{
  "url": "https://dantelabs.com/traits/crazy-paving-pattern",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "crazy-paving-pattern",
    "id": "HP:0025391",
    "name": "Crazy paving pattern",
    "definition": "The so-called crazy paving pattern appears as thickened interlobular septa and intralobular lines superimposed on a background of ground-glass opacity, resembling irregularly shaped paving stones. The crazy-paving pattern is often sharply demarcated from more normal lung and may have a geographic outline. It was originally reported in patients with alveolar proteinosis and is also encountered in other diffuse lung diseases that affect both the interstitial and airspace compartments, such as lipoid pneumonia.",
    "synonyms": [
      "Crazy paving pattern on pulmonary HRCT",
      "Crazy-paving pattern"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "pulmonary-interstitial-high-resolution-computed-tomography-abnormality",
        "name": "Pulmonary interstitial high-resolution computed tomography abnormality",
        "url": "https://dantelabs.com/traits/pulmonary-interstitial-high-resolution-computed-tomography-abnormality"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "csf2ra",
        "symbol": "CSF2RA",
        "hgnc": "HGNC:2435",
        "name": "colony stimulating factor 2 receptor subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2ra"
      },
      {
        "slug": "csf2rb",
        "symbol": "CSF2RB",
        "hgnc": "HGNC:2436",
        "name": "colony stimulating factor 2 receptor subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2rb"
      },
      {
        "slug": "abca3",
        "symbol": "ABCA3",
        "hgnc": "HGNC:33",
        "name": "ATP binding cassette subfamily A member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca3"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      }
    ]
  }
}