{
  "url": "https://dantelabs.com/traits/crackles",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "crackles",
    "id": "HP:0030830",
    "name": "Crackles",
    "definition": "Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.",
    "synonyms": [
      "Crepitations",
      "Rales"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-breath-sound",
        "name": "Abnormal breath sound",
        "url": "https://dantelabs.com/traits/abnormal-breath-sound"
      }
    ],
    "narrower": [
      {
        "slug": "inspiratory-crackles",
        "name": "Inspiratory crackles",
        "genes": 1,
        "url": "https://dantelabs.com/traits/inspiratory-crackles"
      }
    ],
    "genes": [
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "abca3",
        "symbol": "ABCA3",
        "hgnc": "HGNC:33",
        "name": "ATP binding cassette subfamily A member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca3"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "hgnc": "HGNC:13552",
        "name": "ATPase phospholipid transporting 11A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp11a"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "dpp9",
        "symbol": "DPP9",
        "hgnc": "HGNC:18648",
        "name": "dipeptidyl peptidase 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpp9"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "fam13a",
        "symbol": "FAM13A",
        "hgnc": "HGNC:19367",
        "name": "family with sequence similarity 13 member A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam13a"
      },
      {
        "slug": "muc5b",
        "symbol": "MUC5B",
        "hgnc": "HGNC:7516",
        "name": "mucin 5B, oligomeric mucus/gel-forming",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/muc5b"
      },
      {
        "slug": "parn",
        "symbol": "PARN",
        "hgnc": "HGNC:8609",
        "name": "poly(A)-specific ribonuclease",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/parn"
      },
      {
        "slug": "rtel1",
        "symbol": "RTEL1",
        "hgnc": "HGNC:15888",
        "name": "regulator of telomere elongation helicase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtel1"
      },
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "hgnc": "HGNC:10600",
        "name": "sodium channel epithelial 1 subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1b"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "hgnc": "HGNC:10602",
        "name": "sodium channel epithelial 1 subunit gamma",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1g"
      },
      {
        "slug": "sftpa1",
        "symbol": "SFTPA1",
        "hgnc": "HGNC:10798",
        "name": "surfactant protein A1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sftpa1"
      },
      {
        "slug": "sftpa2",
        "symbol": "SFTPA2",
        "hgnc": "HGNC:10799",
        "name": "surfactant protein A2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sftpa2"
      },
      {
        "slug": "sftpc",
        "symbol": "SFTPC",
        "hgnc": "HGNC:10802",
        "name": "surfactant protein C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sftpc"
      },
      {
        "slug": "stn1",
        "symbol": "STN1",
        "hgnc": "HGNC:26200",
        "name": "STN1 subunit of CST complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stn1"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "agr2",
        "symbol": "AGR2",
        "hgnc": "HGNC:328",
        "name": "anterior gradient 2, protein disulphide isomerase family member",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agr2"
      },
      {
        "slug": "csf2ra",
        "symbol": "CSF2RA",
        "hgnc": "HGNC:2435",
        "name": "colony stimulating factor 2 receptor subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2ra"
      },
      {
        "slug": "csf2rb",
        "symbol": "CSF2RB",
        "hgnc": "HGNC:2436",
        "name": "colony stimulating factor 2 receptor subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2rb"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      }
    ]
  }
}