{
  "url": "https://dantelabs.com/traits/hypoplastic-pubic-bone",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoplastic-pubic-bone",
    "id": "HP:0003173",
    "name": "Hypoplastic pubic bone",
    "definition": "Underdevelopment of the pubis, which together with the ilium and the ischium, is one of the three bones that make up the hip bone.",
    "synonyms": [
      "Hypoplastic pubic bones",
      "Hypoplastic pubis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-pubic-bone",
        "name": "Absent/small pubic bones",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-pubic-bone"
      }
    ],
    "narrower": [
      {
        "slug": "hypoplastic-pubic-ramus",
        "name": "Hypoplastic pubic ramus",
        "genes": 6,
        "url": "https://dantelabs.com/traits/hypoplastic-pubic-ramus"
      },
      {
        "slug": "hypoplastic-ischiopubic-ramus",
        "name": "Hypoplastic ischiopubic ramus",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypoplastic-ischiopubic-ramus"
      }
    ],
    "genes": [
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "intu",
        "symbol": "INTU",
        "hgnc": "HGNC:29239",
        "name": "inturned planar cell polarity protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/intu"
      },
      {
        "slug": "ccdc8",
        "symbol": "CCDC8",
        "hgnc": "HGNC:25367",
        "name": "coiled-coil domain containing 8 subunit of 3M complex",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc8"
      },
      {
        "slug": "cul7",
        "symbol": "CUL7",
        "hgnc": "HGNC:21024",
        "name": "cullin 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul7"
      },
      {
        "slug": "inppl1",
        "symbol": "INPPL1",
        "hgnc": "HGNC:6080",
        "name": "inositol polyphosphate phosphatase like 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/inppl1"
      },
      {
        "slug": "obsl1",
        "symbol": "OBSL1",
        "hgnc": "HGNC:29092",
        "name": "obscurin like cytoskeletal adaptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/obsl1"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "hspg2",
        "symbol": "HSPG2",
        "hgnc": "HGNC:5273",
        "name": "heparan sulfate proteoglycan 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspg2"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "matn3",
        "symbol": "MATN3",
        "hgnc": "HGNC:6909",
        "name": "matrilin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/matn3"
      },
      {
        "slug": "tbx15",
        "symbol": "TBX15",
        "hgnc": "HGNC:11594",
        "name": "T-box transcription factor 15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx15"
      }
    ]
  }
}