{
  "url": "https://dantelabs.com/et/genes/gdf5",
  "gene": {
    "slug": "gdf5",
    "symbol": "GDF5",
    "name": "growth differentiation factor 5",
    "hgnc": "HGNC:4220",
    "summary": null,
    "location": "20q11.22",
    "locusType": "gene with protein product",
    "aliases": [
      "CDMP1",
      "BMP14"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000125965",
    "entrezId": 8200,
    "omim": [
      "601146"
    ],
    "uniprot": [
      "P43026"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "20",
      "start": 35433347,
      "end": 35438228,
      "strand": "-",
      "ensemblTranscript": "ENST00000374369.8",
      "refseqTranscript": "NM_000557.5",
      "ensemblProtein": "ENSP00000363489.3",
      "refseqProtein": "NP_000548.2",
      "exons": [
        {
          "start": 35433347,
          "end": 35434783
        },
        {
          "start": 35437298,
          "end": 35438228
        }
      ],
      "cds": {
        "start": 35433909,
        "end": 35437928
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "20",
      "start": 34021145,
      "end": 34042568,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 34935788,
      "end": 35935787,
      "genes": [
        {
          "symbol": "GSS",
          "ensemblId": "ENSG00000100983",
          "biotype": "protein_coding",
          "start": 34928432,
          "end": 34956027,
          "strand": "-",
          "slug": "gss"
        },
        {
          "symbol": "MYH7B",
          "ensemblId": "ENSG00000078814",
          "biotype": "protein_coding",
          "start": 34955810,
          "end": 35002440,
          "strand": "+",
          "slug": "myh7b"
        },
        {
          "symbol": "TRPC4AP",
          "ensemblId": "ENSG00000100991",
          "biotype": "protein_coding",
          "start": 34995209,
          "end": 35092868,
          "strand": "-",
          "slug": "trpc4ap"
        },
        {
          "symbol": "EDEM2",
          "ensemblId": "ENSG00000088298",
          "biotype": "protein_coding",
          "start": 35113122,
          "end": 35147404,
          "strand": "-",
          "slug": "edem2"
        },
        {
          "symbol": "PROCR",
          "ensemblId": "ENSG00000101000",
          "biotype": "protein_coding",
          "start": 35153330,
          "end": 35216253,
          "strand": "+",
          "slug": "procr"
        },
        {
          "symbol": "MMP24OS",
          "ensemblId": "ENSG00000126005",
          "biotype": "protein_coding",
          "start": 35201745,
          "end": 35278131,
          "strand": "-",
          "slug": "mmp24os"
        },
        {
          "symbol": "MMP24",
          "ensemblId": "ENSG00000125966",
          "biotype": "protein_coding",
          "start": 35226559,
          "end": 35277030,
          "strand": "+",
          "slug": "mmp24"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000261582",
          "biotype": "protein_coding",
          "start": 35267885,
          "end": 35280043,
          "strand": "-"
        },
        {
          "symbol": "EIF6",
          "ensemblId": "ENSG00000242372",
          "biotype": "protein_coding",
          "start": 35278891,
          "end": 35285009,
          "strand": "-",
          "slug": "eif6"
        },
        {
          "symbol": "SACK1C",
          "ensemblId": "ENSG00000125998",
          "biotype": "protein_coding",
          "start": 35285731,
          "end": 35292425,
          "strand": "-",
          "slug": "sack1c"
        },
        {
          "symbol": "UQCC1",
          "ensemblId": "ENSG00000101019",
          "biotype": "protein_coding",
          "start": 35301219,
          "end": 35412070,
          "strand": "-",
          "slug": "uqcc1"
        },
        {
          "symbol": "CEP250",
          "ensemblId": "ENSG00000126001",
          "biotype": "protein_coding",
          "start": 35455131,
          "end": 35519280,
          "strand": "+",
          "slug": "cep250"
        },
        {
          "symbol": "C20orf173",
          "ensemblId": "ENSG00000125975",
          "biotype": "protein_coding",
          "start": 35523186,
          "end": 35529652,
          "strand": "-",
          "slug": "c20orf173"
        },
        {
          "symbol": "ERGIC3",
          "ensemblId": "ENSG00000125991",
          "biotype": "protein_coding",
          "start": 35542022,
          "end": 35557634,
          "strand": "+",
          "slug": "ergic3"
        },
        {
          "symbol": "SPAG4",
          "ensemblId": "ENSG00000061656",
          "biotype": "protein_coding",
          "start": 35615594,
          "end": 35621613,
          "strand": "+",
          "slug": "spag4"
        },
        {
          "symbol": "CPNE1",
          "ensemblId": "ENSG00000214078",
          "biotype": "protein_coding",
          "start": 35626031,
          "end": 35664962,
          "strand": "-",
          "slug": "cpne1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000272897",
          "biotype": "protein_coding",
