{
  "url": "https://dantelabs.com/traits/common-atrium",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "common-atrium",
    "id": "HP:0011565",
    "name": "Common atrium",
    "definition": "Complete absence of the interatrial septum with common atrioventricular valve and two atrioventricular connections.",
    "synonyms": [
      "Single atrium"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiac-atrium-morphology",
        "name": "Abnormality of heart atrium",
        "url": "https://dantelabs.com/traits/abnormal-cardiac-atrium-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gdf1",
        "symbol": "GDF1",
        "hgnc": "HGNC:4214",
        "name": "growth differentiation factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf1"
      },
      {
        "slug": "uggt1",
        "symbol": "UGGT1",
        "hgnc": "HGNC:15663",
        "name": "UDP-glucose glycoprotein glucosyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uggt1"
      },
      {
        "slug": "acvr2b",
        "symbol": "ACVR2B",
        "hgnc": "HGNC:174",
        "name": "activin A receptor type 2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr2b"
      },
      {
        "slug": "cfap53",
        "symbol": "CFAP53",
        "hgnc": "HGNC:26530",
        "name": "cilia and flagella associated protein 53",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap53"
      },
      {
        "slug": "clxn",
        "symbol": "CLXN",
        "hgnc": "HGNC:25678",
        "name": "calaxin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clxn"
      },
      {
        "slug": "prkacb",
        "symbol": "PRKACB",
        "hgnc": "HGNC:9381",
        "name": "protein kinase cAMP-activated catalytic subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkacb"
      },
      {
        "slug": "cirop",
        "symbol": "CIROP",
        "hgnc": "HGNC:53647",
        "name": "ciliated left-right organizer metallopeptidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cirop"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "evc",
        "symbol": "EVC",
        "hgnc": "HGNC:3497",
        "name": "EvC ciliary complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc"
      },
      {
        "slug": "evc2",
        "symbol": "EVC2",
        "hgnc": "HGNC:19747",
        "name": "EvC ciliary complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc2"
      },
      {
        "slug": "mmp21",
        "symbol": "MMP21",
        "hgnc": "HGNC:14357",
        "name": "matrix metallopeptidase 21",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp21"
      },
      {
        "slug": "zic3",
        "symbol": "ZIC3",
        "hgnc": "HGNC:12874",
        "name": "Zic family zinc finger 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic3"
      }
    ]
  }
}