CFAP70",
        "hgnc": "HGNC:30726",
        "name": "cilia and flagella associated protein 70",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap70"
      },
      {
        "slug": "cylc1",
        "symbol": "CYLC1",
        "hgnc": "HGNC:2582",
        "name": "cylicin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cylc1"
      },
      {
        "slug": "drc1",
        "symbol": "DRC1",
        "hgnc": "HGNC:24245",
        "name": "dynein regulatory complex subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc1"
      },
      {
        "slug": "dzip1",
        "symbol": "DZIP1",
        "hgnc": "HGNC:20908",
        "name": "DAZ interacting zinc finger protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dzip1"
      },
      {
        "slug": "fbxo43",
        "symbol": "FBXO43",
        "hgnc": "HGNC:28521",
        "name": "F-box protein 43",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo43"
      },
      {
        "slug": "kcnu1",
        "symbol": "KCNU1",
        "hgnc": "HGNC:18867",
        "name": "potassium calcium-activated channel subfamily U member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnu1"
      },
      {
        "slug": "klhl10",
        "symbol": "KLHL10",
        "hgnc": "HGNC:18829",
        "name": "kelch like family member 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl10"
      },
      {
        "slug": "m1ap",
        "symbol": "M1AP",
        "hgnc": "HGNC:25183",
        "name": "meiosis 1 associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/m1ap"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "rpl10l",
        "symbol": "RPL10L",
        "hgnc": "HGNC:17976",
        "name": "ribosomal protein L10 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl10l"
      },
      {
        "slug": "strc",
        "symbol": "STRC",
        "hgnc": "HGNC:16035",
        "name": "stereocilin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/strc"
      },
      {
        "slug": "sycp2",
        "symbol": "SYCP2",
        "hgnc": "HGNC:11490",
        "name": "synaptonemal complex protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sycp2"
      },
      {
        "slug": "tekt3",
        "symbol": "TEKT3",
        "hgnc": "HGNC:14293",
        "name": "tektin 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tekt3"
      },
      {
        "slug": "cfap61",
        "symbol": "CFAP61",
        "hgnc": "HGNC:15872",
        "name": "cilia and flagella associated protein 61",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap61"
      },
      {
        "slug": "fkbp6",
        "symbol": "FKBP6",
        "hgnc": "HGNC:3722",
        "name": "FKBP prolyl isomerase family member 6 (inactive)",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp6"
      },
      {
        "slug": "brwd1",
        "symbol": "BRWD1",
        "hgnc": "HGNC:12760",
        "name": "bromodomain and WD repeat domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brwd1"
      },
      {
        "slug": "catip",
        "symbol": "CATIP",
        "hgnc": "HGNC:25062",
        "name": "ciliogenesis associated TTC17 interacting protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/catip"
      },
      {
        "slug": "cfap20",
        "symbol": "CFAP20",
        "hgnc": "HGNC:29523",
        "name": "cilia and flagella associated protein 20",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap20"
      },
      {
        "slug": "cfap91",
        "symbol": "CFAP91",
        "hgnc": "HGNC:24010",
        "name": "cilia and flagella associated protein 91",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap91"
      },
      {
        "slug": "daz1",
        "symbol": "DAZ1",
        "hgnc": "HGNC:2682",
        "name": "deleted in azoospermia 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daz1"
      },
      {
        "slug": "daz2",
        "symbol": "DAZ2",
        "hgnc": "HGNC:15964",
        "name": "deleted in azoospermia 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daz2"
      },
      {
        "slug": "daz3",
        "symbol": "DAZ3",
        "hgnc": "HGNC:15965",
        "name": "deleted in azoospermia 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daz3"
      },
      {
        "slug": "daz4",
        "symbol": "DAZ4",
        "hgnc": "HGNC:15966",
        "name": "deleted in azoospermia 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daz4"
      },
      {
        "slug": "ddx3y",
        "symbol": "DDX3Y",
        "hgnc": "HGNC:2699",
        "name": "DEAD-box helicase 3 Y-linked",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx3y"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "hgnc": "HGNC:2941",
        "name": "dynein axonemal heavy chain 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah10"
      },
      {
        "slug": "dnhd1",
        "symbol": "DNHD1",
        "hgnc": "HGNC:26532",
        "name": "dynein heavy chain domain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnhd1"