          "start": 35632340,
          "end": 35674544,
          "strand": "-"
        },
        {
          "symbol": "RBM12",
          "ensemblId": "ENSG00000244462",
          "biotype": "protein_coding",
          "start": 35648925,
          "end": 35664956,
          "strand": "-",
          "slug": "rbm12"
        },
        {
          "symbol": "NFS1",
          "ensemblId": "ENSG00000244005",
          "biotype": "protein_coding",
          "start": 35668052,
          "end": 35699376,
          "strand": "-",
          "slug": "nfs1"
        },
        {
          "symbol": "ROMO1",
          "ensemblId": "ENSG00000125995",
          "biotype": "protein_coding",
          "start": 35699228,
          "end": 35703939,
          "strand": "+",
          "slug": "romo1"
        },
        {
          "symbol": "RBM39",
          "ensemblId": "ENSG00000131051",
          "biotype": "protein_coding",
          "start": 35701347,
          "end": 35742312,
          "strand": "-",
          "slug": "rbm39"
        },
        {
          "symbol": "PHF20",
          "ensemblId": "ENSG00000025293",
          "biotype": "protein_coding",
          "start": 35771947,
          "end": 35950385,
          "strand": "+",
          "slug": "phf20"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "achondrogenesis-panel",
        "name": "Akondrogeneesi paneel",
        "diseases": [
          {
            "mondoId": "MONDO:0019648",
            "name": "Akondrogeneesi",
            "genes": 4,
            "inheritance": null,
            "description": "Akondrogeneesi on haruldaste, letaalsete luustiku düsplaasiate rühm, mida iseloomustab endohondraalse luustumise puudulikkus. See viib kääbuskasvu, väga lühikeste jäsemete (ekstreemne mikromeelia), väikese rinnkere, silmatorkava kõhu, anasarkaa ja polühüdramnioonini. Akondrogeneesil on kolm tüüpi, mis erinevad kliiniliselt, radioloogiliselt, histoloogiliselt ja geneetiliselt: akondrogeneesi tüüp 1a, tüüp 1b ja tüüp 2.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/et/conditions/achondrogenesis-panel"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-finger-flexion-crease",
        "name": "Abnormal finger flexion crease",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-finger-flexion-crease"
      },
      {
        "slug": "abnormal-fingernail-morphology",
        "name": "Abnormal fingernails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-fingernail-morphology"
      },
      {
        "slug": "hip-dysplasia",
        "name": "Abnormal formation of the hip",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hip-dysplasia"
      },
      {
        "slug": "abnormal-morphology-of-the-radius",
        "name": "Abnormal morphology of the radius",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-morphology-of-the-radius"
      },
      {
        "slug": "abnormal-morphology-of-ulna",
        "name": "Abnormal morphology of ulna",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-morphology-of-ulna"
      },
      {
        "slug": "abnormal-epiphysis-morphology",
        "name": "Abnormal shape of end part of bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-epiphysis-morphology"
      },
      {
        "slug": "abnormal-metacarpal-morphology",
        "name": "Abnormal shape of long bones of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-metacarpal-morphology"
      },
      {
        "slug": "abnormal-pelvic-girdle-bone-morphology",
        "name": "Abnormal shape of pelvic girdle bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-pelvic-girdle-bone-morphology"
      },
      {
        "slug": "skeletal-dysplasia",
        "name": "Abnormal skeletal development",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/skeletal-dysplasia"
      },
      {
        "slug": "abnormal-speech-pattern",
        "name": "Abnormal speech pattern",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-speech-pattern"
      },
      {
        "slug": "abnormality-of-the-ankle",
        "name": "Abnormality of the ankle",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ankle"
      },
      {
        "slug": "abnormal-hip-bone-morphology",
        "name": "Abnormality of the hip bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-hip-bone-morphology"
      },
      {
        "slug": "abnormal-nail-morphology",
        "name": "Abnormality of the nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-nail-morphology"
      },
      {
        "slug": "abnormal-tibia-morphology",
        "name": "Abnormality of the shankbone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-tibia-morphology"
      },
      {
        "slug": "abnormal-thumb-morphology",
        "name": "Abnormality of the thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-thumb-morphology"
      },
      {
        "slug": "abnormality-of-the-wrist",
        "name": "Abnormality of the wrist",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-wrist"
      },
      {
        "slug": "abnormally-shaped-carpal-bones",
