{
  "url": "https://dantelabs.com/traits/large-joint-hypermobility",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "large-joint-hypermobility",
    "id": "HP:0430047",
    "name": "Large joint hypermobility",
    "definition": "The capability that a large joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes. Large joints include shoulders, elbows, hips, knees, and ankles.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      }
    ],
    "narrower": [
      {
        "slug": "knee-joint-hypermobility",
        "name": "Knee joint over-flexibility",
        "genes": 5,
        "url": "https://dantelabs.com/traits/knee-joint-hypermobility"
      },
      {
        "slug": "hip-joint-hypermobility",
        "name": "Hip joint hypermobility",
        "genes": 3,
        "url": "https://dantelabs.com/traits/hip-joint-hypermobility"
      }
    ],
    "genes": [
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "fkbp14",
        "symbol": "FKBP14",
        "hgnc": "HGNC:18625",
        "name": "FKBP prolyl isomerase 14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp14"
      },
      {
        "slug": "emilin1",
        "symbol": "EMILIN1",
        "hgnc": "HGNC:19880",
        "name": "elastin microfibril interfacer 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emilin1"
      }
    ]
  }
}