{
  "url": "https://dantelabs.com/traits/palmar-hyperhidrosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "palmar-hyperhidrosis",
    "id": "HP:0006089",
    "name": "Excessive sweating of hands",
    "label": "Palmar hyperhidrosis",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-morphology-of-the-palm",
        "name": "Abnormal skin morphology of the palm",
        "url": "https://dantelabs.com/traits/abnormal-skin-morphology-of-the-palm"
      },
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      }
    ],
    "narrower": [
      {
        "slug": "palmoplantar-hyperhidrosis",
        "name": "Excessive sweating of palms and soles",
        "genes": 14,
        "url": "https://dantelabs.com/traits/palmoplantar-hyperhidrosis"
      }
    ],
    "genes": [
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "adamts15",
        "symbol": "ADAMTS15",
        "hgnc": "HGNC:16305",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 15",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts15"
      },
      {
        "slug": "ccdc91",
        "symbol": "CCDC91",
        "hgnc": "HGNC:24855",
        "name": "coiled-coil domain containing 91",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc91"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      }
    ]
  }
}