        "name": "Abnormally shaped wrist bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormally-shaped-carpal-bones"
      },
      {
        "slug": "fibular-aplasia",
        "name": "Absent calf bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/fibular-aplasia"
      },
      {
        "slug": "aplasia-of-the-middle-phalanges-of-the-toes",
        "name": "Absent middle toe bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-of-the-middle-phalanges-of-the-toes"
      },
      {
        "slug": "absent-toe",
        "name": "Absent toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/absent-toe"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-1st-metacarpal",
        "name": "Absent/small 1st long bone of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-1st-metacarpal"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-fibula",
        "name": "Absent/small calf bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-fibula"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-patella",
        "name": "Absent/small kneecap",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-patella"
      },
      {
        "slug": "aplasia-hypoplasia-of-metatarsal-bones",
        "name": "Absent/small long bone of foot",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-metatarsal-bones"
      },
      {
        "slug": "aplasia-hypoplasia-involving-the-metacarpal-bones",
        "name": "Absent/small long bones of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-the-metacarpal-bones"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-middle-phalanx-of-the-5th-finger",
        "name": "Absent/small middle bone of pinky finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-middle-phalanx-of-the-5th-finger"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-middle-phalanx-of-the-2nd-finger",
        "name": "Absent/small middle index finger bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-middle-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-thumb",
        "name": "Absent/small thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-thumb"
      },
      {
        "slug": "aplastic-hypoplastic-toenail",
        "name": "Absent/small toenails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/aplastic-hypoplastic-toenail"
      },
      {
        "slug": "acromesomelia",
        "name": "Acromesomelia",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/acromesomelia"
      },
      {
        "slug": "angel-shaped-phalanx",
        "name": "Angel-shaped phalanx",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/angel-shaped-phalanx"
      },
      {
        "slug": "deviation-of-finger",
        "name": "Atypical position of finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/deviation-of-finger"
      },
      {
        "slug": "bilateral-single-transverse-palmar-creases",
        "name": "Bilateral single transverse palmar creases",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/bilateral-single-transverse-palmar-creases"
      },
      {
        "slug": "radial-bowing",
        "name": "Bowing of outer large bone of the forearm",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/radial-bowing"
      },
      {
        "slug": "bowing-of-the-long-bones",
        "name": "Bowing of the long bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/bowing-of-the-long-bones"
      },
      {
        "slug": "broad-hallux",
        "name": "Broad big toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/broad-hallux"
      },
      {
        "slug": "broad-thumb",
        "name": "Broad thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/broad-thumb"
      },
      {
        "slug": "hallux-valgus",
        "name": "Bunion",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hallux-valgus"
      },
      {
        "slug": "sarcoma",
        "name": "Cancer of connective tissue",
        "systems": [
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sarcoma"
      },
      {
        "slug": "talipes-equinovarus",
        "name": "Club feet",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/talipes-equinovarus"
      },
      {
        "slug": "bilateral-talipes-equinovarus",
        "name": "Club foot on both sides",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bilateral-talipes-equinovarus"
      },
      {
        "slug": "cognitive-impairment",
        "name": "Cognitive impairment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cognitive-impairment"
      },
      {
        "slug": "complete-duplication-of-distal-phalanx-of-the-thumb",
        "name": "Complete duplication of outermost bone of the thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/complete-duplication-of-distal-phalanx-of-the-thumb"
      },
      {
        "slug": "conductive-hearing-impairment",
        "name": "Conductive deafness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/conductive-hearing-impairment"
      },
      {
        "slug": "cone-shaped-epiphysis",
        "name": "Cone-shaped end part of bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cone-shaped-epiphysis"
