{
  "url": "https://dantelabs.com/et/genes/minpp1",
  "gene": {
    "slug": "minpp1",
    "symbol": "MINPP1",
    "name": "multiple inositol-polyphosphate phosphatase 1",
    "hgnc": "HGNC:7102",
    "summary": null,
    "location": "10q23.2",
    "locusType": "gene with protein product",
    "aliases": [
      "MIPP"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000107789",
    "entrezId": 9562,
    "omim": [
      "605391"
    ],
    "uniprot": [
      "Q9UNW1"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 87504893,
      "end": 87553461,
      "strand": "+",
      "ensemblTranscript": "ENST00000371996.9",
      "refseqTranscript": "NM_004897.5",
      "ensemblProtein": "ENSP00000361064.4",
      "refseqProtein": "NP_004888.2",
      "exons": [
        {
          "start": 87504893,
          "end": 87505552
        },
        {
          "start": 87508336,
          "end": 87508533
        },
        {
          "start": 87513124,
          "end": 87513221
        },
        {
          "start": 87521036,
          "end": 87521169
        },
        {
          "start": 87552082,
          "end": 87553461
        }
      ],
      "cds": {
        "start": 87504916,
        "end": 87552478
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 89264632,
      "end": 89313217,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 87029177,
      "end": 88029176,
      "genes": [
        {
          "symbol": "FAM25A",
          "ensemblId": "ENSG00000188100",
          "biotype": "protein_coding",
          "start": 87020238,
          "end": 87060609,
          "strand": "+",
          "slug": "fam25a"
        },
        {
          "symbol": "GLUD1",
          "ensemblId": "ENSG00000148672",
          "biotype": "protein_coding",
          "start": 87050202,
          "end": 87095405,
          "strand": "-",
          "slug": "glud1"
        },
        {
          "symbol": "SHLD2",
          "ensemblId": "ENSG00000122376",
          "biotype": "protein_coding",
          "start": 87094006,
          "end": 87191478,
          "strand": "+",
          "slug": "shld2"
        },
        {
          "symbol": "NUTM2A",
          "ensemblId": "ENSG00000184923",
          "biotype": "protein_coding",
          "start": 87225448,
          "end": 87236908,
          "strand": "+",
          "slug": "nutm2a"
        },
        {
          "symbol": "NUTM2D",
          "ensemblId": "ENSG00000214562",
          "biotype": "protein_coding",
          "start": 87357720,
          "end": 87370695,
          "strand": "+",
          "slug": "nutm2d"
        },
        {
          "symbol": "PAPSS2",
          "ensemblId": "ENSG00000198682",
          "biotype": "protein_coding",
          "start": 87659613,
          "end": 87747708,
          "strand": "+",
          "slug": "papss2"
        },
        {
          "symbol": "ATAD1",
          "ensemblId": "ENSG00000138138",
          "biotype": "protein_coding",
          "start": 87744644,
          "end": 87842355,
          "strand": "-",
          "slug": "atad1"
        },
        {
          "symbol": "KLLN",
          "ensemblId": "ENSG00000227268",
          "biotype": "protein_coding",
          "start": 87859158,
          "end": 87863533,
          "strand": "-",
          "slug": "klln"
        },
        {
          "symbol": "PTEN",
          "ensemblId": "ENSG00000171862",
          "biotype": "protein_coding",
          "start": 87862638,
          "end": 87971930,
          "strand": "+",
          "slug": "pten"
        },
        {
          "symbol": "MLDHR",
          "ensemblId": "ENSG00000289051",
          "biotype": "protein_coding",
          "start": 87863559,
          "end": 87863654,
          "strand": "+",
          "slug": "mldhr"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-lymph-node-morphology",
        "name": "Abnormal lymph node histology",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-lymph-node-morphology"
      },
      {
        "slug": "abnormal-neck-blood-vessel-morphology",
        "name": "Abnormality of blood vessel of neck",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-neck-blood-vessel-morphology"
      },
      {
        "slug": "abnormality-of-extrapyramidal-motor-function",
        "name": "Abnormality of extrapyramidal motor function",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-extrapyramidal-motor-function"
      },
      {
        "slug": "absent-speech",
        "name": "Absent speech development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/absent-speech"
      },
      {
        "slug": "apnea",
        "name": "Apnea",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/apnea"
      },
      {
        "slug": "bone-pain",
        "name": "Bone pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bone-pain"
      },
      {
