{
  "url": "https://dantelabs.com/traits/motor-regression",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "motor-regression",
    "id": "HP:0033044",
    "name": "Motor regression",
    "definition": "Loss of previously achieved motor skills, as manifested by loss of developmental motor milestones.",
    "synonyms": [
      "Regression of motor skills"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "developmental-regression",
        "name": "Loss of developmental milestones",
        "url": "https://dantelabs.com/traits/developmental-regression"
      }
    ],
    "narrower": [
      {
        "slug": "loss-of-acquired-purposeful-hand-skills",
        "name": "Loss of acquired purposeful hand skills",
        "genes": 1,
        "url": "https://dantelabs.com/traits/loss-of-acquired-purposeful-hand-skills"
      }
    ],
    "genes": [
      {
        "slug": "cox15",
        "symbol": "COX15",
        "hgnc": "HGNC:2263",
        "name": "cytochrome c oxidase assembly factor COX15",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox15"
      },
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "mal",
        "symbol": "MAL",
        "hgnc": "HGNC:6817",
        "name": "mal, T cell differentiation protein (MAL blood group)",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mal"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "opa1",
        "symbol": "OPA1",
        "hgnc": "HGNC:8140",
        "name": "OPA1 mitochondrial dynamin like GTPase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opa1"
      },
      {
        "slug": "polr3k",
        "symbol": "POLR3K",
        "hgnc": "HGNC:14121",
        "name": "RNA polymerase III subunit K",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3k"
      },
      {
        "slug": "snapc4",
        "symbol": "SNAPC4",
        "hgnc": "HGNC:11137",
        "name": "small nuclear RNA activating complex polypeptide 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snapc4"
      },
      {
        "slug": "adh5",
        "symbol": "ADH5",
        "hgnc": "HGNC:253",
        "name": "alcohol dehydrogenase 5 (class III), chi polypeptide",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adh5"
      },
      {
        "slug": "cln8",
        "symbol": "CLN8",
        "hgnc": "HGNC:2079",
        "name": "CLN8 transmembrane ER and ERGIC protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cln8"
      },
      {
        "slug": "eprs1",
        "symbol": "EPRS1",
        "hgnc": "HGNC:3418",
        "name": "glutamyl-prolyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eprs1"
      },
      {
        "slug": "msl2",
        "symbol": "MSL2",
        "hgnc": "HGNC:25544",
        "name": "MSL complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl2"
      },
      {
        "slug": "polr3gl",
        "symbol": "POLR3GL",
        "hgnc": "HGNC:28466",
        "name": "RNA polymerase III subunit GL",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3gl"
      },
      {
        "slug": "selenoi",
        "symbol": "SELENOI",
        "hgnc": "HGNC:29361",
        "name": "selenoprotein I",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/selenoi"
      },
      {
        "slug": "stn1",
        "symbol": "STN1",
        "hgnc": "HGNC:26200",
        "name": "STN1 subunit of CST complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stn1"
      },
      {
        "slug": "trappc6b",
        "symbol": "TRAPPC6B",
        "hgnc": "HGNC:23066",
        "name": "trafficking protein particle complex subunit 6B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc6b"
      },
      {
        "slug": "dph5",
        "symbol": "DPH5",
        "hgnc": "HGNC:24270",
        "name": "diphthamide biosynthesis 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph5"
      },
      {
        "slug": "hsd17b4",
        "symbol": "HSD17B4",
        "hgnc": "HGNC:5213",
        "name": "hydroxysteroid 17-beta dehydrogenase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b4"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "ndufa6",
        "symbol": "NDUFA6",
        "hgnc": "HGNC:7690",
        "name": "NADH:ubiquinone oxidoreductase subunit A6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa6"
      }
    ]
  }
}