      },
      {
        "slug": "cone-shaped-epiphyses-of-the-middle-phalanges-of-the-hand",
        "name": "Cone-shaped end part of the middle hand bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cone-shaped-epiphyses-of-the-middle-phalanges-of-the-hand"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "finger-clinodactyly",
        "name": "Curvature of finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/finger-clinodactyly"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "deformed-tarsal-bones",
        "name": "Deformed ankle bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/deformed-tarsal-bones"
      },
      {
        "slug": "delayed-skeletal-maturation",
        "name": "Delayed bone maturation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-skeletal-maturation"
      },
      {
        "slug": "delayed-eruption-of-teeth",
        "name": "Delayed eruption of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-eruption-of-teeth"
      },
      {
        "slug": "patellar-dislocation",
        "name": "Dislocated kneecap",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/patellar-dislocation"
      },
      {
        "slug": "disproportionate-short-limb-short-stature",
        "name": "Disproportionate short-limb short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/disproportionate-short-limb-short-stature"
      },
      {
        "slug": "rhizomelia",
        "name": "Disproportionately short upper portion of limb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system",
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/rhizomelia"
      },
      {
        "slug": "distal-femoral-bowing",
        "name": "Distal femoral bowing",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/distal-femoral-bowing"
      },
      {
        "slug": "distal-tibiofibular-synostosis",
        "name": "Distal tibiofibular synostosis",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/distal-tibiofibular-synostosis"
      },
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      },
      {
        "slug": "pes-planus",
        "name": "Dropped arches",
        "systems": [
          "abnormality-of-limbs"
        ],
        "url": "https://dantelabs.com/traits/pes-planus"
      },
      {
        "slug": "elbow-ankylosis",
        "name": "Elbow ankylosis",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elbow-ankylosis"
      },
      {
        "slug": "elbow-dislocation",
        "name": "Elbow dislocation",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/elbow-dislocation"
      },
      {
        "slug": "enlarged-epiphysis-of-the-proximal-phalanx-of-the-2nd-finger",
        "name": "Enlarged end part of innermost long bone of index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enlarged-epiphysis-of-the-proximal-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "enlarged-epiphysis-of-the-proximal-phalanx-of-the-3rd-finger",
        "name": "Enlarged end part of innermost long bone of the middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enlarged-epiphysis-of-the-proximal-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "enlarged-epiphysis-of-the-middle-phalanx-of-the-2nd-finger",
        "name": "Enlarged end part of the middle bone of the index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enlarged-epiphysis-of-the-middle-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "enlarged-epiphysis-of-the-middle-phalanx-of-the-3rd-finger",
        "name": "Enlarged end part of the middle bone of the middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/enlarged-epiphysis-of-the-middle-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "postaxial-hand-polydactyly",
        "name": "Extra little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/postaxial-hand-polydactyly"
      },
      {
        "slug": "facial-asymmetry",
        "name": "Facial asymmetry",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/facial-asymmetry"
      },
      {
        "slug": "hypodontia",
        "name": "Failure of development of between one and six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypodontia"
      },
      {
        "slug": "fibular-torsion",
        "name": "Fibular torsion",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/fibular-torsion"
      },
      {
        "slug": "ulnar-deviation-of-finger",
        "name": "Finger bends toward pinky",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/ulnar-deviation-of-finger"
      },
      {
        "slug": "finger-syndactyly",
        "name": "Finger syndactyly",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/finger-syndactyly"
      },
      {
        "slug": "flexion-contracture",
        "name": "Flexed joint that cannot be straightened",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/flexion-contracture"
      },
      {
        "slug": "tarsal-synostosis",
        "name": "Fused ankle bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/tarsal-synostosis"
