{
  "url": "https://dantelabs.com/et/genes/cyp4f2",
  "gene": {
    "slug": "cyp4f2",
    "symbol": "CYP4F2",
    "name": "cytochrome P450 family 4 subfamily F member 2",
    "hgnc": "HGNC:2645",
    "summary": null,
    "location": "19p13.12",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000186115",
    "entrezId": 8529,
    "omim": [
      "604426"
    ],
    "uniprot": [
      "P78329"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "19",
      "start": 15878023,
      "end": 15898074,
      "strand": "-",
      "ensemblTranscript": "ENST00000221700.11",
      "refseqTranscript": "NM_001082.5",
      "ensemblProtein": "ENSP00000221700.3",
      "refseqProtein": "NP_001073.3",
      "exons": [
        {
          "start": 15878023,
          "end": 15878936
        },
        {
          "start": 15879346,
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        {
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        },
        {
          "start": 15885924,
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        {
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        },
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        {
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        },
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        {
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        }
      ],
      "cds": {
        "start": 15878771,
        "end": 15897611
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "19",
      "start": 15988833,
      "end": 16008930,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 15388049,
      "end": 16388048,
      "genes": [
        {
          "symbol": "AKAP8L",
          "ensemblId": "ENSG00000011243",
          "biotype": "protein_coding",
          "start": 15380046,
          "end": 15419141,
          "strand": "-",
          "slug": "akap8l"
        },
        {
          "symbol": "WIZ",
          "ensemblId": "ENSG00000011451",
          "biotype": "protein_coding",
          "start": 15419978,
          "end": 15450038,
          "strand": "-",
          "slug": "wiz"
        },
        {
          "symbol": "RASAL3",
          "ensemblId": "ENSG00000105122",
          "biotype": "protein_coding",
          "start": 15451624,
          "end": 15464583,
          "strand": "-",
          "slug": "rasal3"
        },
        {
          "symbol": "PGLYRP2",
          "ensemblId": "ENSG00000161031",
          "biotype": "protein_coding",
          "start": 15468625,
          "end": 15498956,
          "strand": "-",
          "slug": "pglyrp2"
        },
        {
          "symbol": "CYP4F22",
          "ensemblId": "ENSG00000171954",
          "biotype": "protein_coding",
          "start": 15508477,
          "end": 15552317,
          "strand": "+",
          "slug": "cyp4f22"
        },
        {
          "symbol": "CYP4F8",
          "ensemblId": "ENSG00000186526",
          "biotype": "protein_coding",
          "start": 15615218,
          "end": 15630639,
          "strand": "+",
          "slug": "cyp4f8"
        },
        {
          "symbol": "CYP4F3",
          "ensemblId": "ENSG00000186529",
          "biotype": "protein_coding",
          "start": 15640795,
          "end": 15662825,
          "strand": "+",
          "slug": "cyp4f3"
        },
        {
          "symbol": "CYP4F12",
          "ensemblId": "ENSG00000186204",
          "biotype": "protein_coding",
          "start": 15673018,
          "end": 15698819,
          "strand": "+",
          "slug": "cyp4f12"
        },
        {
          "symbol": "OR10H2",
          "ensemblId": "ENSG00000171942",
          "biotype": "protein_coding",
          "start": 15728024,
          "end": 15729052,
          "strand": "+",
          "slug": "or10h2"
        },
        {
          "symbol": "OR10H3",
          "ensemblId": "ENSG00000171936",
          "biotype": "protein_coding",
          "start": 15737985,
          "end": 15742343,
          "strand": "+",
          "slug": "or10h3"
        },
        {
          "symbol": "OR10H5",
          "ensemblId": "ENSG00000172519",
          "biotype": "protein_coding",
