{
  "url": "https://dantelabs.com/traits/senile-plaques",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "senile-plaques",
    "id": "HP:0100256",
    "name": "Senile plaques",
    "definition": "Senile plaques are extracellular deposits of amyloid in the gray matter of the brain.",
    "synonyms": [
      "Braindruse",
      "Neuritic plaques",
      "Senile druse"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "atrophy-degeneration-affecting-the-central-nervous-system",
        "name": "Atrophy/Degeneration affecting the central nervous system",
        "url": "https://dantelabs.com/traits/atrophy-degeneration-affecting-the-central-nervous-system"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "prnp",
        "symbol": "PRNP",
        "hgnc": "HGNC:9449",
        "name": "prion protein (Kanno blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prnp"
      },
      {
        "slug": "chmp2b",
        "symbol": "CHMP2B",
        "hgnc": "HGNC:24537",
        "name": "charged multivesicular body protein 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chmp2b"
      },
      {
        "slug": "grn",
        "symbol": "GRN",
        "hgnc": "HGNC:4601",
        "name": "granulin precursor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grn"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "tmem106b",
        "symbol": "TMEM106B",
        "hgnc": "HGNC:22407",
        "name": "transmembrane protein 106B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem106b"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "abca7",
        "symbol": "ABCA7",
        "hgnc": "HGNC:37",
        "name": "ATP binding cassette subfamily A member 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca7"
      },
      {
        "slug": "apoe",
        "symbol": "APOE",
        "hgnc": "HGNC:613",
        "name": "apolipoprotein E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoe"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      }
    ]
  }
}