      },
      {
        "slug": "finger-symphalangism",
        "name": "Fused finger bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/finger-symphalangism"
      },
      {
        "slug": "proximal-fifth-finger-symphalangism",
        "name": "Fused innermost and middle bones of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/proximal-fifth-finger-symphalangism"
      },
      {
        "slug": "metacarpophalangeal-synostosis",
        "name": "Fused long bone of hand with innermost finger bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/metacarpophalangeal-synostosis"
      },
      {
        "slug": "distal-finger-symphalangism",
        "name": "Fused outermost bones of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/distal-finger-symphalangism"
      },
      {
        "slug": "carpal-synostosis",
        "name": "Fused wrist bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/carpal-synostosis"
      },
      {
        "slug": "humeroradial-synostosis",
        "name": "Fusion of upper and lower arm bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/humeroradial-synostosis"
      },
      {
        "slug": "synostosis-of-carpal-bones",
        "name": "Fusion of wrist bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/synostosis-of-carpal-bones"
      },
      {
        "slug": "hip-dislocation",
        "name": "Hip dislocation",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hip-dislocation"
      },
      {
        "slug": "hip-osteoarthritis",
        "name": "Hip osteoarthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hip-osteoarthritis"
      },
      {
        "slug": "hypersegmentation-of-proximal-phalanx-of-second-finger",
        "name": "Hypersegmentation of proximal phalanx of second finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hypersegmentation-of-proximal-phalanx-of-second-finger"
      },
      {
        "slug": "hypersegmentation-of-proximal-phalanx-of-third-finger",
        "name": "Hypersegmentation of proximal phalanx of third finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hypersegmentation-of-proximal-phalanx-of-third-finger"
      },
      {
        "slug": "malaligned-carpal-bone",
        "name": "Incorrect alignment of wrist bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/malaligned-carpal-bone"
      },
      {
        "slug": "joint-stiffness",
        "name": "Joint stiffness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/joint-stiffness"
      },
      {
        "slug": "limitation-of-joint-mobility",
        "name": "Limitation of joint mobility",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/limitation-of-joint-mobility"
      },
      {
        "slug": "madelung-deformity",
        "name": "Madelung deformity",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/madelung-deformity"
      },
      {
        "slug": "medially-deviated-second-toe",
        "name": "Medially deviated second toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/medially-deviated-second-toe"
      },
      {
        "slug": "metatarsus-valgus",
        "name": "Metatarsus valgus",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/metatarsus-valgus"
      },
      {
        "slug": "narrow-nasal-bridge",
        "name": "Narrow nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/narrow-nasal-bridge"
      },
      {
        "slug": "camptodactyly-of-finger",
        "name": "Permanent flexion of the finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/camptodactyly-of-finger"
      },
      {
        "slug": "pes-valgus",
        "name": "Pes valgus",
        "systems": [
          "abnormality-of-limbs"
        ],
        "url": "https://dantelabs.com/traits/pes-valgus"
      },
      {
        "slug": "proximal-symphalangism",
        "name": "Proximal symphalangism",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/proximal-symphalangism"
      },
      {
        "slug": "pseudoepiphyses-of-the-3rd-finger",
        "name": "Pseudoepiphyses of the 3rd finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pseudoepiphyses-of-the-3rd-finger"
      },
      {
        "slug": "pseudoepiphysis-of-the-2nd-finger",
        "name": "Pseudoepiphysis of the 2nd finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pseudoepiphysis-of-the-2nd-finger"
      },
      {
        "slug": "radial-deviation-of-the-2nd-finger",
        "name": "Radial deviation of the 2nd finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/radial-deviation-of-the-2nd-finger"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "severe-short-limb-dwarfism",
        "name": "Severe short-limb dwarfism",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/severe-short-limb-dwarfism"
      },
      {
        "slug": "short-3rd-finger",
        "name": "Short 3rd finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-3rd-finger"
      },
      {
        "slug": "short-hallux",
        "name": "Short big toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-hallux"
      },
      {
        "slug": "fibular-hypoplasia",
