{
  "url": "https://dantelabs.com/et/genes/plag1",
  "gene": {
    "slug": "plag1",
    "symbol": "PLAG1",
    "name": "PLAG1 zinc finger",
    "hgnc": "HGNC:9045",
    "summary": null,
    "location": "8q12.1",
    "locusType": "gene with protein product",
    "aliases": [
      "ZNF912"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000181690",
    "entrezId": 5324,
    "omim": [
      "603026"
    ],
    "uniprot": [
      "Q6DJT9"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
      "start": 56160909,
      "end": 56211273,
      "strand": "-",
      "ensemblTranscript": "ENST00000316981.8",
      "refseqTranscript": "NM_002655.3",
      "ensemblProtein": "ENSP00000325546.3",
      "refseqProtein": "NP_002646.2",
      "exons": [
        {
          "start": 56160909,
          "end": 56167503
        },
        {
          "start": 56168028,
          "end": 56168386
        },
        {
          "start": 56171091,
          "end": 56171189
        },
        {
          "start": 56179409,
          "end": 56179513
        },
        {
          "start": 56211121,
          "end": 56211273
        }
      ],
      "cds": {
        "start": 56166243,
        "end": 56168269
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
      "start": 57073463,
      "end": 57123883,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 55686091,
      "end": 56686090,
      "genes": [
        {
          "symbol": "TMEM68",
          "ensemblId": "ENSG00000167904",
          "biotype": "protein_coding",
          "start": 55696424,
          "end": 55773417,
          "strand": "-",
          "slug": "tmem68"
        },
        {
          "symbol": "TGS1",
          "ensemblId": "ENSG00000137574",
          "biotype": "protein_coding",
          "start": 55773065,
          "end": 55827247,
          "strand": "+",
          "slug": "tgs1"
        },
        {
          "symbol": "LYN",
          "ensemblId": "ENSG00000254087",
          "biotype": "protein_coding",
          "start": 55879797,
          "end": 56014169,
          "strand": "+",
          "slug": "lyn"
        },
        {
          "symbol": "RPS20",
          "ensemblId": "ENSG00000008988",
          "biotype": "protein_coding",
          "start": 56020034,
          "end": 56074575,
          "strand": "-",
          "slug": "rps20"
        },
        {
          "symbol": "MOS",
          "ensemblId": "ENSG00000172680",
          "biotype": "protein_coding",
          "start": 56112942,
          "end": 56113982,
          "strand": "-",
          "slug": "mos"
        },
        {
          "symbol": "CHCHD7",
          "ensemblId": "ENSG00000170791",
          "biotype": "protein_coding",
          "start": 56211560,
          "end": 56218809,
          "strand": "+",
          "slug": "chchd7"
        },
        {
          "symbol": "SDR16C5",
          "ensemblId": "ENSG00000170786",
          "biotype": "protein_coding",
          "start": 56300005,
          "end": 56320776,
          "strand": "-",
          "slug": "sdr16c5"
        },
        {
          "symbol": "PENK",
          "ensemblId": "ENSG00000181195",
          "biotype": "protein_coding",
          "start": 56436674,
          "end": 56448048,
          "strand": "-",
          "slug": "penk"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "imprinting-disorders",
        "name": "Imprintingu häired: Prader-Willi, Silver-Russell ja Beckwith-Wiedemanni sündroom",
        "diseases": [
          {
            "mondoId": "MONDO:0008394",
            "name": "Silver-Russelli sündroom",
            "genes": 3,
            "inheritance": null,
            "description": "Kasvuhäire, mis on tavaliselt põhjustatud metülatsiooni muutustest 11p15 piirkonnas võiema-poolsest 7. kromosoomi uniparentaalsest disoomiast ning mõnikord variantidest IGF2, PLAG1, HMGA2 või CDKN1C geenis. See põhjustab kasvu piiratust nii enne sündi kui pärast seda ning keha asümmeetriat.",
            "management": "Diagnoos suunab toitumise, veresuhkru ja kasvu juhtimist.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/et/conditions/imprinting-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-scrotum-morphology",
        "name": "Abnormal scrotum morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-scrotum-morphology"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "systems": [],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "asthma",
        "name": "Asthma",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asthma"
      },
      {
        "slug": "attention-deficit-hyperactivity-disorder",
        "name": "Attention deficit",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/attention-deficit-hyperactivity-disorder"
      },
      {
        "slug": "birth-length-less-than-3rd-percentile",
        "name": "Birth length less than 3rd percentile",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/birth-length-less-than-3rd-percentile"
      },
      {
        "slug": "cafe-au-lait-spot",
        "name": "Birthmark",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cafe-au-lait-spot"
      },
      {
        "slug": "salivary-gland-neoplasm",
        "name": "Cancer of salivary gland",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/salivary-gland-neoplasm"
      },
      {
        "slug": "ectrodactyly",
        "name": "Cleft hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ectrodactyly"
      },
      {
        "slug": "bifid-scrotum",
        "name": "Cleft of scrotum",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bifid-scrotum"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cleft-palate"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "decreased-body-weight",
        "name": "Decreased body weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-body-weight"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "feeding-difficulties-in-infancy",
        "name": "Feeding difficulties in infancy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/feeding-difficulties-in-infancy"
      },
      {
        "slug": "frontal-bossing",
        "name": "Frontal bossing",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/frontal-bossing"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "postnatal-growth-retardation",
        "name": "Growth delay as children",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/postnatal-growth-retardation"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "inguinal-hernia",
        "name": "Inguinal hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/inguinal-hernia"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "hypoglycemia",
        "name": "Low blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoglycemia"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "low-set-ears",
        "name": "Low-set ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/low-set-ears"
      },
      {
        "slug": "microphallus",
        "name": "Microphallus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/microphallus"
      },
      {
        "slug": "polydactyly",
        "name": "More than five fingers or toes on hands or feet",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/polydactyly"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "dysmenorrhea",
        "name": "Painful menstruation",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dysmenorrhea"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "prominent-forehead",
        "name": "Prominent forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/prominent-forehead"
      },
      {
        "slug": "relative-macrocephaly",
        "name": "Relatively large head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/relative-macrocephaly"
      },
      {
        "slug": "short-5th-finger",
        "name": "Short 5th finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-5th-finger"
      },
      {
        "slug": "hypoplastic-fingernail",
        "name": "Small fingernail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplastic-fingernail"
      },
      {
        "slug": "small-for-gestational-age",
        "name": "Small for gestational age",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/small-for-gestational-age"
      },
      {
        "slug": "small-placenta",
        "name": "Small placenta",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/small-placenta"
      },
      {
        "slug": "triangular-face",
        "name": "Triangular face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/triangular-face"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "asymmetric-growth",
        "name": "Uneven or disproportionate growth of one body part compared to another",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asymmetric-growth"
      },
      {
        "slug": "syndactyly",
        "name": "Webbed fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/syndactyly"
      }
    ],
    "related": [
      {
        "slug": "hmga2",
        "symbol": "HMGA2",
        "name": "high mobility group AT-hook 2",
        "shared": 1,
        "url": "https://dantelabs.com/et/genes/hmga2"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "name": "insulin like growth factor 2",
        "shared": 1,
        "url": "https://dantelabs.com/et/genes/igf2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}