{
  "url": "https://dantelabs.com/et/genes/nfkb2",
  "gene": {
    "slug": "nfkb2",
    "symbol": "NFKB2",
    "name": "nuclear factor kappa B subunit 2",
    "hgnc": "HGNC:7795",
    "summary": null,
    "location": "10q24.32",
    "locusType": "gene with protein product",
    "aliases": [
      "LYT-10",
      "p52",
      "p105",
      "NF-kB2",
      "p49/p100"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000077150",
    "entrezId": 4791,
    "omim": [
      "164012"
    ],
    "uniprot": [
      "Q00653"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 102395705,
      "end": 102402524,
      "strand": "+",
      "ensemblTranscript": "ENST00000661543.1",
      "refseqTranscript": "NM_001322934.2",
      "ensemblProtein": "ENSP00000499294.1",
      "refseqProtein": "NP_001309863.1",
      "exons": [
        {
          "start": 102395705,
          "end": 102395796
        },
        {
          "start": 102395888,
          "end": 102395980
        },
        {
          "start": 102396253,
          "end": 102396334
        },
        {
          "start": 102396449,
          "end": 102396489
        },
        {
          "start": 102396725,
          "end": 102396823
        },
        {
          "start": 102396904,
          "end": 102397055
        },
        {
          "start": 102397302,
          "end": 102397408
        },
        {
          "start": 102397527,
          "end": 102397685
        },
        {
          "start": 102397981,
          "end": 102398085
        },
        {
          "start": 102398212,
          "end": 102398297
        },
        {
          "start": 102398385,
          "end": 102398523
        },
        {
          "start": 102398739,
          "end": 102398864
        },
        {
          "start": 102399288,
          "end": 102399497
        },
        {
          "start": 102399577,
          "end": 102399718
        },
        {
          "start": 102400080,
          "end": 102400194
        },
        {
          "start": 102400278,
          "end": 102400491
        },
        {
          "start": 102400655,
          "end": 102400824
        },
        {
          "start": 102400947,
          "end": 102401049
        },
        {
          "start": 102401180,
          "end": 102401331
        },
        {
          "start": 102401449,
          "end": 102401518
        },
        {
          "start": 102401745,
          "end": 102401917
        },
        {
          "start": 102402048,
          "end": 102402159
        },
        {
          "start": 102402252,
          "end": 102402524
        }
      ],
      "cds": {
        "start": 102395960,
        "end": 102402376
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 104153867,
      "end": 104162281,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 101899115,
      "end": 102899114,
      "genes": [
        {
          "symbol": "ARMH3",
          "ensemblId": "ENSG00000120029",
          "biotype": "protein_coding",
          "start": 101845599,
          "end": 102056262,
          "strand": "-",
          "slug": "armh3"
        },
        {
          "symbol": "HPS6",
          "ensemblId": "ENSG00000166189",
          "biotype": "protein_coding",
          "start": 102065349,
          "end": 102068036,
          "strand": "+",
          "slug": "hps6"
        },
        {
          "symbol": "LDB1",
          "ensemblId": "ENSG00000198728",
          "biotype": "protein_coding",
          "start": 102106489,
          "end": 102120451,
          "strand": "-",
          "slug": "ldb1"
        },
        {
          "symbol": "PPRC1",
          "ensemblId": "ENSG00000148840",
          "biotype": "protein_coding",
          "start": 102132994,
          "end": 102150333,
          "strand": "+",
          "slug": "pprc1"
        },
        {
          "symbol": "NOLC1",
          "ensemblId": "ENSG00000166197",
          "biotype": "protein_coding",
          "start": 102152170,
          "end": 102163875,
          "strand": "+",
          "slug": "nolc1"
        },
        {
          "symbol": "ELOVL3",
          "ensemblId": "ENSG00000119915",
          "biotype": "protein_coding",
          "start": 102226294,
          "end": 102229589,
          "strand": "+",
          "slug": "elovl3"
        },
        {
          "symbol": "PITX3",
          "ensemblId": "ENSG00000107859",
          "biotype": "protein_coding",
          "start": 102229754,
          "end": 102241512,
          "strand": "-",
          "slug": "pitx3"
        },
        {
          "symbol": "GBF1",
          "ensemblId": "ENSG00000107862",
          "biotype": "protein_coding",
          "start": 102245371,
          "end": 102382899,
          "strand": "+",
          "slug": "gbf1"
        },
        {
          "symbol": "PSD",
          "ensemblId": "ENSG00000059915",
          "biotype": "protein_coding",
          "start": 102402614,
          "end": 102421539,
          "strand": "-",
          "slug": "psd"
        },
        {
          "symbol": "FBXL15",
          "ensemblId": "ENSG00000107872",
          "biotype": "protein_coding",
          "start": 102408835,
          "end": 102423142,
          "strand": "+",
          "slug": "fbxl15"
        },
        {
          "symbol": "CUEDC2",
          "ensemblId": "ENSG00000107874",
          "biotype": "protein_coding",
          "start": 102423239,
          "end": 102432718,
          "strand": "-",
          "slug": "cuedc2"
        },
        {
          "symbol": "C10orf95",
          "ensemblId": "ENSG00000120055",