        "name": "Short calf bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fibular-hypoplasia"
      },
      {
        "slug": "short-digit",
        "name": "Short digit",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/short-digit"
      },
      {
        "slug": "short-phalanx-of-finger",
        "name": "Short finger bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-phalanx-of-finger"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "short-foot",
        "name": "Short foot",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-foot"
      },
      {
        "slug": "short-humerus",
        "name": "Short humerus",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/short-humerus"
      },
      {
        "slug": "short-2nd-finger",
        "name": "Short index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-2nd-finger"
      },
      {
        "slug": "type-a2-brachydactyly",
        "name": "Short index fingers and second toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/type-a2-brachydactyly"
      },
      {
        "slug": "short-metatarsal",
        "name": "Short long bone of foot",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-metatarsal"
      },
      {
        "slug": "short-middle-phalanx-of-the-4th-finger",
        "name": "Short middle bone of 4th finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-middle-phalanx-of-the-4th-finger"
      },
      {
        "slug": "short-middle-phalanx-of-finger",
        "name": "Short middle bone of finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-middle-phalanx-of-finger"
      },
      {
        "slug": "short-middle-phalanx-of-the-2nd-finger",
        "name": "Short middle bone of index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-middle-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "short-middle-phalanx-of-the-3rd-finger",
        "name": "Short middle bone of middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-middle-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "short-middle-phalanx-of-the-5th-finger",
        "name": "Short middle bone of the little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-middle-phalanx-of-the-5th-finger"
      },
      {
        "slug": "short-distal-phalanx-of-finger",
        "name": "Short outermost finger bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/short-distal-phalanx-of-finger"
      },
      {
        "slug": "short-palm",
        "name": "Short palm",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-palm"
      },
      {
        "slug": "short-tibia",
        "name": "Short shinbone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-tibia"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "short-femur",
        "name": "Short thighbone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/short-femur"
      },
      {
        "slug": "short-thumb",
        "name": "Short thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-thumb"
      },
      {
        "slug": "short-toe",
        "name": "Short toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-toe"
      },
      {
        "slug": "cuboidal-metacarpal",
        "name": "Short, cube shaped long bone of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cuboidal-metacarpal"
      },
      {
        "slug": "short-1st-metacarpal",
        "name": "Shortened 1st long bone of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-1st-metacarpal"
      },
      {
        "slug": "short-2nd-metacarpal",
        "name": "Shortened 2nd long bone of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-2nd-metacarpal"
      },
      {
        "slug": "short-metacarpal",
        "name": "Shortened long bone of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-metacarpal"
      },
      {
        "slug": "shortening-of-all-proximal-phalanges-of-the-fingers",
        "name": "Shortening of all innermost bones of the fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/shortening-of-all-proximal-phalanges-of-the-fingers"
      },
      {
        "slug": "shortening-of-all-middle-phalanges-of-the-fingers",
        "name": "Shortening of all middle phalanges of the fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/shortening-of-all-middle-phalanges-of-the-fingers"
      },
      {
        "slug": "single-transverse-palmar-crease",
        "name": "Single transverse palmar crease",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/single-transverse-palmar-crease"
      },
      {
        "slug": "small-nail",
        "name": "Small nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/small-nail"
      },
      {
        "slug": "micromelia",
        "name": "Smaller or shorter than typical limbs",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/micromelia"
      },
      {
        "slug": "stippling-of-the-epiphysis-of-the-distal-phalanx-of-the-thumb",
        "name": "Speckled calcifications in the end part of the outermost thumb bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stippling-of-the-epiphysis-of-the-distal-phalanx-of-the-thumb"
