{
  "url": "https://dantelabs.com/traits/long-segment-aganglionic-megacolon",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "long-segment-aganglionic-megacolon",
    "id": "HP:0011285",
    "name": "Long-segment aganglionic megacolon",
    "definition": "A type of aganglionic megacolon in which the aganglionic segment extends proximal to the sigmoid.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "aganglionic-megacolon",
        "name": "Enlarged colon lacking nerve cells",
        "url": "https://dantelabs.com/traits/aganglionic-megacolon"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gdnf",
        "symbol": "GDNF",
        "hgnc": "HGNC:4232",
        "name": "glial cell derived neurotrophic factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdnf"
      },
      {
        "slug": "sox10",
        "symbol": "SOX10",
        "hgnc": "HGNC:11190",
        "name": "SRY-box transcription factor 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox10"
      }
    ]
  }
}