{
  "url": "https://dantelabs.com/et/genes/rras",
  "gene": {
    "slug": "rras",
    "symbol": "RRAS",
    "name": "RAS related",
    "hgnc": "HGNC:10447",
    "summary": null,
    "location": "19q13.33",
    "locusType": "gene with protein product",
    "aliases": [
      "R-Ras",
      "RRAS1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000126458",
    "entrezId": 6237,
    "omim": [
      "165090"
    ],
    "uniprot": [
      "P10301"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "19",
      "start": 49635292,
      "end": 49640143,
      "strand": "-",
      "ensemblTranscript": "ENST00000246792.4",
      "refseqTranscript": "NM_006270.5",
      "ensemblProtein": "ENSP00000246792.2",
      "refseqProtein": "NP_006261.1",
      "exons": [
        {
          "start": 49635292,
          "end": 49635660
        },
        {
          "start": 49635734,
          "end": 49635852
        },
        {
          "start": 49636619,
          "end": 49636727
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        {
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        {
          "start": 49637043,
          "end": 49637130
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        {
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      ],
      "cds": {
        "start": 49635576,
        "end": 49640098
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "19",
      "start": 50138549,
      "end": 50143458,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 50137717,
      "genes": [
        {
          "symbol": "PPFIA3",
          "ensemblId": "ENSG00000177380",
          "biotype": "protein_coding",
          "start": 49119401,
          "end": 49151027,
          "strand": "+",
          "slug": "ppfia3"
        },
        {
          "symbol": "HRC",
          "ensemblId": "ENSG00000130528",
          "biotype": "protein_coding",
          "start": 49151014,
          "end": 49155441,
          "strand": "-",
          "slug": "hrc"
        },
        {
          "symbol": "TRPM4",
          "ensemblId": "ENSG00000130529",
          "biotype": "protein_coding",
          "start": 49157737,
          "end": 49211841,
          "strand": "+",
          "slug": "trpm4"
        },
        {
          "symbol": "SLC6A16",
          "ensemblId": "ENSG00000063127",
          "biotype": "protein_coding",
          "start": 49289638,
          "end": 49325215,
          "strand": "-",
          "slug": "slc6a16"
        },
        {
          "symbol": "CD37",
          "ensemblId": "ENSG00000104894",
          "biotype": "protein_coding",
          "start": 49335171,
          "end": 49343335,
          "strand": "+",
          "slug": "cd37"
        },
        {
          "symbol": "TEAD2",
          "ensemblId": "ENSG00000074219",
          "biotype": "protein_coding",
          "start": 49340389,
          "end": 49362729,
          "strand": "-",
          "slug": "tead2"
        },
        {
          "symbol": "DKKL1",
          "ensemblId": "ENSG00000104901",
          "biotype": "protein_coding",
          "start": 49361783,
          "end": 49375120,
          "strand": "+",
          "slug": "dkkl1"
        },
        {
          "symbol": "KASH5",
          "ensemblId": "ENSG00000161609",
          "biotype": "protein_coding",
          "start": 49388219,
          "end": 49417990,
          "strand": "+",
          "slug": "kash5"
        },
        {
          "symbol": "PTH2",
          "ensemblId": "ENSG00000142538",
          "biotype": "protein_coding",
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          "end": 49423660,
          "strand": "-",
          "slug": "pth2"
        },
        {
          "symbol": "GFY",
          "ensemblId": "ENSG00000261949",
          "biotype": "protein_coding",
          "start": 49423749,
          "end": 49428987,
          "strand": "+",
          "slug": "gfy"
        },
        {
          "symbol": "SLC17A7",
          "ensemblId": "ENSG00000104888",
          "biotype": "protein_coding",
          "start": 49429399,
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          "strand": "-",
          "slug": "slc17a7"
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        {
          "symbol": "PIH1D1",
          "ensemblId": "ENSG00000104872",
          "biotype": "protein_coding",
          "start": 49446291,
          "end": 49453537,
          "strand": "-",
          "slug": "pih1d1"
        },
        {
          "symbol": "ALDH16A1",
          "ensemblId": "ENSG00000161618",
          "biotype": "protein_coding",
          "start": 49453146,
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          "strand": "+",
          "slug": "aldh16a1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000269469",
          "biotype": "protein_coding",
          "start": 49462752,
          "end": 49486231,
          "strand": "+"
        },
        {
          "symbol": "FLT3LG",
          "ensemblId": "ENSG00000090554",
