{
  "url": "https://dantelabs.com/traits/short-clavicles",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "short-clavicles",
    "id": "HP:0000894",
    "name": "Short collarbone",
    "label": "Short clavicles",
    "definition": "Reduced length of the clavicles.",
    "synonyms": [
      "Clavicular hypoplasia",
      "Hypoplastic clavicles",
      "Underdeveloped clavicles"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-clavicles",
        "name": "Absent/small collarbone",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-clavicles"
      }
    ],
    "narrower": [
      {
        "slug": "midclavicular-hypoplasia",
        "name": "Underdeveloped middle portion of the collarbone",
        "genes": 3,
        "url": "https://dantelabs.com/traits/midclavicular-hypoplasia"
      }
    ],
    "genes": [
      {
        "slug": "fbxl3",
        "symbol": "FBXL3",
        "hgnc": "HGNC:13599",
        "name": "F-box and leucine rich repeat protein 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxl3"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "rnu12",
        "symbol": "RNU12",
        "hgnc": "HGNC:19380",
        "name": "RNA, U12 small nuclear",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu12"
      },
      {
        "slug": "runx2",
        "symbol": "RUNX2",
        "hgnc": "HGNC:10472",
        "name": "RUNX family transcription factor 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/runx2"
      },
      {
        "slug": "dchs1",
        "symbol": "DCHS1",
        "hgnc": "HGNC:13681",
        "name": "dachsous cadherin-related 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dchs1"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "lemd2",
        "symbol": "LEMD2",
        "hgnc": "HGNC:21244",
        "name": "LEM domain nuclear envelope protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lemd2"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "twist1",
        "symbol": "TWIST1",
        "hgnc": "HGNC:12428",
        "name": "twist family bHLH transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist1"
      },
      {
        "slug": "xylt1",
        "symbol": "XYLT1",
        "hgnc": "HGNC:15516",
        "name": "xylosyltransferase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/xylt1"
      },
      {
        "slug": "cbfb",
        "symbol": "CBFB",
        "hgnc": "HGNC:1539",
        "name": "core-binding factor subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbfb"
      },
      {
        "slug": "cdc42bpb",
        "symbol": "CDC42BPB",
        "hgnc": "HGNC:1738",
        "name": "CDC42 binding protein kinase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc42bpb"
      },
      {
        "slug": "chd4",
        "symbol": "CHD4",
        "hgnc": "HGNC:1919",
        "name": "chromodomain helicase DNA binding protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd4"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "sall4",
        "symbol": "SALL4",
        "hgnc": "HGNC:15924",
        "name": "spalt like transcription factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall4"
      },
      {
        "slug": "scarf2",
        "symbol": "SCARF2",
        "hgnc": "HGNC:19869",
        "name": "scavenger receptor class F member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarf2"
      },
      {
        "slug": "srcap",
        "symbol": "SRCAP",
        "hgnc": "HGNC:16974",
        "name": "Snf2 related CREBBP activator protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/srcap"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "msx2",
        "symbol": "MSX2",
        "hgnc": "HGNC:7392",
        "name": "msh homeobox 2",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/msx2"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "b4galt7",
        "symbol": "B4GALT7",
        "hgnc": "HGNC:930",
        "name": "beta-1,4-galactosyltransferase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4galt7"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "bgn",
        "symbol": "BGN",
        "hgnc": "HGNC:1044",
        "name": "biglycan",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bgn"
      },
      {
        "slug": "dync2li1",
        "symbol": "DYNC2LI1",
        "hgnc": "HGNC:24595",
        "name": "dynein cytoplasmic 2 light intermediate chain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2li1"
      },
      {
        "slug": "fat4",
        "symbol": "FAT4",
        "hgnc": "HGNC:23109",
        "name": "FAT atypical cadherin 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fat4"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "idua",
        "symbol": "IDUA",
        "hgnc": "HGNC:5391",
        "name": "alpha-L-iduronidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idua"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "rspo2",
        "symbol": "RSPO2",
        "hgnc": "HGNC:28583",
        "name": "R-spondin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo2"
      },
      {
        "slug": "tbx3",
        "symbol": "TBX3",
        "hgnc": "HGNC:11602",
        "name": "T-box transcription factor 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx3"
      },
      {
        "slug": "trip11",
        "symbol": "TRIP11",
        "hgnc": "HGNC:12305",
        "name": "thyroid hormone receptor interactor 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip11"
      }
    ]
  }
}