          "biotype": "protein_coding",
          "start": 102449619,
          "end": 102451548,
          "strand": "-",
          "slug": "c10orf95"
        },
        {
          "symbol": "SLC68A1",
          "ensemblId": "ENSG00000138111",
          "biotype": "protein_coding",
          "start": 102461363,
          "end": 102477046,
          "strand": "+",
          "slug": "slc68a1"
        },
        {
          "symbol": "ACTR1A",
          "ensemblId": "ENSG00000138107",
          "biotype": "protein_coding",
          "start": 102461881,
          "end": 102502744,
          "strand": "-",
          "slug": "actr1a"
        },
        {
          "symbol": "SUFU",
          "ensemblId": "ENSG00000107882",
          "biotype": "protein_coding",
          "start": 102503952,
          "end": 102633535,
          "strand": "+",
          "slug": "sufu"
        },
        {
          "symbol": "TRIM8",
          "ensemblId": "ENSG00000171206",
          "biotype": "protein_coding",
          "start": 102642394,
          "end": 102662789,
          "strand": "+",
          "slug": "trim8"
        },
        {
          "symbol": "ARL3",
          "ensemblId": "ENSG00000138175",
          "biotype": "protein_coding",
          "start": 102673731,
          "end": 102714527,
          "strand": "-",
          "slug": "arl3"
        },
        {
          "symbol": "SFXN2",
          "ensemblId": "ENSG00000156398",
          "biotype": "protein_coding",
          "start": 102714476,
          "end": 102743492,
          "strand": "+",
          "slug": "sfxn2"
        },
        {
          "symbol": "WBP1L",
          "ensemblId": "ENSG00000166272",
          "biotype": "protein_coding",
          "start": 102743923,
          "end": 102834613,
          "strand": "+",
          "slug": "wbp1l"
        },
        {
          "symbol": "CYP17A1",
          "ensemblId": "ENSG00000148795",
          "biotype": "protein_coding",
          "start": 102830460,
          "end": 102837506,
          "strand": "-",
          "slug": "cyp17a1"
        },
        {
          "symbol": "BORCS7",
          "ensemblId": "ENSG00000166275",
          "biotype": "protein_coding",
          "start": 102854224,
          "end": 102864979,
          "strand": "+",
          "slug": "borcs7"
        },
        {
          "symbol": "BORCS7-ASMT",
          "ensemblId": "ENSG00000270316",
          "biotype": "protein_coding",
          "start": 102854272,
          "end": 102901899,
          "strand": "+",
          "slug": "borcs7-asmt"
        },
        {
          "symbol": "AS3MT",
          "ensemblId": "ENSG00000214435",
          "biotype": "protein_coding",
          "start": 102869296,
          "end": 102901911,
          "strand": "+",
          "slug": "as3mt"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "common-variable-immunodeficiency",
        "name": "Tavapärane muutlik immuunpuudulikkus (monogeenne CVID)",
        "diseases": [
          {
            "mondoId": "MONDO:0015517",
            "name": "Tavapärane muutlik immuunpuudulikkus",
            "genes": 10,
            "inheritance": null,
            "description": "Madal IgG koos madala IgA ja/või IgM-iga ning nõrk vastus vaktsineerimisele; üksikgeensed vormid hõlmavad geene NFKB1, NFKB2, ICOS, CD19, CD81, CR2, IKZF1, IRF2BP2, SEC61A1 ja TNFRSF13B (TACI).",
            "management": "Standardne ravi hõlmab immunoglobuliini asendusravi ja infektsioonide varajast ravi; geneetiline põhjus võib aidata suunata jälgimist autoimmuunsuse, lümfoomi ja kopahaiguste suhtes ning mõned vormid (näiteks LRBA-puudulikkus) reageerivad sihtravile.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/et/conditions/common-variable-immunodeficiency"
      },
      {
        "slug": "immunodeficiency-disease",
        "name": "Ostali pärilikud immuunpuudulikkused",
        "diseases": [
          {
            "mondoId": "MONDO:0003778",
            "name": "Pärilik immuunpuudulikkus",
            "genes": 114,
            "inheritance": null,
            "description": "Pärilikud immuunsüsteemi häired, mis on põhjustatud üksikute geenide muutustest ning mõjutavad seda, kuidas organism infektsioonidega võitleb või põletikku reguleerib.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": true
          },
          {
            "mondoId": "MONDO:0021094",
            "name": "Immuunpuudulikkushaigus",
            "genes": 170,
            "inheritance": null,
            "description": "Haigus, mille korral on rakulise või humoraalse immuunsuse mehhanismid puudulikud või defektsed.",
            "management": "HSCT raske kombineeritud immuunpuudulikkuse (SCID) ja muude raskete PID-ide korral; immunoglobuliini asendusravi (IVIG/SCIG) antikehade puudulikkuse korral; leniolisib (Joenja, FDA 2023) APDS-i korral; geenravi ADA-SCID-i korral; abatatsept CTLA4/LRBA puudulikkuse korral; profülaktilised antibiootikumid; G-CSF CGD korral",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/et/conditions/immunodeficiency-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-lymphocyte-morphology",
        "name": "Abnormal lymphocyte morphology",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-lymphocyte-morphology"
      },
      {
        "slug": "abnormal-periungual-morphology",
        "name": "Abnormal periungual morphology",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-periungual-morphology"
      },
      {
        "slug": "abnormal-response-to-acth-stimulation-test",
        "name": "Abnormal response to ACTH stimulation test",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-response-to-acth-stimulation-test"