        "slug": "chronic-lung-disease",
        "name": "Chronic lung disease",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chronic-lung-disease"
      },
      {
        "slug": "chronic-noninfectious-lymphadenopathy",
        "name": "Chronic noninfectious lymphadenopathy",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-noninfectious-lymphadenopathy"
      },
      {
        "slug": "cataract",
        "name": "Clouding of the lens of the eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cataract"
      },
      {
        "slug": "colon-cancer",
        "name": "Colon cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/colon-cancer"
      },
      {
        "slug": "cerebral-cortical-atrophy",
        "name": "Decrease in size of the outer layer of the brain due to loss of brain cells",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cerebral-cortical-atrophy"
      },
      {
        "slug": "delayed-fine-motor-development",
        "name": "Delayed fine motor development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-fine-motor-development"
      },
      {
        "slug": "delayed-gross-motor-development",
        "name": "Delayed motor skills",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-gross-motor-development"
      },
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "goiter",
        "name": "Enlarged thyroid gland in neck",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/goiter"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "follicular-thyroid-carcinoma",
        "name": "Follicular thyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/follicular-thyroid-carcinoma"
      },
      {
        "slug": "recurrent-urinary-tract-infections",
        "name": "Frequent urinary tract infections",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-urinary-tract-infections"
      },
      {
        "slug": "neoplasm-of-head-and-neck",
        "name": "Head and neck tumor",
        "systems": [
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-head-and-neck"
      },
      {
        "slug": "hypoplasia-of-the-pons",
        "name": "Hypoplasia of the pons",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-pons"
      },
      {
        "slug": "limb-hypertonia",
        "name": "Increased muscle tone of arm or leg",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/limb-hypertonia"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "axial-hypotonia",
        "name": "Low muscle tone in trunk",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/axial-hypotonia"
      },
      {
        "slug": "low-set-ears",
        "name": "Low-set ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/low-set-ears"
      },
      {
        "slug": "skeletal-muscle-atrophy",
        "name": "Muscle degeneration",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/skeletal-muscle-atrophy"
      },
      {
        "slug": "nodular-goiter",
        "name": "Nodular goiter",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/nodular-goiter"
      },
      {
        "slug": "non-medullary-thyroid-carcinoma",
        "name": "Non-medullary thyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/non-medullary-thyroid-carcinoma"
      },
      {
        "slug": "optic-atrophy",
        "name": "Optic atrophy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/optic-atrophy"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pain"
      },
      {
        "slug": "papillary-renal-cell-carcinoma",
        "name": "Papillary renal cell carcinoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/papillary-renal-cell-carcinoma"
      },
      {
        "slug": "papillary-thyroid-carcinoma",
        "name": "Papillary thyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/papillary-thyroid-carcinoma"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "spinal-cord-compression",
        "name": "Pressure on spinal cord",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/spinal-cord-compression"
      },
      {
        "slug": "prominent-nose",
        "name": "Prominent nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prominent-nose"
      },
      {
        "slug": "recurrent-fractures",
        "name": "Recurrent fractures",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-fractures"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "cerebellar-hypoplasia",
        "name": "Small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cerebellar-hypoplasia"
      },
      {
        "slug": "spastic-tetraplegia",
        "name": "Spastic tetraplegia",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/spastic-tetraplegia"
      },
      {
        "slug": "thin-corpus-callosum",
        "name": "Thin corpus callosum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thin-corpus-callosum"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}