          "biotype": "protein_coding",
          "start": 49474150,
          "end": 49486233,
          "strand": "+",
          "slug": "flt3lg"
        },
        {
          "symbol": "RPL13A",
          "ensemblId": "ENSG00000142541",
          "biotype": "protein_coding",
          "start": 49487510,
          "end": 49493057,
          "strand": "+",
          "slug": "rpl13a"
        },
        {
          "symbol": "RPS11",
          "ensemblId": "ENSG00000142534",
          "biotype": "protein_coding",
          "start": 49496233,
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          "strand": "+",
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        {
          "symbol": "FCGRT",
          "ensemblId": "ENSG00000104870",
          "biotype": "protein_coding",
          "start": 49506806,
          "end": 49526917,
          "strand": "+",
          "slug": "fcgrt"
        },
        {
          "symbol": "RCN3",
          "ensemblId": "ENSG00000142552",
          "biotype": "protein_coding",
          "start": 49526534,
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          "strand": "+",
          "slug": "rcn3"
        },
        {
          "symbol": "NOSIP",
          "ensemblId": "ENSG00000142546",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
          "symbol": "PRRG2",
          "ensemblId": "ENSG00000126460",
          "biotype": "protein_coding",
          "start": 49580646,
          "end": 49591004,
          "strand": "+",
          "slug": "prrg2"
        },
        {
          "symbol": "PRR12",
          "ensemblId": "ENSG00000126464",
          "biotype": "protein_coding",
          "start": 49591108,
          "end": 49626439,
          "strand": "+",
          "slug": "prr12"
        },
        {
          "symbol": "SCAF1",
          "ensemblId": "ENSG00000126461",
          "biotype": "protein_coding",
          "start": 49640488,
          "end": 49658649,
          "strand": "+",
          "slug": "scaf1"
        },
        {
          "symbol": "IRF3",
          "ensemblId": "ENSG00000126456",
          "biotype": "protein_coding",
          "start": 49659569,
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          "strand": "-",
          "slug": "irf3"
        },
        {
          "symbol": "BCL2L12",
          "ensemblId": "ENSG00000126453",
          "biotype": "protein_coding",
          "start": 49664622,
          "end": 49673917,
          "strand": "+",
          "slug": "bcl2l12"
        },
        {
          "symbol": "PRMT1",
          "ensemblId": "ENSG00000126457",
          "biotype": "protein_coding",
          "start": 49675786,
          "end": 49689029,
          "strand": "+",
          "slug": "prmt1"
        },
        {
          "symbol": "ADM5",
          "ensemblId": "ENSG00000224420",
          "biotype": "protein_coding",
          "start": 49688953,
          "end": 49690575,
          "strand": "+",
          "slug": "adm5"
        },
        {
          "symbol": "CPT1C",
          "ensemblId": "ENSG00000169169",
          "biotype": "protein_coding",
          "start": 49690898,
          "end": 49713733,
          "strand": "+",
          "slug": "cpt1c"
        },
        {
          "symbol": "TSKS",
          "ensemblId": "ENSG00000126467",
          "biotype": "protein_coding",
          "start": 49739753,
          "end": 49763329,
          "strand": "-",
          "slug": "tsks"
        },
        {
          "symbol": "AP2A1",
          "ensemblId": "ENSG00000196961",
          "biotype": "protein_coding",
          "start": 49766912,
          "end": 49807114,
          "strand": "+",
          "slug": "ap2a1"
        },
        {
          "symbol": "FUZ",
          "ensemblId": "ENSG00000010361",
          "biotype": "protein_coding",
          "start": 49806866,
          "end": 49817376,
          "strand": "-",
          "slug": "fuz"
        },
        {
          "symbol": "MED25",
          "ensemblId": "ENSG00000104973",
          "biotype": "protein_coding",
          "start": 49818269,
          "end": 49840384,
          "strand": "+",
          "slug": "med25"
        },
        {
          "symbol": "PTOV1",
          "ensemblId": "ENSG00000104960",
          "biotype": "protein_coding",
          "start": 49850735,
          "end": 49860744,
          "strand": "+",
          "slug": "ptov1"
        },
        {
          "symbol": "PNKP",
          "ensemblId": "ENSG00000039650",
          "biotype": "protein_coding",
          "start": 49859882,
          "end": 49878351,
          "strand": "-",
          "slug": "pnkp"
        },
        {
          "symbol": "AKT1S1",
          "ensemblId": "ENSG00000204673",
          "biotype": "protein_coding",
          "start": 49869023,
          "end": 49879470,
          "strand": "-",
          "slug": "akt1s1"
        },
        {
          "symbol": "TBC1D17",
          "ensemblId": "ENSG00000104946",
          "biotype": "protein_coding",
