{
  "url": "https://dantelabs.com/traits/hand-tremor",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hand-tremor",
    "id": "HP:0002378",
    "name": "Hand tremor",
    "definition": "An unintentional, oscillating to-and-fro muscle movement affecting the hand.",
    "synonyms": [
      "Tremor of hand",
      "Tremor of hands",
      "tremors in hands"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "tremor-by-anatomical-site",
        "name": "Tremor of a body part",
        "url": "https://dantelabs.com/traits/tremor-by-anatomical-site"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "gtpbp1",
        "symbol": "GTPBP1",
        "hgnc": "HGNC:4669",
        "name": "GTP binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp1"
      },
      {
        "slug": "kcnn2",
        "symbol": "KCNN2",
        "hgnc": "HGNC:6291",
        "name": "potassium calcium-activated channel subfamily N member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn2"
      },
      {
        "slug": "lrrc7",
        "symbol": "LRRC7",
        "hgnc": "HGNC:18531",
        "name": "leucine rich repeat containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc7"
      },
      {
        "slug": "rab32",
        "symbol": "RAB32",
        "hgnc": "HGNC:9772",
        "name": "RAB32, member RAS oncogene family",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab32"
      },
      {
        "slug": "rab3a",
        "symbol": "RAB3A",
        "hgnc": "HGNC:9777",
        "name": "RAB3A, member RAS oncogene family",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3a"
      },
      {
        "slug": "slc6a17",
        "symbol": "SLC6A17",
        "hgnc": "HGNC:31399",
        "name": "solute carrier family 6 member 17",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc6a17"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "tor1a",
        "symbol": "TOR1A",
        "hgnc": "HGNC:3098",
        "name": "torsin family 1 member A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tor1a"
      },
      {
        "slug": "adra2b",
        "symbol": "ADRA2B",
        "hgnc": "HGNC:282",
        "name": "adrenoceptor alpha 2B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adra2b"
      },
      {
        "slug": "cntn2",
        "symbol": "CNTN2",
        "hgnc": "HGNC:2172",
        "name": "contactin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntn2"
      },
      {
        "slug": "ctnnd2",
        "symbol": "CTNND2",
        "hgnc": "HGNC:2516",
        "name": "catenin delta 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnd2"
      },
      {
        "slug": "marchf6",
        "symbol": "MARCHF6",
        "hgnc": "HGNC:30550",
        "name": "membrane associated ring-CH-type finger 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/marchf6"
      },
      {
        "slug": "pdk3",
        "symbol": "PDK3",
        "hgnc": "HGNC:8811",
        "name": "pyruvate dehydrogenase kinase 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdk3"
      },
      {
        "slug": "rapgef2",
        "symbol": "RAPGEF2",
        "hgnc": "HGNC:16854",
        "name": "Rap guanine nucleotide exchange factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rapgef2"
      },
      {
        "slug": "samd12",
        "symbol": "SAMD12",
        "hgnc": "HGNC:31750",
        "name": "sterile alpha motif domain containing 12",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samd12"
      },
      {
        "slug": "smn1",
        "symbol": "SMN1",
        "hgnc": "HGNC:11117",
        "name": "survival of motor neuron 1, telomeric",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/smn1"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "tnrc6a",
        "symbol": "TNRC6A",
        "hgnc": "HGNC:11969",
        "name": "trinucleotide repeat containing adaptor 6A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnrc6a"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "yeats2",
        "symbol": "YEATS2",
        "hgnc": "HGNC:25489",
        "name": "YEATS domain containing 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yeats2"
      },
      {
        "slug": "camta1",
        "symbol": "CAMTA1",
        "hgnc": "HGNC:18806",
        "name": "calmodulin binding transcription activator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camta1"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "hgnc": "HGNC:4195",
        "name": "glucokinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gck"
      },
      {
        "slug": "gjb1",
        "symbol": "GJB1",
        "hgnc": "HGNC:4283",
        "name": "gap junction protein beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb1"
      },
      {
        "slug": "gtpbp2",
        "symbol": "GTPBP2",