      },
      {
        "slug": "talipes-equinovalgus",
        "name": "Talipes equinovalgus",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/talipes-equinovalgus"
      },
      {
        "slug": "tibiotalar-synostosis",
        "name": "Tibiotalar synostosis",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/tibiotalar-synostosis"
      },
      {
        "slug": "triangular-epiphysis-of-the-proximal-phalanx-of-the-2nd-finger",
        "name": "Triangular end part of innermost long bone of index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-epiphysis-of-the-proximal-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "triangular-epiphysis-of-the-proximal-phalanx-of-the-3rd-finger",
        "name": "Triangular end part of innermost long bone of the middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-epiphysis-of-the-proximal-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "triangular-epiphysis-of-the-middle-phalanx-of-the-2nd-finger",
        "name": "Triangular end part of the middle bone of the index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-epiphysis-of-the-middle-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "triangular-epiphysis-of-the-middle-phalanx-of-the-3rd-finger",
        "name": "Triangular end part of the middle bone of the middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-epiphysis-of-the-middle-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "triangular-shaped-proximal-phalanx-of-the-2nd-finger",
        "name": "Triangular shaped innermost bone of index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-shaped-proximal-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "triangular-shaped-proximal-phalanx-of-the-3rd-finger",
        "name": "Triangular shaped innermost bone of middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-shaped-proximal-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "triangular-shaped-middle-phalanx-of-the-2nd-finger",
        "name": "Triangular shaped middle bone of index finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-shaped-middle-phalanx-of-the-2nd-finger"
      },
      {
        "slug": "triangular-shaped-middle-phalanx-of-the-3rd-finger",
        "name": "Triangular shaped middle bone of the middle finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/triangular-shaped-middle-phalanx-of-the-3rd-finger"
      },
      {
        "slug": "triangular-shaped-middle-phalanx-of-the-5th-finger",
        "name": "Triangular shaped middle little finger bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/triangular-shaped-middle-phalanx-of-the-5th-finger"
      },
      {
        "slug": "type-c-brachydactyly",
        "name": "Type C brachydactyly",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/type-c-brachydactyly"
      },
      {
        "slug": "ulnar-deviation-of-the-2nd-finger",
        "name": "Ulnar deviation of the 2nd finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ulnar-deviation-of-the-2nd-finger"
      },
      {
        "slug": "ulnar-deviation-of-the-3rd-finger",
        "name": "Ulnar deviation of the 3rd finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ulnar-deviation-of-the-3rd-finger"
      },
      {
        "slug": "hypoplasia-of-the-ulna",
        "name": "Underdeveloped inner large forearm bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-ulna"
      },
      {
        "slug": "hypoplasia-of-the-radius",
        "name": "Underdeveloped outer large forearm bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-radius"
      },
      {
        "slug": "valgus-hand-deformity",
        "name": "Valgus hand deformity",
        "systems": [
          "abnormality-of-limbs"
        ],
        "url": "https://dantelabs.com/traits/valgus-hand-deformity"
      },
      {
        "slug": "vertebral-fusion",
        "name": "Vertebral fusion",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/vertebral-fusion"
      },
      {
        "slug": "2-3-toe-syndactyly",
        "name": "Webbed 2nd and 3rd toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/2-3-toe-syndactyly"
      },
      {
        "slug": "broad-metacarpals",
        "name": "Wide long bones of hand",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/broad-metacarpals"
      },
      {
        "slug": "wide-nose",
        "name": "Wide nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/wide-nose"
      }
    ],
    "related": [
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "name": "collagen type II alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/et/genes/col2a1"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "name": "solute carrier family 26 member 2",
        "shared": 1,
        "url": "https://dantelabs.com/et/genes/slc26a2"
      },
      {
        "slug": "trip11",
        "symbol": "TRIP11",
        "name": "thyroid hormone receptor interactor 11",
        "shared": 1,
        "url": "https://dantelabs.com/et/genes/trip11"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}