{
  "url": "https://dantelabs.com/traits/primary-hyperaldosteronism",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "primary-hyperaldosteronism",
    "id": "HP:0011736",
    "name": "Primary hyperaldosteronism",
    "definition": "A form of hyperaldosteronism caused by a defect within the adrenal gland.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "increased-circulating-aldosterone-concentration",
        "name": "Elevated plasma aldosterone",
        "url": "https://dantelabs.com/traits/increased-circulating-aldosterone-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "glucocortocoid-insensitive-primary-hyperaldosteronism",
        "name": "Glucocortocoid-insensitive primary hyperaldosteronism",
        "genes": 5,
        "url": "https://dantelabs.com/traits/glucocortocoid-insensitive-primary-hyperaldosteronism"
      },
      {
        "slug": "dexamethasone-suppressible-primary-hyperaldosteronism",
        "name": "Dexamethasone-suppressible primary hyperaldosteronism",
        "genes": 3,
        "url": "https://dantelabs.com/traits/dexamethasone-suppressible-primary-hyperaldosteronism"
      }
    ],
    "genes": [
      {
        "slug": "cacna1d",
        "symbol": "CACNA1D",
        "hgnc": "HGNC:1391",
        "name": "calcium voltage-gated channel subunit alpha1 D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1d"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      }
    ]
  }
}