        "hgnc": "HGNC:4670",
        "name": "GTP binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp2"
      },
      {
        "slug": "mars1",
        "symbol": "MARS1",
        "hgnc": "HGNC:6898",
        "name": "methionyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mars1"
      },
      {
        "slug": "mfn2",
        "symbol": "MFN2",
        "hgnc": "HGNC:16877",
        "name": "mitofusin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mfn2"
      },
      {
        "slug": "nefl",
        "symbol": "NEFL",
        "hgnc": "HGNC:7739",
        "name": "neurofilament light chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefl"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "pmp2",
        "symbol": "PMP2",
        "hgnc": "HGNC:9117",
        "name": "peripheral myelin protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp2"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "rab3gap2",
        "symbol": "RAB3GAP2",
        "hgnc": "HGNC:17168",
        "name": "RAB3 GTPase activating non-catalytic protein subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3gap2"
      },
      {
        "slug": "taf1",
        "symbol": "TAF1",
        "hgnc": "HGNC:11535",
        "name": "TATA-box binding protein associated factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf1"
      },
      {
        "slug": "trappc6b",
        "symbol": "TRAPPC6B",
        "hgnc": "HGNC:23066",
        "name": "trafficking protein particle complex subunit 6B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc6b"
      },
      {
        "slug": "vrk1",
        "symbol": "VRK1",
        "hgnc": "HGNC:12718",
        "name": "VRK serine/threonine kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vrk1"
      },
      {
        "slug": "zfr",
        "symbol": "ZFR",
        "hgnc": "HGNC:17277",
        "name": "zinc finger RNA binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfr"
      },
      {
        "slug": "aars2",
        "symbol": "AARS2",
        "hgnc": "HGNC:21022",
        "name": "alanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars2"
      },
      {
        "slug": "ano3",
        "symbol": "ANO3",
        "hgnc": "HGNC:14004",
        "name": "anoctamin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano3"
      },
      {
        "slug": "erlin2",
        "symbol": "ERLIN2",
        "hgnc": "HGNC:1356",
        "name": "ER lipid raft associated 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/erlin2"
      },
      {
        "slug": "fgf14",
        "symbol": "FGF14",
        "hgnc": "HGNC:3671",
        "name": "fibroblast growth factor 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf14"
      },
      {
        "slug": "gba2",
        "symbol": "GBA2",
        "hgnc": "HGNC:18986",
        "name": "glucosylceramidase beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba2"
      },
      {
        "slug": "phip",
        "symbol": "PHIP",
        "hgnc": "HGNC:15673",
        "name": "PHIP subunit of CUL4-Ring ligase complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phip"
      },
      {
        "slug": "stub1",
        "symbol": "STUB1",
        "hgnc": "HGNC:11427",
        "name": "STIP1 homology and U-box containing protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stub1"
      },
      {
        "slug": "tfg",
        "symbol": "TFG",
        "hgnc": "HGNC:11758",
        "name": "trafficking from ER to golgi regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfg"
      },
      {
        "slug": "zfyve26",
        "symbol": "ZFYVE26",
        "hgnc": "HGNC:20761",
        "name": "zinc finger FYVE-type containing 26",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfyve26"
      },
      {
        "slug": "nop56",
        "symbol": "NOP56",
        "hgnc": "HGNC:15911",
        "name": "NOP56 ribonucleoprotein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nop56"
      },
      {
        "slug": "pdgfb",
        "symbol": "PDGFB",
        "hgnc": "HGNC:8800",
        "name": "platelet derived growth factor subunit B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfb"
      },
      {
        "slug": "abcb6",
        "symbol": "ABCB6",
        "hgnc": "HGNC:47",
        "name": "ATP binding cassette subfamily B member 6 (LAN blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb6"
      },
      {
        "slug": "drd3",
        "symbol": "DRD3",
        "hgnc": "HGNC:3024",
        "name": "dopamine receptor D3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drd3"
      },
      {
        "slug": "smn2",
        "symbol": "SMN2",
        "hgnc": "HGNC:11118",
        "name": "survival of motor neuron 2, centromeric",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smn2"
      }
    ]
  }
}