{
  "url": "https://dantelabs.com/traits/microspherophakia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "microspherophakia",
    "id": "HP:0030961",
    "name": "Microspherophakia",
    "definition": "Microspherophakia is a rare congenital anomaly characterized by the abnormal spherical shape of the crystalline lens. It is characterized by an increased anteroposterior thickness of the lens associated with reduced equatorial diameter. The primary pathology lies in the development of zonules. The condition is often bilateral and is characterized by small, thick, and spherical lenses.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-lens",
        "name": "Absent/small lens",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-lens"
      },
      {
        "slug": "spherophakia",
        "name": "Spherophakia",
        "url": "https://dantelabs.com/traits/spherophakia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "adamts10",
        "symbol": "ADAMTS10",
        "hgnc": "HGNC:13201",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/adamts10"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "ltbp2",
        "symbol": "LTBP2",
        "hgnc": "HGNC:6715",
        "name": "latent transforming growth factor beta binding protein 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ltbp2"
      },
      {
        "slug": "adamts17",
        "symbol": "ADAMTS17",
        "hgnc": "HGNC:17109",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 17",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts17"
      },
      {
        "slug": "rragc",
        "symbol": "RRAGC",
        "hgnc": "HGNC:19902",
        "name": "Ras related GTP binding C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragc"
      },
      {
        "slug": "foxc1",
        "symbol": "FOXC1",
        "hgnc": "HGNC:3800",
        "name": "forkhead box C1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxc1"
      },
      {
        "slug": "pax6",
        "symbol": "PAX6",
        "hgnc": "HGNC:8620",
        "name": "paired box 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax6"
      },
      {
        "slug": "trim44",
        "symbol": "TRIM44",
        "hgnc": "HGNC:19016",
        "name": "TRIM family member 44",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim44"
      }
    ]
  }
}