{
  "url": "https://dantelabs.com/traits/ketosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ketosis",
    "id": "HP:0001946",
    "name": "High levels of ketone bodies",
    "label": "Ketosis",
    "definition": "Presence of elevated levels of ketone bodies in the body.",
    "synonyms": [
      "Hyperketosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "ketoacidosis",
        "name": "Ketoacidosis",
        "genes": 21,
        "url": "https://dantelabs.com/traits/ketoacidosis"
      },
      {
        "slug": "hyperketonemia",
        "name": "Increased level of ketone bodies in blood",
        "genes": 6,
        "url": "https://dantelabs.com/traits/hyperketonemia"
      }
    ],
    "genes": [
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "kars1",
        "symbol": "KARS1",
        "hgnc": "HGNC:6215",
        "name": "lysyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kars1"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "mdga2",
        "symbol": "MDGA2",
        "hgnc": "HGNC:19835",
        "name": "MAM domain containing glycosylphosphatidylinositol anchor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdga2"
      },
      {
        "slug": "ghsr",
        "symbol": "GHSR",
        "hgnc": "HGNC:4267",
        "name": "growth hormone secretagogue receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ghsr"
      },
      {
        "slug": "gys2",
        "symbol": "GYS2",
        "hgnc": "HGNC:4707",
        "name": "glycogen synthase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gys2"
      },
      {
        "slug": "lyrm4",
        "symbol": "LYRM4",
        "hgnc": "HGNC:21365",
        "name": "LYR motif containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm4"
      },
      {
        "slug": "phka2",
        "symbol": "PHKA2",
        "hgnc": "HGNC:8926",
        "name": "phosphorylase kinase regulatory subunit alpha 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phka2"
      },
      {
        "slug": "phkg2",
        "symbol": "PHKG2",
        "hgnc": "HGNC:8931",
        "name": "phosphorylase kinase catalytic subunit gamma 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phkg2"
      },
      {
        "slug": "polr3k",
        "symbol": "POLR3K",
        "hgnc": "HGNC:14121",
        "name": "RNA polymerase III subunit K",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3k"
      },
      {
        "slug": "pygl",
        "symbol": "PYGL",
        "hgnc": "HGNC:9725",
        "name": "glycogen phosphorylase L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pygl"
      },
      {
        "slug": "acadm",
        "symbol": "ACADM",
        "hgnc": "HGNC:89",
        "name": "acyl-CoA dehydrogenase medium chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acadm"
      },
      {
        "slug": "fbp1",
        "symbol": "FBP1",
        "hgnc": "HGNC:3606",
        "name": "fructose-bisphosphatase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fbp1"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "mlycd",
        "symbol": "MLYCD",
        "hgnc": "HGNC:7150",
        "name": "malonyl-CoA decarboxylase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mlycd"
      },
      {
        "slug": "ppp1r15b",
        "symbol": "PPP1R15B",
        "hgnc": "HGNC:14951",
        "name": "protein phosphatase 1 regulatory subunit 15B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1r15b"
      },
      {
        "slug": "slc5a2",
        "symbol": "SLC5A2",
        "hgnc": "HGNC:11037",
        "name": "solute carrier family 5 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a2"
      },
      {
        "slug": "trmt10a",
        "symbol": "TRMT10A",
        "hgnc": "HGNC:28403",
        "name": "tRNA methyltransferase 10A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10a"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "abhd5",
        "symbol": "ABHD5",
        "hgnc": "HGNC:21396",
        "name": "abhydrolase domain containing 5, lysophosphatidic acid acyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abhd5"
      },
      {
        "slug": "bckdha",
        "symbol": "BCKDHA",
        "hgnc": "HGNC:986",
        "name": "branched chain keto acid dehydrogenase E1 subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bckdha"
      },
      {
        "slug": "gcdh",
        "symbol": "GCDH",
        "hgnc": "HGNC:4189",
        "name": "glutaryl-CoA dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcdh"
      },
      {
        "slug": "mmaa",
        "symbol": "MMAA",
        "hgnc": "HGNC:18871",
        "name": "metabolism of cobalamin associated A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmaa"
      },
      {
        "slug": "mmab",
        "symbol": "MMAB",
        "hgnc": "HGNC:19331",
        "name": "metabolism of cobalamin associated B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmab"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      }
    ]
  }
}