      },
      {
        "slug": "abnormal-size-of-pituitary-gland",
        "name": "Abnormal size of pituitary gland",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-size-of-pituitary-gland"
      },
      {
        "slug": "adrenocorticotropin-deficient-adrenal-insufficiency",
        "name": "Adrenocorticotropin deficient adrenal insufficiency",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/adrenocorticotropin-deficient-adrenal-insufficiency"
      },
      {
        "slug": "alopecia-totalis",
        "name": "Alopecia totalis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/alopecia-totalis"
      },
      {
        "slug": "anti-thyroglobulin-antibody-positivity",
        "name": "Anti-thyroglobulin antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anti-thyroglobulin-antibody-positivity"
      },
      {
        "slug": "anti-thyroid-peroxidase-antibody-positivity",
        "name": "Anti-thyroid peroxidase antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anti-thyroid-peroxidase-antibody-positivity"
      },
      {
        "slug": "asthma",
        "name": "Asthma",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/asthma"
      },
      {
        "slug": "autoimmune-antibody-positivity",
        "name": "Autoimmune antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/autoimmune-antibody-positivity"
      },
      {
        "slug": "autoimmune-thrombocytopenia",
        "name": "Autoimmune thrombocytopenia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/autoimmune-thrombocytopenia"
      },
      {
        "slug": "vitiligo",
        "name": "Blotchy loss of skin color",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/vitiligo"
      },
      {
        "slug": "generalized-non-motor-absence-seizure",
        "name": "Brief seizures with staring spells",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/generalized-non-motor-absence-seizure"
      },
      {
        "slug": "central-adrenal-insufficiency",
        "name": "Central adrenal insufficiency",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/central-adrenal-insufficiency"
      },
      {
        "slug": "chiari-type-i-malformation",
        "name": "Chiari type I malformation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chiari-type-i-malformation"
      },
      {
        "slug": "hypoglycemic-coma",
        "name": "Coma caused by low blood sugar",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypoglycemic-coma"
      },
      {
        "slug": "combined-immunodeficiency",
        "name": "Combined immunodeficiency",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/combined-immunodeficiency"
      },
      {
        "slug": "decreased-circulating-acth-concentration",
        "name": "Decreased circulating ACTH concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-acth-concentration"
      },
      {
        "slug": "decreased-circulating-androgen-concentration",
        "name": "Decreased circulating androgen concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-circulating-androgen-concentration"
      },
      {
        "slug": "decreased-circulating-immunoglobulin-concentration",
        "name": "Decreased circulating antibody level",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-immunoglobulin-concentration"
      },
      {
        "slug": "decreased-circulating-iga-concentration",
        "name": "Decreased circulating IgA concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-iga-concentration"
      },
      {
        "slug": "decreased-circulating-igg-concentration",
        "name": "Decreased circulating IgG concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-igg-concentration"
      },
      {
        "slug": "decreased-circulating-igm-concentration",
        "name": "Decreased circulating IgM concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-igm-concentration"
      },
      {
        "slug": "decreased-circulating-insulin-like-growth-factor-1-concentration",
        "name": "Decreased circulating insulin-like growth factor 1 concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-circulating-insulin-like-growth-factor-1-concentration"
      },
      {
        "slug": "decreased-response-to-growth-hormone-stimulation-test",
        "name": "Decreased response to growth hormone stimulation test",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-response-to-growth-hormone-stimulation-test"
      },
      {
        "slug": "diplopia",
        "name": "Double vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diplopia"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "frequent-giardia-lamblia-infestation",
        "name": "Frequent Giardia lamblia infestation",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/frequent-giardia-lamblia-infestation"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "hyperkalemia",
        "name": "Increased circulating potassium concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hyperkalemia"
      },
      {
        "slug": "sepsis",
        "name": "Infection in blood stream",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sepsis"
      },
      {
        "slug": "decreased-total-b-cell-count",
        "name": "Low B cell count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-total-b-cell-count"
      },
      {
        "slug": "decreased-circulating-cortisol-level",
        "name": "Low blood cortisol level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-cortisol-level"
      },
      {
        "slug": "hypotension",
