{
  "url": "https://dantelabs.com/traits/osteomyelitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "osteomyelitis",
    "id": "HP:0002754",
    "name": "Bone infection",
    "label": "Osteomyelitis",
    "definition": "Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-musculoskeletal-physiology",
        "name": "Abnormal musculoskeletal physiology",
        "url": "https://dantelabs.com/traits/abnormal-musculoskeletal-physiology"
      },
      {
        "slug": "increased-inflammatory-response",
        "name": "Increased inflammatory response",
        "url": "https://dantelabs.com/traits/increased-inflammatory-response"
      }
    ],
    "narrower": [
      {
        "slug": "foot-osteomyelitis",
        "name": "Foot bone infection",
        "genes": 3,
        "url": "https://dantelabs.com/traits/foot-osteomyelitis"
      },
      {
        "slug": "mandibular-osteomyelitis",
        "name": "Lower jaw bone infection",
        "genes": 3,
        "url": "https://dantelabs.com/traits/mandibular-osteomyelitis"
      },
      {
        "slug": "osteomyelitis-leading-to-amputation-due-to-slow-healing-fractures",
        "name": "Osteomyelitis leading to amputation due to slow healing fractures",
        "genes": 2,
        "url": "https://dantelabs.com/traits/osteomyelitis-leading-to-amputation-due-to-slow-healing-fractures"
      },
      {
        "slug": "salmonella-osteomyelitis",
        "name": "Salmonella bone infection",
        "genes": 2,
        "url": "https://dantelabs.com/traits/salmonella-osteomyelitis"
      },
      {
        "slug": "unusual-infectious-osteomyelitis",
        "name": "Unusual infectious osteomyelitis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/unusual-infectious-osteomyelitis"
      }
    ],
    "genes": [
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "hgnc": "HGNC:59",
        "name": "ATP binding cassette subfamily C member 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc8"
      },
      {
        "slug": "copz1",
        "symbol": "COPZ1",
        "hgnc": "HGNC:2243",
        "name": "coat protein complex I subunit zeta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copz1"
      },
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "en1",
        "symbol": "EN1",
        "hgnc": "HGNC:3342",
        "name": "engrailed homeobox 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/en1"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "il1r1",
        "symbol": "IL1R1",
        "hgnc": "HGNC:5993",
        "name": "interleukin 1 receptor type 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il1r1"
      },
      {
        "slug": "il1rn",
        "symbol": "IL1RN",
        "hgnc": "HGNC:6000",
        "name": "interleukin 1 receptor antagonist",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il1rn"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "rel",
        "symbol": "REL",
        "hgnc": "HGNC:9954",
        "name": "REL proto-oncogene, NF-kB subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rel"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "tmem63b",
        "symbol": "TMEM63B",
        "hgnc": "HGNC:17735",
        "name": "transmembrane protein 63B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem63b"
      },
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "lpin2",
        "symbol": "LPIN2",
        "hgnc": "HGNC:14450",
        "name": "lipin 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lpin2"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "slco2a1",
        "symbol": "SLCO2A1",
        "hgnc": "HGNC:10955",
        "name": "solute carrier organic anion transporter family member 2A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco2a1"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "hgnc": "HGNC:14211",
        "name": "B cell linker",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blnk"
      },
      {
        "slug": "cd79a",
        "symbol": "CD79A",
        "hgnc": "HGNC:1698",
        "name": "CD79a molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79a"
      },
      {
        "slug": "cd79b",
        "symbol": "CD79B",
        "hgnc": "HGNC:1699",
        "name": "CD79b molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79b"
      },
      {
        "slug": "cltcl1",
        "symbol": "CLTCL1",
        "hgnc": "HGNC:2093",
        "name": "clathrin heavy chain like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cltcl1"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "ighm",
        "symbol": "IGHM",
        "hgnc": "HGNC:5541",
        "name": "immunoglobulin heavy constant mu",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighm"
      },
      {
        "slug": "igll1",
        "symbol": "IGLL1",
        "hgnc": "HGNC:5870",
        "name": "immunoglobulin lambda like polypeptide 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igll1"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "lrrc8a",
        "symbol": "LRRC8A",
        "hgnc": "HGNC:19027",
        "name": "leucine rich repeat containing 8 VRAC subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc8a"
      },
      {
        "slug": "pigh",
        "symbol": "PIGH",
        "hgnc": "HGNC:8964",
