{
  "url": "https://dantelabs.com/traits/lower-limb-hyperreflexia",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "lower-limb-hyperreflexia",
    "id": "HP:0002395",
    "name": "Overactive lower leg reflex",
    "label": "Lower limb hyperreflexia",
    "definition": "Increased intensity of the a reflex in the leg.",
    "synonyms": [
      "Brisk lower extremity reflexes",
      "Hyperreflexia in lower limbs",
      "Hyperreflexia in the lower limbs",
      "Increased deep tendon reflexes in the lower limbs",
      "Leg hyperreflexia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "hyperreflexia",
        "name": "Increased reflexes",
        "url": "https://dantelabs.com/traits/hyperreflexia"
      }
    ],
    "narrower": [
      {
        "slug": "hyperactive-patellar-reflex",
        "name": "Brisk knee jerk",
        "genes": 20,
        "url": "https://dantelabs.com/traits/hyperactive-patellar-reflex"
      },
      {
        "slug": "hyperactive-achilles-reflex",
        "name": "Hyperactive Achilles reflex",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hyperactive-achilles-reflex"
      }
    ],
    "genes": [
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "amfr",
        "symbol": "AMFR",
        "hgnc": "HGNC:463",
        "name": "autocrine motility factor receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amfr"
      },
      {
        "slug": "capn1",
        "symbol": "CAPN1",
        "hgnc": "HGNC:1476",
        "name": "calpain 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/capn1"
      },
      {
        "slug": "cldn11",
        "symbol": "CLDN11",
        "hgnc": "HGNC:8514",
        "name": "claudin 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn11"
      },
      {
        "slug": "cyp2u1",
        "symbol": "CYP2U1",
        "hgnc": "HGNC:20582",
        "name": "cytochrome P450 family 2 subfamily U member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp2u1"
      },
      {
        "slug": "fars2",
        "symbol": "FARS2",
        "hgnc": "HGNC:21062",
        "name": "phenylalanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fars2"
      },
      {
        "slug": "glul",
        "symbol": "GLUL",
        "hgnc": "HGNC:4341",
        "name": "glutamate-ammonia ligase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glul"
      },
      {
        "slug": "hpdl",
        "symbol": "HPDL",
        "hgnc": "HGNC:28242",
        "name": "4-hydroxyphenylpyruvate dioxygenase like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpdl"
      },
      {
        "slug": "kif1a",
        "symbol": "KIF1A",
        "hgnc": "HGNC:888",
        "name": "kinesin family member 1A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kif1a"
      },
      {
        "slug": "klc4",
        "symbol": "KLC4",
        "hgnc": "HGNC:21624",
        "name": "kinesin light chain 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klc4"
      },
      {
        "slug": "kpna3",
        "symbol": "KPNA3",
        "hgnc": "HGNC:6396",
        "name": "karyopherin subunit alpha 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kpna3"
      },
      {
        "slug": "large1",
        "symbol": "LARGE1",
        "hgnc": "HGNC:6511",
        "name": "LARGE xylosyl- and glucuronyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/large1"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "reep2",
        "symbol": "REEP2",
        "hgnc": "HGNC:17975",
        "name": "receptor accessory protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/reep2"
      },
      {
        "slug": "rtn2",
        "symbol": "RTN2",
        "hgnc": "HGNC:10468",
        "name": "reticulon 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtn2"
      },
      {
        "slug": "selenoi",
        "symbol": "SELENOI",
        "hgnc": "HGNC:29361",
        "name": "selenoprotein I",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/selenoi"
      },
      {
        "slug": "spg7",
        "symbol": "SPG7",
        "hgnc": "HGNC:11237",
        "name": "SPG7 matrix AAA peptidase subunit, paraplegin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spg7"
      },
      {
        "slug": "tmem63c",
        "symbol": "TMEM63C",
        "hgnc": "HGNC:23787",
        "name": "transmembrane protein 63C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem63c"
      },
      {
        "slug": "ubap1",
        "symbol": "UBAP1",
        "hgnc": "HGNC:12461",
        "name": "ubiquitin associated protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap1"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "vldlr",
        "symbol": "VLDLR",
        "hgnc": "HGNC:12698",
        "name": "very low density lipoprotein receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vldlr"
      },
      {
        "slug": "vps11",
