{
  "url": "https://dantelabs.com/traits/short-face",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "short-face",
    "id": "HP:0011219",
    "name": "Short face",
    "definition": "Facial height (length) is more than two standard deviations below the mean (objective); or an apparent decrease in the height (length) of the face (subjective).",
    "synonyms": [
      "Decreased height of face",
      "Decreased length of face",
      "Vertical shortening of face",
      "Decreased vertical dimension of face",
      "Short facies",
      "Vertical deficiency of face",
      "Vertical Facial Deficiency",
      "Vertical facial insufficiency",
      "Vertical hypoplasia of face",
      "Vertical insufficiency of face"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "small-face",
        "name": "Small face",
        "url": "https://dantelabs.com/traits/small-face"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "polr1b",
        "symbol": "POLR1B",
        "hgnc": "HGNC:20454",
        "name": "RNA polymerase I subunit B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1b"
      },
      {
        "slug": "polr1c",
        "symbol": "POLR1C",
        "hgnc": "HGNC:20194",
        "name": "RNA polymerase I and III subunit C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1c"
      },
      {
        "slug": "polr1d",
        "symbol": "POLR1D",
        "hgnc": "HGNC:20422",
        "name": "RNA polymerase I and III subunit D",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1d"
      },
      {
        "slug": "tcof1",
        "symbol": "TCOF1",
        "hgnc": "HGNC:11654",
        "name": "treacle ribosome biogenesis factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcof1"
      },
      {
        "slug": "runx2",
        "symbol": "RUNX2",
        "hgnc": "HGNC:10472",
        "name": "RUNX family transcription factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx2"
      },
      {
        "slug": "eda",
        "symbol": "EDA",
        "hgnc": "HGNC:3157",
        "name": "ectodysplasin A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eda"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "grem2",
        "symbol": "GREM2",
        "hgnc": "HGNC:17655",
        "name": "gremlin 2, DAN family BMP antagonist",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem2"
      },
      {
        "slug": "grhl3",
        "symbol": "GRHL3",
        "hgnc": "HGNC:25839",
        "name": "grainyhead like transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grhl3"
      },
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "pax9",
        "symbol": "PAX9",
        "hgnc": "HGNC:8623",
        "name": "paired box 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax9"
      },
      {
        "slug": "sumo1",
        "symbol": "SUMO1",
        "hgnc": "HGNC:12502",
        "name": "small ubiquitin like modifier 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sumo1"
      },
      {
        "slug": "tgfa",
        "symbol": "TGFA",
        "hgnc": "HGNC:11765",
        "name": "transforming growth factor alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfa"
      },
      {
        "slug": "ubb",
        "symbol": "UBB",
        "hgnc": "HGNC:12463",
        "name": "ubiquitin B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubb"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10a"
      },
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "hgnc": "HGNC:12775",
        "name": "Wnt family member 10B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10b"
      }
    ]
  }
}