{
  "url": "https://dantelabs.com/traits/lymph-node-hypoplasia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "lymph-node-hypoplasia",
    "id": "HP:0002732",
    "name": "Small lymph nodes",
    "label": "Lymph node hypoplasia",
    "definition": "Underdevelopment of the lymph nodes.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-lymph-node-morphology",
        "name": "Abnormal lymph node histology",
        "url": "https://dantelabs.com/traits/abnormal-lymph-node-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ephb4",
        "symbol": "EPHB4",
        "hgnc": "HGNC:3395",
        "name": "EPH receptor B4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ephb4"
      },
      {
        "slug": "il2rg",
        "symbol": "IL2RG",
        "hgnc": "HGNC:6010",
        "name": "interleukin 2 receptor subunit gamma",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rg"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "pnp",
        "symbol": "PNP",
        "hgnc": "HGNC:7892",
        "name": "purine nucleoside phosphorylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnp"
      }
    ]
  }
}