        "name": "Low blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypotension"
      },
      {
        "slug": "hyponatremia",
        "name": "Low blood sodium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyponatremia"
      },
      {
        "slug": "hypoglycemia",
        "name": "Low blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hypoglycemia"
      },
      {
        "slug": "bronchiectasis",
        "name": "Permanent enlargement of the airways of the lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bronchiectasis"
      },
      {
        "slug": "nail-dystrophy",
        "name": "Poor nail formation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nail-dystrophy"
      },
      {
        "slug": "psoriasiform-dermatitis",
        "name": "Psoriasiform dermatitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/psoriasiform-dermatitis"
      },
      {
        "slug": "pyloric-stenosis",
        "name": "Pyloric stenosis",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pyloric-stenosis"
      },
      {
        "slug": "recurrent-bronchitis",
        "name": "Recurrent bronchitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-bronchitis"
      },
      {
        "slug": "recurrent-upper-respiratory-tract-infections",
        "name": "Recurrent colds",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-upper-respiratory-tract-infections"
      },
      {
        "slug": "recurrent-hypoglycemia",
        "name": "Recurrent low blood sugar levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-hypoglycemia"
      },
      {
        "slug": "recurrent-otitis-media",
        "name": "Recurrent middle ear infection",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-otitis-media"
      },
      {
        "slug": "recurrent-oral-herpes",
        "name": "Recurrent oral herpes",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-oral-herpes"
      },
      {
        "slug": "recurrent-pneumonia",
        "name": "Recurrent pneumonia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-pneumonia"
      },
      {
        "slug": "recurrent-sinusitis",
        "name": "Recurrent sinus disease",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-sinusitis"
      },
      {
        "slug": "recurrent-pharyngitis",
        "name": "Recurrent sore throat",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-pharyngitis"
      },
      {
        "slug": "recurrent-viral-infections",
        "name": "Recurrent viral infections",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-viral-infections"
      },
      {
        "slug": "recurrent-viral-upper-respiratory-tract-infections",
        "name": "Recurrent viral upper respiratory tract infections",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-viral-upper-respiratory-tract-infections"
      },
      {
        "slug": "thyroiditis",
        "name": "Thyroid gland inflammation",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/thyroiditis"
      },
      {
        "slug": "trachyonychia",
        "name": "Trachyonychia",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/trachyonychia"
      },
      {
        "slug": "unusual-fungal-nail-infection",
        "name": "Unusual fungal nail infection",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/unusual-fungal-nail-infection"
      }
    ],
    "related": [
      {
        "slug": "cd19",
        "symbol": "CD19",
        "name": "CD19 molecule",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/cd19"
      },
      {
        "slug": "cr2",
        "symbol": "CR2",
        "name": "complement C3d receptor 2",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/cr2"
      },
      {
        "slug": "icos",
        "symbol": "ICOS",
        "name": "inducible T cell costimulator",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/icos"
      },
      {
        "slug": "ikzf1",
        "symbol": "IKZF1",
        "name": "IKAROS family zinc finger 1",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/ikzf1"
      },
      {
        "slug": "irf2bp2",
        "symbol": "IRF2BP2",
        "name": "interferon regulatory factor 2 binding protein 2",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/irf2bp2"
      },
      {
        "slug": "lrba",
        "symbol": "LRBA",
        "name": "LPS responsive beige-like anchor protein",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/lrba"
      },
      {
        "slug": "nfkb1",
        "symbol": "NFKB1",
        "name": "nuclear factor kappa B subunit 1",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/nfkb1"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "name": "SEC61 translocon subunit alpha 1",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/sec61a1"
      },
      {
        "slug": "tnfrsf13b",
        "symbol": "TNFRSF13B",
        "name": "TNF receptor superfamily member 13B",
        "shared": 3,
        "url": "https://dantelabs.com/et/genes/tnfrsf13b"
      },
      {
        "slug": "aicda",
        "symbol": "AICDA",
        "name": "activation induced cytidine deaminase",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/aicda"
      },
      {
        "slug": "atp6ap1",
        "symbol": "ATP6AP1",
        "name": "ATPase H+ transporting accessory protein 1",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/atp6ap1"
      },
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "name": "BCL10 immune signaling adaptor",
        "shared": 2,
        "url": "https://dantelabs.com/et/genes/bcl10"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}