{
  "url": "https://dantelabs.com/traits/tonic-pupil",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "tonic-pupil",
    "id": "HP:0012074",
    "name": "Tonic pupil",
    "definition": "An abnormality of the pupillary light reaction characterized by a marked slowing of the light reaction of usually just one pupil. The pupil tends to be relatively dilated, and there is reduced accommodation.",
    "synonyms": [
      "Adie pupil",
      "Adie's tonic pupil"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-pupillary-function",
        "name": "Abnormal pupillary function",
        "url": "https://dantelabs.com/traits/abnormal-pupillary-function"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "pmp22",
        "symbol": "PMP22",
        "hgnc": "HGNC:9118",
        "name": "peripheral myelin protein 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp22"
      },
      {
        "slug": "prorp",
        "symbol": "PRORP",
        "hgnc": "HGNC:19958",
        "name": "protein only RNase P catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prorp"
      },
      {
        "slug": "mpz",
        "symbol": "MPZ",
        "hgnc": "HGNC:7225",
        "name": "myelin protein zero",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpz"
      }
    ]
  }
}