        "symbol": "VPS11",
        "hgnc": "HGNC:14583",
        "name": "VPS11 core subunit of CORVET and HOPS complexes",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps11"
      },
      {
        "slug": "washc5",
        "symbol": "WASHC5",
        "hgnc": "HGNC:28984",
        "name": "WASH complex subunit 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/washc5"
      },
      {
        "slug": "afg3l2",
        "symbol": "AFG3L2",
        "hgnc": "HGNC:315",
        "name": "AFG3 like matrix AAA peptidase subunit 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/afg3l2"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "coq4",
        "symbol": "COQ4",
        "hgnc": "HGNC:19693",
        "name": "coenzyme Q4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq4"
      },
      {
        "slug": "erlin1",
        "symbol": "ERLIN1",
        "hgnc": "HGNC:16947",
        "name": "ER lipid raft associated 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erlin1"
      },
      {
        "slug": "kif1c",
        "symbol": "KIF1C",
        "hgnc": "HGNC:6317",
        "name": "kinesin family member 1C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif1c"
      },
      {
        "slug": "kif5a",
        "symbol": "KIF5A",
        "hgnc": "HGNC:6323",
        "name": "kinesin family member 5A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif5a"
      },
      {
        "slug": "nipa1",
        "symbol": "NIPA1",
        "hgnc": "HGNC:17043",
        "name": "NIPA magnesium transporter 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nipa1"
      },
      {
        "slug": "spg11",
        "symbol": "SPG11",
        "hgnc": "HGNC:11226",
        "name": "SPG11 vesicle trafficking associated, spatacsin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spg11"
      },
      {
        "slug": "tnr",
        "symbol": "TNR",
        "hgnc": "HGNC:11953",
        "name": "tenascin R",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnr"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "dkk1",
        "symbol": "DKK1",
        "hgnc": "HGNC:2891",
        "name": "dickkopf Wnt signaling pathway inhibitor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkk1"
      },
      {
        "slug": "dlat",
        "symbol": "DLAT",
        "hgnc": "HGNC:2896",
        "name": "dihydrolipoamide S-acetyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlat"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "gch1",
        "symbol": "GCH1",
        "hgnc": "HGNC:4193",
        "name": "GTP cyclohydrolase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gch1"
      },
      {
        "slug": "ifrd1",
        "symbol": "IFRD1",
        "hgnc": "HGNC:5456",
        "name": "interferon related developmental regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifrd1"
      },
      {
        "slug": "impdh2",
        "symbol": "IMPDH2",
        "hgnc": "HGNC:6053",
        "name": "inosine monophosphate dehydrogenase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/impdh2"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "ky",
        "symbol": "KY",
        "hgnc": "HGNC:26576",
        "name": "kyphoscoliosis peptidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ky"
      },
      {
        "slug": "lyrm4",
        "symbol": "LYRM4",
        "hgnc": "HGNC:21365",
        "name": "LYR motif containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm4"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "mks1",
        "symbol": "MKS1",
        "hgnc": "HGNC:7121",
        "name": "MKS transition zone complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mks1"
      },
      {
        "slug": "msl3",
        "symbol": "MSL3",
        "hgnc": "HGNC:7370",
        "name": "MSL complex subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl3"
      },
      {
        "slug": "mt-te",
        "symbol": "MT-TE",
        "hgnc": "HGNC:7479",
        "name": "mitochondrially encoded tRNA-Glu (GAA/G)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-te"
      },
      {
        "slug": "mtrfr",
        "symbol": "MTRFR",
        "hgnc": "HGNC:26784",
        "name": "mitochondrial translation release factor in rescue",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtrfr"
      },
      {
        "slug": "nr4a2",
        "symbol": "NR4A2",
        "hgnc": "HGNC:7981",
        "name": "nuclear receptor subfamily 4 group A member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr4a2"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "rab3a",
        "symbol": "RAB3A",
        "hgnc": "HGNC:9777",
        "name": "RAB3A, member RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3a"
      },
      {
        "slug": "reep1",
        "symbol": "REEP1",
        "hgnc": "HGNC:25786",