        "name": "phosphatidylinositol glycan anchor biosynthesis class H",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigh"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pik3r1",
        "symbol": "PIK3R1",
        "hgnc": "HGNC:8979",
        "name": "phosphoinositide-3-kinase regulatory subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r1"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "spi1",
        "symbol": "SPI1",
        "hgnc": "HGNC:11241",
        "name": "Spi-1 proto-oncogene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spi1"
      },
      {
        "slug": "sptlc2",
        "symbol": "SPTLC2",
        "hgnc": "HGNC:11278",
        "name": "serine palmitoyltransferase long chain base subunit 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sptlc2"
      },
      {
        "slug": "tcf3",
        "symbol": "TCF3",
        "hgnc": "HGNC:11633",
        "name": "transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf3"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "atl3",
        "symbol": "ATL3",
        "hgnc": "HGNC:24526",
        "name": "atlastin GTPase 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atl3"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "c2orf69",
        "symbol": "C2orf69",
        "hgnc": "HGNC:26799",
        "name": "chromosome 2 open reading frame 69",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c2orf69"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "flvcr1",
        "symbol": "FLVCR1",
        "hgnc": "HGNC:24682",
        "name": "FLVCR choline and heme transporter 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flvcr1"
      },
      {
        "slug": "itgb2",
        "symbol": "ITGB2",
        "hgnc": "HGNC:6155",
        "name": "integrin subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb2"
      },
      {
        "slug": "mcts1",
        "symbol": "MCTS1",
        "hgnc": "HGNC:23357",
        "name": "MCTS1 re-initiation and release factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcts1"
      },
      {
        "slug": "ncf2",
        "symbol": "NCF2",
        "hgnc": "HGNC:7661",
        "name": "neutrophil cytosolic factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf2"
      },
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "hgnc": "HGNC:10600",
        "name": "sodium channel epithelial 1 subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1b"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "hgnc": "HGNC:10602",
        "name": "sodium channel epithelial 1 subunit gamma",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1g"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "syk",
        "symbol": "SYK",
        "hgnc": "HGNC:11491",
        "name": "spleen associated tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syk"
      },
      {
        "slug": "znf341",
        "symbol": "ZNF341",
        "hgnc": "HGNC:15992",
        "name": "zinc finger protein 341",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf341"
      },
      {
        "slug": "dnajc21",
        "symbol": "DNAJC21",
        "hgnc": "HGNC:27030",
        "name": "DnaJ heat shock protein family (Hsp40) member C21",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc21"
      },
      {
        "slug": "efl1",
        "symbol": "EFL1",
        "hgnc": "HGNC:25789",
        "name": "elongation factor like GTPase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efl1"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "pgm3",
        "symbol": "PGM3",
        "hgnc": "HGNC:8907",
        "name": "phosphoglucomutase 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm3"
      },
      {
        "slug": "plekhm1",
        "symbol": "PLEKHM1",
        "hgnc": "HGNC:29017",
        "name": "pleckstrin homology and RUN domain containing M1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhm1"
      },
      {
        "slug": "sbds",
        "symbol": "SBDS",
        "hgnc": "HGNC:19440",
        "name": "SBDS ribosome maturation factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sbds"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "ano5",
        "symbol": "ANO5",
        "hgnc": "HGNC:27337",
        "name": "anoctamin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano5"
      },
      {
        "slug": "cyba",
        "symbol": "CYBA",
        "hgnc": "HGNC:2577",
        "name": "cytochrome b-245 alpha chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyba"
      },
      {
        "slug": "dnmt1",
        "symbol": "DNMT1",
        "hgnc": "HGNC:2976",
        "name": "DNA methyltransferase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt1"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "ncf1",
        "symbol": "NCF1",
        "hgnc": "HGNC:7660",
        "name": "neutrophil cytosolic factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf1"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "retreg1",
        "symbol": "RETREG1",
        "hgnc": "HGNC:25964",
        "name": "reticulophagy regulator 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/retreg1"
      },
      {
        "slug": "tnfsf11",
        "symbol": "TNFSF11",
        "hgnc": "HGNC:11926",
        "name": "TNF superfamily member 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf11"
      }
    ]
  }
}