{
  "url": "https://dantelabs.com/traits/large-knee",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "large-knee",
    "id": "HP:0030866",
    "name": "Large knee",
    "definition": "Abnormally increased size of the knee joint.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-knee-morphology",
        "name": "Abnormal knee morphology",
        "url": "https://dantelabs.com/traits/abnormal-knee-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mia3",
        "symbol": "MIA3",
        "hgnc": "HGNC:24008",
        "name": "MIA SH3 domain ER export factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mia3"
      },
      {
        "slug": "slc13a1",
        "symbol": "SLC13A1",
        "hgnc": "HGNC:10916",
        "name": "solute carrier family 13 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc13a1"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "idh1",
        "symbol": "IDH1",
        "hgnc": "HGNC:5382",
        "name": "isocitrate dehydrogenase (NADP(+)) 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh1"
      }
    ]
  }
}