          "start": 49877501,
          "end": 49888751,
          "strand": "+",
          "slug": "tbc1d17"
        },
        {
          "symbol": "IL4I1",
          "ensemblId": "ENSG00000104951",
          "biotype": "protein_coding",
          "start": 49889654,
          "end": 49929926,
          "strand": "-",
          "slug": "il4i1"
        },
        {
          "symbol": "NUP62",
          "ensemblId": "ENSG00000213024",
          "biotype": "protein_coding",
          "start": 49906825,
          "end": 49929926,
          "strand": "-",
          "slug": "nup62"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000269179",
          "biotype": "protein_coding",
          "start": 49909501,
          "end": 49958391,
          "strand": "-"
        },
        {
          "symbol": "ATF5",
          "ensemblId": "ENSG00000169136",
          "biotype": "protein_coding",
          "start": 49923910,
          "end": 49933935,
          "strand": "+",
          "slug": "atf5"
        },
        {
          "symbol": "SIGLEC11",
          "ensemblId": "ENSG00000161640",
          "biotype": "protein_coding",
          "start": 49948910,
          "end": 49961172,
          "strand": "-",
          "slug": "siglec11"
        },
        {
          "symbol": "SIGLEC16",
          "ensemblId": "ENSG00000161643",
          "biotype": "protein_coding",
          "start": 49969600,
          "end": 49975819,
          "strand": "+",
          "slug": "siglec16"
        },
        {
          "symbol": "VRK3",
          "ensemblId": "ENSG00000105053",
          "biotype": "protein_coding",
          "start": 49974537,
          "end": 50025946,
          "strand": "-",
          "slug": "vrk3"
        },
        {
          "symbol": "ZNF473",
          "ensemblId": "ENSG00000142528",
          "biotype": "protein_coding",
          "start": 50025714,
          "end": 50053414,
          "strand": "+",
          "slug": "znf473"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "noonan-syndrome",
        "name": "Noonan-i sündroom",
        "diseases": [
          {
            "mondoId": "MONDO:0020297",
            "name": "Noonani sündroom ja Noonanilaadsed sündroomid",
            "genes": 21,
            "inheritance": null,
            "description": "RAS-signaaliraja haiguste rühm, sealhulgas Noonani, Costello, kardiofaciokutaanne ja Legiuse sündroom; esineb erinevaid südamedefekte, lühikest kasvu ja iseloomulikke näojooni.",
            "management": "Selle teadmine toetab südame, kasvu ja arengu hindamist.",
            "evidence": {
              "gencc": [
                "G2P"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/et/conditions/noonan-syndrome"
      },
      {
        "slug": "hypertrophic-cardiomyopathy",
        "name": "Hüpertroofiline kardiomüopaatia",
        "diseases": [
          {
            "mondoId": "MONDO:0005045",
            "name": "Hüpertroofiline kardiomüopaatia",
            "genes": 62,
            "inheritance": "autosomal-dominant",
            "description": "Seisund, mille puhul müokard on hüpertrofeerunud ilma ilmse põhjuseta. Hüpertroofia on üldiselt asümmeetriline ja võib olla seotud vatsakese väljavoolutrakti obstruktsiooniga.",
            "management": "Beeta-blokaatorid, mittedihüdropüridiinsed kaltsiumikanalite blokaatorid, füüsilise koormuse piiramine, geneetiline nõustamine",
            "evidence": {
              "gencc": [
                "G2P"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/et/conditions/hypertrophic-cardiomyopathy"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-cardiovascular-system-morphology",
        "name": "Abnormal cardiovascular system morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-cardiovascular-system-morphology"
      },
      {
        "slug": "abnormal-ekg",
        "name": "Abnormal EKG",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-ekg"
      },
      {
        "slug": "abnormal-dermatoglyphics",
        "name": "Abnormal fingerprints",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-dermatoglyphics"
      },
      {
        "slug": "abnormal-hair-quantity",
        "name": "Abnormal hair quantity",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-hair-quantity"
      },
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arrhythmia"
      },
      {
        "slug": "abnormal-platelet-function",
        "name": "Abnormal platelet function",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-platelet-function"
      },
      {
        "slug": "abnormal-pulmonary-valve-morphology",
        "name": "Abnormal pulmonary valve morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-pulmonary-valve-morphology"
      },
      {
        "slug": "abnormal-speech-pattern",
        "name": "Abnormal speech pattern",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-speech-pattern"
      },
      {
        "slug": "abnormality-of-coagulation",
        "name": "Abnormality of coagulation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-coagulation"
