{
  "url": "https://dantelabs.com/et/genes/itga2",
  "gene": {
    "slug": "itga2",
    "symbol": "ITGA2",
    "name": "integrin subunit alpha 2",
    "hgnc": "HGNC:6137",
    "summary": null,
    "location": "5q11.2",
    "locusType": "gene with protein product",
    "aliases": [
      "GPIa",
      "VLAA2",
      "HPA-5"
    ],
    "previousSymbols": [
      "CD49B"
    ],
    "ensemblId": "ENSG00000164171",
    "entrezId": 3673,
    "omim": [
      "192974"
    ],
    "uniprot": [
      "P17301"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "5",
      "start": 52989352,
      "end": 53094779,
      "strand": "+",
      "ensemblTranscript": "ENST00000296585.10",
      "refseqTranscript": "NM_002203.4",
      "ensemblProtein": "ENSP00000296585.5",
      "refseqProtein": "NP_002194.2",
      "exons": [
        {
          "start": 52989352,
          "end": 52989532
        },
        {
          "start": 53026748,
          "end": 53026868
        },
        {
          "start": 53042112,
          "end": 53042221
        },
        {
          "start": 53045001,
          "end": 53045092
        },
        {
          "start": 53048363,
          "end": 53048477
        },
        {
          "start": 53048643,
          "end": 53048770
        },
        {
          "start": 53051411,
          "end": 53051559
        },
        {
          "start": 53055538,
          "end": 53055688
        },
        {
          "start": 53055984,
          "end": 53056149
        },
        {
          "start": 53058025,
          "end": 53058101
        },
        {
          "start": 53059874,
          "end": 53060012
        },
        {
          "start": 53060901,
          "end": 53061046
        },
        {
          "start": 53062786,
          "end": 53062929
        },
        {
          "start": 53064912,
          "end": 53065115
        },
        {
          "start": 53065841,
          "end": 53065977
        },
        {
          "start": 53067118,
          "end": 53067257
        },
        {
          "start": 53070109,
          "end": 53070260
        },
        {
          "start": 53071938,
          "end": 53072048
        },
        {
          "start": 53072613,
          "end": 53072695
        },
        {
          "start": 53073118,
          "end": 53073259
        },
        {
          "start": 53074385,
          "end": 53074477
        },
        {
          "start": 53075061,
          "end": 53075137
        },
        {
          "start": 53075221,
          "end": 53075304
        },
        {
          "start": 53078772,
          "end": 53078874
        },
        {
          "start": 53080511,
          "end": 53080621
        },
        {
          "start": 53081592,
          "end": 53081696
        },
        {
          "start": 53083340,
          "end": 53083453
        },
        {
          "start": 53086952,
          "end": 53087041
        },
        {
          "start": 53089946,
          "end": 53090062
        },
        {
          "start": 53090519,
          "end": 53094779
        }
      ],
      "cds": {
        "start": 52989469,
        "end": 53090599
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "5",
      "start": 52285156,
      "end": 52390609,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 52542066,
      "end": 53542065,
      "genes": [
        {
          "symbol": "PELO",
          "ensemblId": "ENSG00000152684",
          "biotype": "protein_coding",
          "start": 52787621,
          "end": 52807447,
          "strand": "+",
          "slug": "pelo"
        },
        {
          "symbol": "ITGA1",
          "ensemblId": "ENSG00000213949",
          "biotype": "protein_coding",
          "start": 52787621,
          "end": 52961951,
          "strand": "+",
          "slug": "itga1"
        },
        {
          "symbol": "MOCS2",
          "ensemblId": "ENSG00000164172",
          "biotype": "protein_coding",
          "start": 53094141,
          "end": 53113016,
          "strand": "-",
          "slug": "mocs2"
        },
        {
          "symbol": "FST",
          "ensemblId": "ENSG00000134363",
          "biotype": "protein_coding",
          "start": 53479819,
          "end": 53487134,
          "strand": "+",
          "slug": "fst"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "systems": [],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      },
      {
        "slug": "bilateral-sensorineural-hearing-impairment",
        "name": "Bilateral sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/bilateral-sensorineural-hearing-impairment"
      },
      {
        "slug": "melena",
        "name": "Black feces",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/melena"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "intracranial-hemorrhage",
        "name": "Bleeding within the skull",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intracranial-hemorrhage"
      },
      {
        "slug": "blindness",
        "name": "Blindness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/blindness"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "purpura",
        "name": "Blood spots",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/purpura"
      },
      {
        "slug": "cephalohematoma",
        "name": "Cephalohematoma",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cephalohematoma"
      },
      {
        "slug": "cerebral-palsy",
        "name": "Cerebral palsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/cerebral-palsy"
      },
      {
        "slug": "ecchymosis",
        "name": "Ecchymosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ecchymosis"
      },
      {
        "slug": "gastrointestinal-hemorrhage",
        "name": "Gastrointestinal bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastrointestinal-hemorrhage"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "neonatal-alloimmune-thrombocytopenia",
        "name": "Neonatal alloimmune thrombocytopenia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/neonatal-alloimmune-thrombocytopenia"
      },
      {
        "slug": "petechiae",
        "name": "Petechiae",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/petechiae"
      },
      {
        "slug": "spontaneous-hematomas",
        "name": "Spontaneous hematomas",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/spontaneous-hematomas"
      },
      {
        "slug": "subarachnoid-hemorrhage",
        "name": "Subarachnoid hemorrhage",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/subarachnoid-hemorrhage"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}