        "name": "receptor accessory protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reep1"
      },
      {
        "slug": "rubcn",
        "symbol": "RUBCN",
        "hgnc": "HGNC:28991",
        "name": "rubicon autophagy regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rubcn"
      },
      {
        "slug": "th",
        "symbol": "TH",
        "hgnc": "HGNC:11782",
        "name": "tyrosine hydroxylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/th"
      },
      {
        "slug": "tspoap1",
        "symbol": "TSPOAP1",
        "hgnc": "HGNC:16831",
        "name": "TSPO associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspoap1"
      },
      {
        "slug": "ube3a",
        "symbol": "UBE3A",
        "hgnc": "HGNC:12496",
        "name": "ubiquitin protein ligase E3A",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ube3a"
      },
      {
        "slug": "uchl1",
        "symbol": "UCHL1",
        "hgnc": "HGNC:12513",
        "name": "ubiquitin C-terminal hydrolase L1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uchl1"
      },
      {
        "slug": "usp8",
        "symbol": "USP8",
        "hgnc": "HGNC:12631",
        "name": "ubiquitin specific peptidase 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp8"
      },
      {
        "slug": "zfyve26",
        "symbol": "ZFYVE26",
        "hgnc": "HGNC:20761",
        "name": "zinc finger FYVE-type containing 26",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfyve26"
      },
      {
        "slug": "ftl",
        "symbol": "FTL",
        "hgnc": "HGNC:3999",
        "name": "ferritin light chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ftl"
      },
      {
        "slug": "gjb1",
        "symbol": "GJB1",
        "hgnc": "HGNC:4283",
        "name": "gap junction protein beta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gjb1"
      },
      {
        "slug": "plxna1",
        "symbol": "PLXNA1",
        "hgnc": "HGNC:9099",
        "name": "plexin A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plxna1"
      },
      {
        "slug": "rars1",
        "symbol": "RARS1",
        "hgnc": "HGNC:9870",
        "name": "arginyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars1"
      },
      {
        "slug": "syne1",
        "symbol": "SYNE1",
        "hgnc": "HGNC:17089",
        "name": "spectrin repeat containing nuclear envelope protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syne1"
      },
      {
        "slug": "taf1",
        "symbol": "TAF1",
        "hgnc": "HGNC:11535",
        "name": "TATA-box binding protein associated factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf1"
      },
      {
        "slug": "trrap",
        "symbol": "TRRAP",
        "hgnc": "HGNC:12347",
        "name": "transformation/transcription domain associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trrap"
      },
      {
        "slug": "ufc1",
        "symbol": "UFC1",
        "hgnc": "HGNC:26941",
        "name": "ubiquitin-fold modifier conjugating enzyme 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufc1"
      },
      {
        "slug": "znf142",
        "symbol": "ZNF142",
        "hgnc": "HGNC:12927",
        "name": "zinc finger protein 142",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf142"
      },
      {
        "slug": "sptan1",
        "symbol": "SPTAN1",
        "hgnc": "HGNC:11273",
        "name": "spectrin alpha, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptan1"
      },
      {
        "slug": "apoe",
        "symbol": "APOE",
        "hgnc": "HGNC:613",
        "name": "apolipoprotein E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoe"
      },
      {
        "slug": "dpm1",
        "symbol": "DPM1",
        "hgnc": "HGNC:3005",
        "name": "dolichyl-phosphate mannosyltransferase subunit 1, catalytic",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpm1"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "pde8b",
        "symbol": "PDE8B",
        "hgnc": "HGNC:8794",
        "name": "phosphodiesterase 8B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde8b"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "slc33a1",
        "symbol": "SLC33A1",
        "hgnc": "HGNC:95",
        "name": "solute carrier family 33 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc33a1"
      },
      {
        "slug": "st3gal5",
        "symbol": "ST3GAL5",
        "hgnc": "HGNC:10872",
        "name": "ST3 beta-galactoside alpha-2,3-sialyltransferase 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/st3gal5"
      },
      {
        "slug": "sumf1",
        "symbol": "SUMF1",
        "hgnc": "HGNC:20376",
        "name": "sulfatase modifying factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sumf1"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      }
    ]
  }
}