          "start": 15787661,
          "end": 15800357,
          "strand": "+",
          "slug": "or10h5"
        },
        {
          "symbol": "OR10H1",
          "ensemblId": "ENSG00000186723",
          "biotype": "protein_coding",
          "start": 15804549,
          "end": 15815664,
          "strand": "-",
          "slug": "or10h1"
        },
        {
          "symbol": "CYP4F11",
          "ensemblId": "ENSG00000171903",
          "biotype": "protein_coding",
          "start": 15912367,
          "end": 15934933,
          "strand": "-",
          "slug": "cyp4f11"
        },
        {
          "symbol": "OR10H4",
          "ensemblId": "ENSG00000176231",
          "biotype": "protein_coding",
          "start": 15944299,
          "end": 15950350,
          "strand": "+",
          "slug": "or10h4"
        },
        {
          "symbol": "TPM4",
          "ensemblId": "ENSG00000167460",
          "biotype": "protein_coding",
          "start": 16067021,
          "end": 16103011,
          "strand": "+",
          "slug": "tpm4"
        },
        {
          "symbol": "RAB8A",
          "ensemblId": "ENSG00000167461",
          "biotype": "protein_coding",
          "start": 16111653,
          "end": 16134235,
          "strand": "+",
          "slug": "rab8a"
        },
        {
          "symbol": "HSH2D",
          "ensemblId": "ENSG00000196684",
          "biotype": "protein_coding",
          "start": 16134028,
          "end": 16158575,
          "strand": "+",
          "slug": "hsh2d"
        },
        {
          "symbol": "CIB3",
          "ensemblId": "ENSG00000141977",
          "biotype": "protein_coding",
          "start": 16161368,
          "end": 16173525,
          "strand": "-",
          "slug": "cib3"
        },
        {
          "symbol": "FAM32A",
          "ensemblId": "ENSG00000105058",
          "biotype": "protein_coding",
          "start": 16185378,
          "end": 16192048,
          "strand": "+",
          "slug": "fam32a"
        },
        {
          "symbol": "AP1M1",
          "ensemblId": "ENSG00000072958",
          "biotype": "protein_coding",
          "start": 16197854,
          "end": 16245906,
          "strand": "+",
          "slug": "ap1m1"
        },
        {
          "symbol": "KLF2",
          "ensemblId": "ENSG00000127528",
          "biotype": "protein_coding",
          "start": 16324613,
          "end": 16328685,
          "strand": "+",
          "slug": "klf2"
        },
        {
          "symbol": "EPS15L1",
          "ensemblId": "ENSG00000127527",
          "biotype": "protein_coding",
          "start": 16354591,
          "end": 16472085,
          "strand": "-",
          "slug": "eps15l1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [
      {
        "slug": "pharmacogenomics",
        "title": "Varfariini annusevajadus",
        "summary": "CYP4F2 eemaldab K-vitamiini ringlusest. *3 alleel jätab rohkem K-vitamiini kättesaadavaks, seega vajavad kandjad tavaliselt sama toime saavutamiseks veidi suuremat varfariini annust.",
        "actionable": [
          "Omab mõtet ainult ühe sisendina varfariini annustamise algoritmis koos CYP2C9 ja VKORC1-ga."
        ],
        "caveat": null,
        "alleles": [
          {
            "name": "*1",
            "reference": true
          },
          {
            "name": "*3",
            "reference": false
          }
        ],
        "phenotypes": [],
        "drugs": [
          {
            "name": "warfarin",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2C9, VKORC1, CYP4F2 and Warfarin",
              "url": "https://www.clinpgx.org/guideline/PA166251465"
            }
          },
          {
            "name": "acenocoumarol",
            "cpicLevel": "B",
            "clinpgxLevel": "2A"
          },
          {
            "name": "phenprocoumon",
            "cpicLevel": "B",
            "clinpgxLevel": "3"
          }
        ],
        "name": "Farmakogenomika",
        "url": "https://dantelabs.com/et/whole-genome-sequencing/pharmacogenomics"
      }
    ],
    "traits": [],
    "phenotypes": [],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}