{
  "url": "https://dantelabs.com/traits/postnatal-macrocephaly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "postnatal-macrocephaly",
    "id": "HP:0005490",
    "name": "Postnatal macrocephaly",
    "definition": "The postnatal development of an abnormally large skull (macrocephaly).",
    "synonyms": [
      "Macrocephaly, postnatal"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "url": "https://dantelabs.com/traits/macrocephaly"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "aqp4",
        "symbol": "AQP4",
        "hgnc": "HGNC:637",
        "name": "aquaporin 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aqp4"
      },
      {
        "slug": "fam111a",
        "symbol": "FAM111A",
        "hgnc": "HGNC:24725",
        "name": "FAM111 trypsin like peptidase A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam111a"
      },
      {
        "slug": "gprc5b",
        "symbol": "GPRC5B",
        "hgnc": "HGNC:13308",
        "name": "G protein-coupled receptor class C group 5 member B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gprc5b"
      },
      {
        "slug": "hepacam",
        "symbol": "HEPACAM",
        "hgnc": "HGNC:26361",
        "name": "hepatic and glial cell adhesion molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hepacam"
      },
      {
        "slug": "mlc1",
        "symbol": "MLC1",
        "hgnc": "HGNC:17082",
        "name": "modulator of VRAC current 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlc1"
      },
      {
        "slug": "gnb1",
        "symbol": "GNB1",
        "hgnc": "HGNC:4396",
        "name": "G protein subunit beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb1"
      },
      {
        "slug": "oplah",
        "symbol": "OPLAH",
        "hgnc": "HGNC:8149",
        "name": "5-oxoprolinase, ATP-hydrolysing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oplah"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "pak1",
        "symbol": "PAK1",
        "hgnc": "HGNC:8590",
        "name": "p21 (RAC1) activated kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pak1"
      }
    ]
  }
}