{
  "url": "https://dantelabs.com/traits/large-placenta",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "large-placenta",
    "id": "HP:0006267",
    "name": "Large placenta",
    "definition": "Increased size of the placenta.",
    "synonyms": [
      "Placental enlargement"
    ],
    "systems": [
      {
        "slug": "abnormality-of-prenatal-development-or-birth",
        "name": "Abnormality of prenatal development or birth",
        "url": "https://dantelabs.com/traits/abnormality-of-prenatal-development-or-birth"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-placental-size",
        "name": "Abnormal placental size",
        "url": "https://dantelabs.com/traits/abnormal-placental-size"
      }
    ],
    "narrower": [
      {
        "slug": "hydropic-placenta",
        "name": "Hydropic placenta",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hydropic-placenta"
      }
    ],
    "genes": [
      {
        "slug": "dlk1",
        "symbol": "DLK1",
        "hgnc": "HGNC:2907",
        "name": "delta like non-canonical Notch ligand 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dlk1"
      },
      {
        "slug": "meg3",
        "symbol": "MEG3",
        "hgnc": "HGNC:14575",
        "name": "maternally expressed 3",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/meg3"
      },
      {
        "slug": "rtl1",
        "symbol": "RTL1",
        "hgnc": "HGNC:14665",
        "name": "retrotransposon Gag like 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/rtl1"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "mks1",
        "symbol": "MKS1",
        "hgnc": "HGNC:7121",
        "name": "MKS transition zone complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mks1"
      },
      {
        "slug": "skic3",
        "symbol": "SKIC3",
        "hgnc": "HGNC:23639",
        "name": "SKI3 subunit of superkiller complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/skic3"
      }
    ]
  }
}