      },
      {
        "slug": "fshb",
        "symbol": "FSHB",
        "hgnc": "HGNC:3964",
        "name": "follicle stimulating hormone subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fshb"
      },
      {
        "slug": "ift74",
        "symbol": "IFT74",
        "hgnc": "HGNC:21424",
        "name": "intraflagellar transport 74",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift74"
      },
      {
        "slug": "pdha2",
        "symbol": "PDHA2",
        "hgnc": "HGNC:8807",
        "name": "pyruvate dehydrogenase E1 subunit alpha 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdha2"
      },
      {
        "slug": "pmfbp1",
        "symbol": "PMFBP1",
        "hgnc": "HGNC:17728",
        "name": "polyamine modulated factor 1 binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmfbp1"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "rbmy1a1",
        "symbol": "RBMY1A1",
        "hgnc": "HGNC:9912",
        "name": "RNA binding motif protein Y-linked family 1 member A1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbmy1a1"
      },
      {
        "slug": "septin12",
        "symbol": "SEPTIN12",
        "hgnc": "HGNC:26348",
        "name": "septin 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/septin12"
      },
      {
        "slug": "sun5",
        "symbol": "SUN5",
        "hgnc": "HGNC:16252",
        "name": "Sad1 and UNC84 domain containing 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sun5"
      },
      {
        "slug": "tspy1",
        "symbol": "TSPY1",
        "hgnc": "HGNC:12381",
        "name": "testis specific protein Y-linked 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspy1"
      },
      {
        "slug": "usp9y",
        "symbol": "USP9Y",
        "hgnc": "HGNC:12633",
        "name": "ubiquitin specific peptidase 9 Y-linked",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp9y"
      },
      {
        "slug": "adgrg2",
        "symbol": "ADGRG2",
        "hgnc": "HGNC:4516",
        "name": "adhesion G protein-coupled receptor G2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adgrg2"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "antxr1",
        "symbol": "ANTXR1",
        "hgnc": "HGNC:21014",
        "name": "ANTXR cell adhesion molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/antxr1"
      },
      {
        "slug": "blm",
        "symbol": "BLM",
        "hgnc": "HGNC:1058",
        "name": "BLM RecQ like helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blm"
      },
      {
        "slug": "ccin",
        "symbol": "CCIN",
        "hgnc": "HGNC:1568",
        "name": "calicin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccin"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "dnah12",
        "symbol": "DNAH12",
        "hgnc": "HGNC:2943",
        "name": "dynein axonemal heavy chain 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah12"
      },
      {
        "slug": "lhcgr",
        "symbol": "LHCGR",
        "hgnc": "HGNC:6585",
        "name": "luteinizing hormone/choriogonadotropin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhcgr"
      },
      {
        "slug": "nr3c1",
        "symbol": "NR3C1",
        "hgnc": "HGNC:7978",
        "name": "nuclear receptor subfamily 3 group C member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr3c1"
      },
      {
        "slug": "pde11a",
        "symbol": "PDE11A",
        "hgnc": "HGNC:8773",
        "name": "phosphodiesterase 11A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde11a"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "stk33",
        "symbol": "STK33",
        "hgnc": "HGNC:14568",
        "name": "serine/threonine kinase 33",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk33"
      },
      {
        "slug": "armc2",
        "symbol": "ARMC2",
        "hgnc": "HGNC:23045",
        "name": "armadillo repeat containing 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/armc2"
      },
      {
        "slug": "cnbp",
        "symbol": "CNBP",
        "hgnc": "HGNC:13164",
        "name": "CCHC-type zinc finger nucleic acid binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnbp"
      },
      {
        "slug": "dnah17",
        "symbol": "DNAH17",
        "hgnc": "HGNC:2946",
        "name": "dynein axonemal heavy chain 17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah17"
      },
      {
        "slug": "msh4",
        "symbol": "MSH4",
        "hgnc": "HGNC:7327",
        "name": "mutS homolog 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh4"
      },
      {
        "slug": "nr5a1",
        "symbol": "NR5A1",
        "hgnc": "HGNC:7983",
        "name": "nuclear receptor subfamily 5 group A member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr5a1"
      },
      {
        "slug": "poc1a",
        "symbol": "POC1A",
        "hgnc": "HGNC:24488",
        "name": "POC1 centriolar protein A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/poc1a"
      }
    ]
  }
}