      },
      {
        "slug": "abnormality-of-the-lymphatic-system",
        "name": "Abnormality of the lymphatic system",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-lymphatic-system"
      },
      {
        "slug": "abnormality-of-the-genital-system",
        "name": "Abnormality of the reproductive system",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genital-system"
      },
      {
        "slug": "abnormality-of-the-spleen",
        "name": "Abnormality of the spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-spleen"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-abdominal-wall-musculature",
        "name": "Absent/small abdominal wall muscles",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-abdominal-wall-musculature"
      },
      {
        "slug": "atrial-septal-defect",
        "name": "An opening in the wall separating the top two chambers of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atrial-septal-defect"
      },
      {
        "slug": "aplasia-of-the-semicircular-canal",
        "name": "Aplasia of the semicircular canal",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aplasia-of-the-semicircular-canal"
      },
      {
        "slug": "melanocytic-nevus",
        "name": "Beauty mark",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/melanocytic-nevus"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "blue-irides",
        "name": "Blue eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/blue-irides"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "proptosis",
        "name": "Bulging eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/proptosis"
      },
      {
        "slug": "coarse-hair",
        "name": "Coarse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/coarse-hair"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "cystic-hygroma",
        "name": "Cystic hygroma",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cystic-hygroma"
      },
      {
        "slug": "delayed-skeletal-maturation",
        "name": "Delayed bone maturation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-skeletal-maturation"
      },
      {
        "slug": "delayed-menarche",
        "name": "Delayed start of first period",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system",
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/delayed-menarche"
      },
      {
        "slug": "dysarthria",
        "name": "Difficulty articulating speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/dysarthria"
      },
      {
        "slug": "dilatation-of-the-renal-pelvis",
        "name": "Dilatation of the renal pelvis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dilatation-of-the-renal-pelvis"
      },
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      },
      {
        "slug": "downslanted-palpebral-fissures",
        "name": "Downward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/downslanted-palpebral-fissures"
      },
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "posteriorly-rotated-ears",
        "name": "Ears rotated toward back of head",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/posteriorly-rotated-ears"
      },
      {
        "slug": "hypertrophic-cardiomyopathy",
        "name": "Enlarged and thickened heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertrophic-cardiomyopathy"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "feeding-difficulties-in-infancy",
        "name": "Feeding difficulties in infancy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/feeding-difficulties-in-infancy"
      },
      {
        "slug": "thick-lower-lip-vermilion",
        "name": "Full lower lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/thick-lower-lip-vermilion"
      },
      {
        "slug": "pectus-excavatum",
        "name": "Funnel chest",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pectus-excavatum"
      },
      {
        "slug": "radioulnar-synostosis",
        "name": "Fused forearm bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/radioulnar-synostosis"
      },
      {
        "slug": "postnatal-growth-retardation",
        "name": "Growth delay as children",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/postnatal-growth-retardation"
      },
      {
        "slug": "high-forehead",
        "name": "High forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/high-forehead"
      },
      {
        "slug": "high-palate",
        "name": "High palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/high-palate"
      },
      {
        "slug": "hypogonadotropic-hypogonadism",
        "name": "Hypogonadotropic hypogonadism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypogonadotropic-hypogonadism"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "juvenile-myelomonocytic-leukemia",
        "name": "Juvenile myelomonocytic leukemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/juvenile-myelomonocytic-leukemia"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "low-posterior-hairline",
