{
  "url": "https://dantelabs.com/traits/spherophakia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "spherophakia",
    "id": "HP:0034375",
    "name": "Spherophakia",
    "definition": "Spherophakia is a rare congenital condition that presents with weak zonules around a more spherical crystalline lens with an increased anteroposterior thickness of the lens, and highly myopic eye. The lens zonules are developmentally hypoplastic and abnormally weak and due to non-attachment of the posterior zonules to the equatorial zone of the lens, the lens changes its normal shape to spherical.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-lens-shape",
        "name": "Abnormality of lens shape",
        "url": "https://dantelabs.com/traits/abnormality-of-lens-shape"
      }
    ],
    "narrower": [
      {
        "slug": "microspherophakia",
        "name": "Microspherophakia",
        "genes": 8,
        "url": "https://dantelabs.com/traits/microspherophakia"
      }
    ],
    "genes": [
      {
        "slug": "asph",
        "symbol": "ASPH",
        "hgnc": "HGNC:757",
        "name": "aspartate beta-hydroxylase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asph"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      }
    ]
  }
}