{
  "url": "https://dantelabs.com/traits/abnormal-systemic-arterial-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-systemic-arterial-morphology",
    "id": "HP:0011004",
    "name": "Abnormal systemic arterial morphology",
    "definition": "An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries.",
    "synonyms": [
      "Abnormal systemic artery morphology",
      "Abnormality of the systemic arterial tree",
      "Systemic artery abnormality"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-blood-vessel-morphology",
        "name": "Abnormal blood vessel morphology",
        "url": "https://dantelabs.com/traits/abnormal-blood-vessel-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-carotid-artery-morphology",
        "name": "Abnormal carotid artery morphology",
        "genes": 43,
        "url": "https://dantelabs.com/traits/abnormal-carotid-artery-morphology"
      },
      {
        "slug": "abnormal-aortic-morphology",
        "name": "Abnormal aortic morphology",
        "genes": 36,
        "url": "https://dantelabs.com/traits/abnormal-aortic-morphology"
      },
      {
        "slug": "arterial-stenosis",
        "name": "Narrowing of an artery",
        "genes": 32,
        "url": "https://dantelabs.com/traits/arterial-stenosis"
      },
      {
        "slug": "arterial-dissection",
        "name": "Arterial dissection",
        "genes": 14,
        "url": "https://dantelabs.com/traits/arterial-dissection"
      },
      {
        "slug": "arterial-tortuosity",
        "name": "Arterial tortuosity",
        "genes": 10,
        "url": "https://dantelabs.com/traits/arterial-tortuosity"
      },
      {
        "slug": "arteriosclerosis",
        "name": "Hardened artery wall",
        "genes": 9,
        "url": "https://dantelabs.com/traits/arteriosclerosis"
      },
      {
        "slug": "arteritis",
        "name": "Inflammation of artery",
        "genes": 6,
        "url": "https://dantelabs.com/traits/arteritis"
      },
      {
        "slug": "arterial-calcification",
        "name": "Arterial calcification",
        "genes": 3,
        "url": "https://dantelabs.com/traits/arterial-calcification"
      },
      {
        "slug": "abnormal-subclavian-artery-morphology",
        "name": "Abnormal subclavian artery morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-subclavian-artery-morphology"
      },
      {
        "slug": "abnormal-retinal-arterial-arteriolar-morphology",
        "name": "Abnormality of retinal arteries",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-retinal-arterial-arteriolar-morphology"
      },
      {
        "slug": "arterial-fibromuscular-dysplasia",
        "name": "Arterial fibromuscular dysplasia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/arterial-fibromuscular-dysplasia"
      },
      {
        "slug": "abnormal-coronary-artery-morphology",
        "name": "Abnormal coronary artery morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-coronary-artery-morphology"
      },
      {
        "slug": "abnormal-cerebral-artery-morphology",
        "name": "Abnormality of cerebral artery",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-cerebral-artery-morphology"
      },
      {
        "slug": "arterial-intimal-fibrosis",
        "name": "Arterial intimal fibrosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/arterial-intimal-fibrosis"
      },
      {
        "slug": "basilar-artery-fenestration",
        "name": "Basilar artery fenestration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/basilar-artery-fenestration"
      },
      {
        "slug": "cystic-medial-necrosis",
        "name": "Cystic medial necrosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/cystic-medial-necrosis"
      },
      {
        "slug": "dilatation-of-an-abdominal-artery",
        "name": "Dilatation of an abdominal artery",
        "genes": 1,
        "url": "https://dantelabs.com/traits/dilatation-of-an-abdominal-artery"
      },
      {
        "slug": "abnormal-abdominal-aorta-branch-artery-morphology",
        "name": "Abnormal abdominal aorta branch artery morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-abdominal-aorta-branch-artery-morphology"
      },
      {
        "slug": "abnormal-bronchial-artery-morphology",
        "name": "Abnormal bronchial artery morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-bronchial-artery-morphology"
      },
      {
        "slug": "abnormal-femoral-artery-morphology",
        "name": "Abnormal femoral artery morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-femoral-artery-morphology"
      },
      {
        "slug": "abnormal-radial-artery-morphology",
        "name": "Abnormal radial artery morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-radial-artery-morphology"
      },
      {
        "slug": "abnormal-vertebral-artery-morphology",
        "name": "Abnormal vertebral artery morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-vertebral-artery-morphology"
      }
    ],
    "genes": [
      {
        "slug": "efemp2",
        "symbol": "EFEMP2",
        "hgnc": "HGNC:3219",
        "name": "EGF-like fibulin extracellular matrix protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp2"
      },
      {
        "slug": "fbln5",
        "symbol": "FBLN5",
        "hgnc": "HGNC:3602",
        "name": "fibulin 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbln5"
      },
      {
        "slug": "ltbp1",
        "symbol": "LTBP1",
        "hgnc": "HGNC:6714",
        "name": "latent transforming growth factor beta binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltbp1"
      },
      {
        "slug": "alg5",
        "symbol": "ALG5",
        "hgnc": "HGNC:20266",
        "name": "ALG5 dolichyl-phosphate beta-glucosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg5"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "bicc1",
        "symbol": "BICC1",
        "hgnc": "HGNC:19351",
        "name": "BicC family RNA binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicc1"
      },
      {
        "slug": "dnajb11",
        "symbol": "DNAJB11",
        "hgnc": "HGNC:14889",
        "name": "DnaJ heat shock protein family (Hsp40) member B11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb11"
      },
      {
        "slug": "ganab",
        "symbol": "GANAB",
        "hgnc": "HGNC:4138",
        "name": "glucosidase II alpha subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ganab"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pkd1",
        "symbol": "PKD1",
        "hgnc": "HGNC:9008",
        "name": "polycystin 1, transient receptor potential channel interacting",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd2"
      }
    ]
  }
}