        "name": "Low hairline at back of neck",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/low-posterior-hairline"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "midface-retrusion",
        "name": "Midface retrusion",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/midface-retrusion"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "coarctation-of-aorta",
        "name": "Narrowing of aorta",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/coarctation-of-aorta"
      },
      {
        "slug": "pulmonary-artery-stenosis",
        "name": "Narrowing of lung artery",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pulmonary-artery-stenosis"
      },
      {
        "slug": "neurodevelopmental-delay",
        "name": "Neurodevelopmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neurodevelopmental-delay"
      },
      {
        "slug": "osteopenia",
        "name": "Osteopenia",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/osteopenia"
      },
      {
        "slug": "patent-ductus-arteriosus",
        "name": "Patent ductus arteriosus",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus"
      },
      {
        "slug": "pectus-carinatum",
        "name": "Pigeon chest",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pectus-carinatum"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "specific-learning-disability",
        "name": "Specific learning disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/specific-learning-disability"
      },
      {
        "slug": "lymphedema",
        "name": "Swelling caused by excess lymph fluid under skin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lymphedema"
      },
      {
        "slug": "thickened-helices",
        "name": "Thickened helices",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/thickened-helices"
      },
      {
        "slug": "thickened-nuchal-skin-fold",
        "name": "Thickened skin folds of neck",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/thickened-nuchal-skin-fold"
      },
      {
        "slug": "triangular-face",
        "name": "Triangular face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/triangular-face"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "webbed-neck",
        "name": "Webbed neck",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/webbed-neck"
      },
      {
        "slug": "enlarged-thorax",
        "name": "Wide rib cage",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/enlarged-thorax"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypertelorism"
      },
      {
        "slug": "wide-intermamillary-distance",
        "name": "Wide-spaced nipples",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/wide-intermamillary-distance"
      }
    ],
    "related": [
      {
        "slug": "braf",
        "symbol": "BRAF",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/braf"
      },
      {
        "slug": "erf",
        "symbol": "ERF",
        "name": "ETS2 repressor factor",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/erf"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "name": "HRas proto-oncogene, GTPase",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/hras"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "name": "KRas proto-oncogene, GTPase",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/kras"
      },
      {
        "slug": "lztr1",
        "symbol": "LZTR1",
        "name": "leucine zipper like post translational regulator 1",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/lztr1"
      },
      {
        "slug": "map2k1",
        "symbol": "MAP2K1",
        "name": "mitogen-activated protein kinase kinase 1",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/map2k1"
      },
      {
        "slug": "map2k2",
        "symbol": "MAP2K2",
        "name": "mitogen-activated protein kinase kinase 2",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/map2k2"
      },
      {
        "slug": "mapk1",
        "symbol": "MAPK1",
        "name": "mitogen-activated protein kinase 1",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/mapk1"
      },
      {
        "slug": "mras",
        "symbol": "MRAS",
        "name": "muscle RAS oncogene homolog",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/mras"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "name": "NRAS proto-oncogene, GTPase",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/nras"
      },
      {
        "slug": "ppp1cb",
        "symbol": "PPP1CB",
        "name": "protein phosphatase 1 catalytic subunit beta",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/ppp1cb"
      },
      {
        "slug": "ptpn11",
        "symbol": "PTPN11",
        "name": "protein tyrosine phosphatase non-receptor type 11",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/ptpn11"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}