{
  "url": "https://dantelabs.com/traits/pica",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "pica",
    "id": "HP:0011856",
    "name": "Pica",
    "definition": "An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-eating-behavior",
        "name": "Abnormal eating behavior",
        "url": "https://dantelabs.com/traits/abnormal-eating-behavior"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ash1l",
        "symbol": "ASH1L",
        "hgnc": "HGNC:19088",
        "name": "ASH1 like histone lysine methyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ash1l"
      },
      {
        "slug": "chd8",
        "symbol": "CHD8",
        "hgnc": "HGNC:20153",
        "name": "chromodomain helicase DNA binding protein 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd8"
      },
      {
        "slug": "elp2",
        "symbol": "ELP2",
        "hgnc": "HGNC:18248",
        "name": "elongator acetyltransferase complex subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elp2"
      },
      {
        "slug": "taf4",
        "symbol": "TAF4",
        "hgnc": "HGNC:11537",
        "name": "TATA-box binding protein associated factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4"
      },
      {
        "slug": "cdk13",
        "symbol": "CDK13",
        "hgnc": "HGNC:1733",
        "name": "cyclin dependent kinase 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk13"
      },
      {
        "slug": "dhps",
        "symbol": "DHPS",
        "hgnc": "HGNC:2869",
        "name": "deoxyhypusine synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhps"
      },
      {
        "slug": "pgm2l1",
        "symbol": "PGM2L1",
        "hgnc": "HGNC:20898",
        "name": "phosphoglucomutase 2 like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm2l1"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zswim6"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      }
    ]
  }
}